Janssen Animal Health has produced a new DVD called 'Fluke: That's a Fact', which is available free from the company.
The 18 minute film features TV presenter Michaela Strachan discussing the big issues surrounding fluke in sheep, such as the effects on productivity and fertility and the need to adapt treatment regimes to reflect the current challenge in the environment, weather patterns and the possibility of resistance to commonly used flukicides. There is also a section on Haemonchus, the Barber's Pole worm, as the parasite has been reported in a number of farms in the last few years.
According to the company, fluke is becoming increasingly common and is moving into new areas of the UK. There is increasing evidence that a single autumn / winter dose of flukicide may not always be enough to control the disease on some farms and more frequent dosing programmes are now often proposed that look more long term to reduce the level of the disease on farms, especially on those farms with high infection pressure. The film clearly explains these different approaches and the benefits of treating at various times of the year.
Janssen's Livestock Marketing Manager Nigel Underwood hopes the film will be a great educational tool that will help both farmers and SQPs better understand the disease: "With ten easy to watch sections, people will be able to listen to the whole story or just dip into those areas where they feel they need to know more. With her long standing interest in the countryside and wildlife, Michaela Strachan was the perfect choice to present what can be a rather complex story and I'm sure everyone will enjoy her clear explanation of the facts."
To request a DVD or for further information, please contact Janssen Animal Health, 50-100 Holmers Farm Way, High Wycombe, Bucks, HP12 4EG. Tel 01494 567555 Fax 01494 567556 Email: ahealth@its.jnj.com www.janssenanimalhealth.com/uk
Janssen Animal Health has launched a new website providing information on the subject of coccidiosis in calves and lambs: www.takingcareofcoccidiosis.com.
The website builds on the findings of an expert workshop on bovine coccidiosis held at the First European Buiatrics Conference, which was facilitated by Janssen. In particular, the site looks at all of the areas that the experts focused on as being especially problematic, including immunity, sources of infection, risk factors, prevention and treatment.
According to the company, arriving at a diagnosis of coccidiosis is not always straightforward: it must be supported by history and clinical signs, as well as evidence of pathogenic species of the Eimeria parasite. Interpretation of oocyte counts can be particularly difficult and results have to be viewed in the context of the farm situation. The site contains explanations about the timing of sampling and how that can impact upon the results.
Janssen adds that treatment has traditionally relied on fluid therapy and the use of sulphonamide drugs but recommendations on the use of more recently introduced treatments such as diclazuril (Vecoxan) focus on single dose treatments administered 14 days after a stress factor - such as moving to a higher risk environment, weaning or transportation. The various treatment strategies including prophylactic and metaphylactic approaches are described for those who have experienced problems with coccidiosis in the past and want to avoid recurrence on an individual farm.
Janssen says the site is an ideal on-line resource for veterinary professionals, SQPs and farmers looking to update their knowledge, seeking a tool that explains the disease in greater depth or just searching for specific information that helps in their own individual situation or with interpretation of a difficult case, www.takingcareofcoccidiosis.com/.
A study by Janssen Animal Health has, according to the company, demonstrated that a leading herbal wormer had no demonstrable efficacy against common poultry worms1.
The trial, done to Good Clinical Practice (GCP) Standards, involved 48 chickens that had become naturally infected with three different poultry worms - Capillaria (Hairworm) species, Heterakis gallinarum (Caecal worm) and Ascaridia galii (Large roundworm). The birds were randomly assigned to one of three groups:
A. Flubenvet treated groupB. Herbal wormer treated groupC. Control (untreated) group.
The herbal treatment was administered for 3 days in-feed, as required by the 'on-pack' instructions and Flubenvet was given for 7 days as required on the product data sheet. Droppings were collected from individual birds and group pens at intervals for 2 weeks and examined for the presence of worm eggs
Table 1: Worm Count Summaries
Group
Minimum
Maximum
Median
A (Flubenvet treatment)
0.00
19.00
B (Herbal treatment)
108.00
1327.00
425.00
C (no treatment)
74.00
958.00
302.00
The results showed that very few worm eggs were present after one 7-day treatment with Flubenvet. In contrast, those that had no treatment or the herbal treatment still had hundreds of worm eggs in their droppings, suggesting that there were still many adult egg-laying worms present inside the chickens.
Janssen says poultry keepers who rely on preparations like this particular natural wormer may well be building up problems, as the additional numbers of worm eggs in the environment add to the infection pressure and can result in greater worm burdens for their birds. Birds with high worm burdens are more likely to become ill.
