Dog, Liver, Cytology: Hepatocellular degeneration (vacuolar hepatopathy)

Cloudy swelling are themselves non-specific changes and can be due to inflammatory–, toxic-, metabolic- and anoxic insults, glycogen accumulation.

Bile acid induced cell damage resulting from cholestasis (classed as hydropic degeneration ) can also occur.

Extra-hepatic diseases like Cushing’s disease or diabetes mellitus, chronic infections, peritonitis, chronic dental disease, pyelonephritis, numerous chemical toxins or therapeutic agents, endocrine diseases are some disorders to consider but the changes may can due to primary hepatic disease.

First published: Tue, Oct 5 2010