The March 2025 Cattle Highlights Report from the Royal GD in the Netherlands has revealed that the proportion of paromomycin-resistant isolates has jumped from 48% in 2021 to 72% in 2024.
The report also highlights an increase in the detection of cryptosporidiosis in calves up to 14 days of age.
MSD says that while it is unclear whether paromomycin is being used to treat E.coli or cryptosporidiosis, the rising use of the antibiotic could be contributing to greater exposure and increased resistance in E.coli K99.
Kat Baxter-Smith MRCVS (pictured), a vet advisor at MSD Animal Health, said: “What we need now is a mindset shift—moving away from routine antibiotic use and towards a more robust, preventative management strategy.
“It’s not about eliminating treatment altogether but using it only when it is really needed.”
“Vaccination, clean pens, and ensuring that every calf receives the right volume and quality of colostrum are the real cornerstones of effective scour control.
“Using vaccines such as Bovilis Rotavec Corona for rotavirus, coronavirus, and E.coli and Bovilis Cryptium for Cryptosporidium parvum is one of the most effective ways to reduce the incidence of neonatal diarrhoea.
"By vaccinating the dam, we ensure the calf has the best possible immunity at birth by ingesting the fortified colostrum and transition milk in the first days of life, which significantly reduces reliance on antibiotics and minimises disease risks.”
The report emphasises best-practice principles such as effective colostrum management, good hygiene and housing, balanced dry cow transition and strategic vaccination of the dam.
The report also recommends halofuginone (Halocur) as the first-line treatment for cryptosporidiosis, due to its targeted action and significantly lower risk of contributing to AMR.
Kat added: "By embracing these proactive strategies, vets and farmers can take a crucial step towards safeguarding calf health, reducing reliance on antibiotics, and combating the growing threat of antimicrobial resistance.”
https://issuu.com/gezondheidsdienstvoordieren/docs/highlights_report_cattle-march_2025
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