According to the Veterinary Medicines Regulations 2009 any product making veterinary medicinal claims needs to be licensed by the Veterinary Medicines Directorate. A licensed product has to show proven efficacy and safety for the animal species involved. Licensed veterinary medicines can be identified by their Vm number, which is shown on-pack. Products termed 'nutritional supplements', that are not licensed do not require the manufacturer to produce any proof of efficacy or safety. It is often easy to buy such products 'off the shelf' because they are not subject to any controls. Any poultry keeper who cares about the health and welfare of the birds is advised to think carefully about their choice of wormer and to seek advice from a vet pharmacist or Suitably Qualified Person (SQP).
1 Evaluation of the efficacy of flubendazole in comparison with a herbal wormer in the treatment of naturally acquired infections of Ascaridia galli, Heterakis gallinarum, and intestinal Capillaria spp in Chickens, Janssen Animal Health
Janssen Animal Health has launched Domosedan Gel, an oromucosal gel for the sedation of horses.
Janssen says Domosedan Gel, which contains 7.6 mg/ml (40mcg/kg) detomidine, induces sedation and analgesia with the efficacy and recovery comparable to Domosedan injection. Domosedan Gel is administered under the horse's tongue, so it is rapidly absorbed.
The company also says Domesedan Gel can replace physical restraint and improve safety during treatments, diagnostics and transport, and that the gel is ideal for horses that are nervous or needle-shy and when owners need more control during clipping, shoeing, dental treatments and boxing.
Nicki Glen, marketing manager at Janssen Animal Health said: "Domosedan Gel is proven to be both effective and easy-to-administer with 98% of horses accepting the gel and owners finding it easy and convenient to use.
"The gel starts to be absorbed immediately and demonstrates a reliable sedatory effect and high safety margin, making it an ideal solution for sedation and restraint when performing non invasive procedures on horses."
For further information, please contact your Janssen Animal Health territory manager.
Janssen Animal Health has released the results of a survey which suggests incorrect worming strategies on many pig units in the UK are costing the industry dearly.
Most state they do not worm weaners, growers or finishing pigs at all and, while most sows are wormed, only a third treat newly-arrived gilts and boars in quarantine.
Phil Macdonald, UK and Ireland pig business manager at Janssen said: "Worm infestations can harm growth rate and feed efficiency, they can reduce abattoir returns and increase the cost of medication".
According to the company, the survey responses point to confusion among some producers on what constitutes a strategic worming programme. Most, 68 per cent, state they have implemented strategic programmes, but fewer than two-thirds of these cover all pigs on a unit and even fewer correctly base their programmes on the pre-patent period of worms.
Phil said: "It's important that all pigs on a unit are covered by the programme, otherwise there is a higher potential for reinfection. To be effective, the anthelmintic treatment periods need to be based on the pre-patent period of worms, so that treatment interrupts their life cycle.
"It requires a strategic worming programme with a broad spectrum anthelmintic such as Flubenol and Solubenol 100mg/g, which is the first and only water-soluble benzimidazole in the market. These are effective against larvae and worm eggs of a number of worm species as well as the large roundworm, Ascaris suum. Migrating larvae of the large roundworm cause Milk Spot lesions in pig livers, which are damaging to animal welfare and unit economics."
The make-up of UK units in the survey was 58 per cent breeder/finisher, 39 per cent finisher, 3 per cent weaner/finisher. Most, 68 per cent, use dry pelleted feed, 16 per cent wet feed and 16 per cent have both feed systems.
There is wide variation in worming programmes among producers. Most breeders worm their sows - 17 per cent once a year, 56 per cent twice and 11 per cent three times. With boars, 28 per cent worm them once a year, 44 per cent twice and 11 per cent three times. But only one-third (34 per cent) of breeders worm newly-arrived gilts and boars in quarantine.
72 per cent of producers with breeding sows who responded do not worm weaners and 80 per cent do not worm growers. Of the total responses, including specialist finishers, 68 per cent do not worm finishing pigs.
Most producers, 81 per cent, stated that they are aware that livers with Milk Spot lesions have to be trimmed or totally condemned, adding significant annual costs for disposal.
68 per cent admit to Milk Spot lesion levels of 25 per cent in consignments of pigs. Another 10 per cent experience up to 75 per cent livers with Milk Spot damage, and 3 per cent have had every pig liver in a consignment trimmed or condemned because of lesions. The feedback to producers comes from the BPEX Pig Health Scheme, of which 88 per cent of producers are members.
Only 58 per cent of producers are aware that more traditional worming methods allow pigs continuously to reinfect each other and their environment. Traditional programmes do not take the worm's life cycle into account.
