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Pharmacokinetics of cetirizine in healthy cats

Mark Papich and others, North Carolina State University

Cetirizine is the active metabolite of the antihistamine agent hydroxyzine and is preferred for use in treating human skin allergies because it has less of a sedative effect than the parent compound. The authors investigate the pharmacokinetics of cetirizine in healthy cats, using high performance liquid chromatography to measure plasma levels up to 24 hours after a single 5mg dose of cetirizine dihydrochloride.

Concentrations remained above the effective human concentration for at least 24 hours after treatment.

American Journal of Veterinary Research 69 (5): 670-674.

Abstract reproduced by kind permission of Veterinary Practice magazine