The new Tosoh AIA 900 analysers have been trialled for the last 18 months at Liphook Equine Hospital, which was the first practice to introduce ACTH testing for horses 25 years ago and gets hundreds of blood samples every week from veterinary practices all over the UK and Europe.
Professor Andy Durham, who heads up the laboratory at Liphook, said the test period has shown that the new machine produces more accurate results primarily because it’s less sensitive to ACTH degrading in blood samples between collection and receipt by the laboratory.
Andy said: “There are several analytic methods available for use in horses, and we wanted to see if this alternative machine had diagnostic benefits over the ones we’d used previously.
"The ACTH molecule we test for immediately begins to break down after a blood sample is taken, even if you handle it carefully and place it in chilled packaging, but this new analyser is able to detect much more of the degraded ACTH molecule, and therefore it gives a more accurate result.
“As a comparison, ACTH values measured using the previous method suffered about three to four times more degradation over 24 hours.
"What this means for horse owners is that it will reduce the risk of false negative results in ACTH tests, so more horses suffering from Cushing’s disease will receive the treatment they need.”
In testing, the new analysers also demonstrated greater accuracy when measuring insulin levels in blood samples.
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