The detrimental effect of worm damage that causes most concern to producers is lost growth/poorer feed conversion (29 per cent). Others considered the most important to be:
Phil says research shows that losses in daily liveweight gain alone add up to £2.31 per slaughter pig where liver condemnations are 30 per cent. "The frightening fact is that the loss is for every slaughter pig, not just those with Milk Spot lesions.
"In a 300-sow herd producing 23 pigs per sow per year that's a loss of £15,939 a year. On a 1,000-sow unit that exceeds a horrendous £53,000 annually, and these figures take no account of other areas of loss mentioned."
An adult female worm can shed hundreds of thousands of eggs each day, which pigs pass out in their dung. Worm eggs can remain infective for up to 10 years. Other pigs ingest them and the reinfection process begins.
Phil said: "A strategic worming programme that treats all pigs on a unit simultaneously is the only effective way to almost completely eliminate the problem. The survey has shown there is considerable potential for a large proportion of producers to improve productivity and cut costs by focusing on this critical area of management."
Janssen Animal Health is advising vets to be on the look out for coccidiosis as the spring lambing season approaches: cases usually rise in March and peak in April and May.
According to the company, some reports also suggest that the incidence of coccidiosis in calves may apparently increase during the grazing months. However, vets are reporting that interpretation of laboratory tests used to confirm diagnosis, such as oocyst count, can be problematic due to the ubiquitous nature of the Eimeria parasite in the UK.
Young animals may be infected by oocysts shed by asymptomatic carriers or infected older cohort animals. Low levels of challenge can help young animals develop immunity but exposure to high oocyst numbers, particularly in combination with stress can lead to clinical and subclinical forms of the disease. Diagnosis can be problematic, particularly in subclinical cases of disease where failure to gain weight is the main presenting sign and in clinical cases the differential diagnoses include all causes of scour in young animals.
Janssen Animal Health has suggested a few indicators that may be useful in identifying cases of coccidiosis. The Vecoxan Coccidiosis Survey in 2008 and 2009 asked farmers about their experiences of coccidiosis and identified that bad weather was a major trigger particularly in lambs; while castration and weaning were also factors in calves. As the parasite life cycle is 21 days, vets should be alert to disease 2-3 weeks after a stressor event.
The company has also suggested a few guidelines to aid interpretation of laboratory results:
Janssen says Vecoxan (diclazuril) does not interfere with the development of immunity and kills all stages of the parasite in the host.
Janssen Animal Health has announced that it has acquired the distribution rights for a range of sedatives and anaesthetics for small and large animals, including Dexdomitor, Domitor and Antisedan.
Janssen aquired the marketing and distribution rights, which were previously held by Pfizer Inc, from Orion Corporation.
Dr. Enno Gottschalk , Janssen's European Director Marketing and Sales said: "This acquisition of distribution rights results in the perfect combination of proven and effective products with the outstanding service and technical selling capabilities of Janssen Animal Health. The products include the sedative Dexdomitor and Domitor, as well as the antagonist Antisedan. Among large animals, predominantly horses, the sedative injection Domosedan is now on offer as part of the Janssen Animal Health portfolio."
Research amongst veterinary surgeons by Janssen Animal Health, maker of Cavalesse oral and Cavalesse topical, has revealed that owners could be doing more harm than good when it comes to managing sweet itch in their horses.
92% of vets questioned are aware that people follow old wives' tales by administering lotions and potions such as garlic and olive oil to ward off flies during the summer sweet itch season, when garlic actually has the opposite effect of attracting them.
According to Janssen, it is thought that only a quarter of horse owners are aware that it is important to carry out preventative measures before the start of the midge season to help alleviate sweet itch. 14% of people are thought to go to their vet for advice on sweet itch, while 30% seek help from their country store or tack shop, 27% search for information on websites and 26% ask other horse owners for guidance. This is despite the fact that 92% of those questioned believe that sweet itch would clear up quicker if people sought advice from their veterinary surgeon.
Nicki Glen, marketing manager at Janssen Animal Health said: "Sweet itch can be an incredibly difficult and frustrating condition to manage, however horse owners do not tend to seek advice from their vets. It is therefore important to educate horse owners while you are on yard visits with pro-active advice on the condition for the long-term health and welfare of horses."
Cavalesse is a natural food supplement containing a specialised formulation of water-soluble vitamins and minerals, including nicotinamide. Once a month the contents of each sachet are dissolved in water to form an oral solution, which can be administered daily via a special pipette, either by sprinkling over a small handful of feed or adding to a treat such as a sugar lump. Janssen says the supplement helps horses maintain a healthy skin and promotes normal immune function in horses prone to summer allergies.
Cavalesse Topical is a skincare gel that can be used in combination with the Cavalesse solution. The gel can be applied to the skin to help support natural immunity from the outside, whilst the oral solution works in partnership from the inside.
For further information on Cavalesse and Cavalesse Topical please contact your Janssen Animal Health account manager or phone 01494 567555.
Maprelin, which contains a new active molecule, Peforelin, is a gonadotropin releasing hormone (GnRH). A single, low volume injection of the ready-to-use solution induces oestrus in sows after weaning, and in sexually mature gilts where oestrus has been synchronised with Regumate Porcine.
According to the company, it works by selectively inducing the release of the animal's own follicle stimulating hormone (FSH), leading to follicle growth - critical to successful reproduction - and the stimulation of oestrus. Conventional GnRHs, because of their mode of action, are used mainly to induce ovulation.
Janssen says Maprelin is the next step in its pig reproduction programme, named Syncoris. Cornerstone of this programme is Regumate for gilt synchronisation.
Trials have shown that with the use of Maprelin (compared with control groups of breeding animals) the number of gilts and sows showing oestrus within six days of treatment increased by about 15 percentage points (Table 1). For first-litter sows the figure was more than 8 percentage points. The duration of oestrus was not affected.
Gilts came on heat two days faster than with Regumate alone, and the weaning to oestrus interval with sows achieved similar statistically significant reductions.
Farrowing rate increased by over 5 per cent for sows, by 6 per cent for first-litter sows and just on 8 per cent for gilts.
Added to those benefits, for each 100 inseminations sows produced an extra 104 piglets, first-litter sows 105 and gilts an even more impressive 158. All gilt groups in the trials, including the control groups, were synchronised with Regumate. With unsynchronised gilts it is not possible to predict the correct time to inject Maprelin.
Phil Macdonald, the company's UK pig and poultry business manager, says the objective of every producer is profitable pigmeat production. "In the UK and other EU states the costs of feed, housing and labour are considerably higher than in other major pig-producing sectors of the world.
"This makes it important for UK producers to optimise management of the reproductive process. Maprelin is a valuable tool that can help with this objective."
The precision injection gun with Maprelin enables accurate delivery of the small amounts required. Gilts require a 2.0 ml dose 48 hours after their last Regumate treatment, first-litter sows a 0.5 ml dose 24 hours after weaning and multi-litter sows 2.0 ml 24 hours after weaning. Injections are intramuscular.
The solution requires no mixing, reducing the possibility for errors. Opened vials have a shelf life of 28 days and unopened vials a shelf life of two years. Sows and gilts need only one injection per parity, and the withdrawal period for meat and offal is zero days.
Janssen Animal Health has highlighted that enforcement of the Veterinary Medicines legislation will require thousands of poultry owners to change the way they worm in the future.
The company says that in the past many poultry keepers with small to medium sized flocks have used Flubenvet® 2.5% Medicated Premixture 240 gram pack. However, going forwards, it will no longer be possible to do so unless individuals (or companies) are approved and registered to mix medicines into feed. The Flubenvet® 1% 60 gram pack for domestic poultry launched in 2008 remains widely available and can still be used without having to register. Each 60 gram pack is suitable to treat around 20 chickens.
Registered retailers are also only able to sell medicated premixtures for mixing into more than 30kg of feed to customers who are specifically registered with the VMD to mix these into animal foods.
Janssen Animal Health vet Nigel Underwood said: "We are advising all poultry keepers of this legislation. We must comply with the law and are simply not able to supply unregistered wholesalers, merchants, pharmacies of vet practices with medicated premixtures unless they are approved.. The new 60 gram domestic poultry pack of Flubenvet® 1% was developed specifically for the smaller poultry owner and is exempt from the legislation. It is available from vets, pharmacists and suitably qualified animal health advisers and poultry owners do not have to be registered to use it."
Janssen Animal Health is encouraging vets and nurses to think 'chicken' this spring.
According to the company, all the evidence suggests that there has been a massive increase in the number of people keeping a few chickens in their garden, resulting in a new breed of chicken owner who often has different expectations regarding healthcare, and views their birds as 'pets'.
Vet Nigel Underwood from Janssen Animal Health said: "It is very tempting for small animal practitioners to think that domestic poultry keepers are the preserve of large animal practices but it is very likely that many cat and dog owners will own chickens too and trust their vet to give them advice about the basic healthcare needs of all their pets."
This spring there is a big opportunity to make poultry owners aware of the need to worm their birds. The return of warmer weather can signal an increase in poultry worm numbers as the ambient temperature increases above 10 degrees centigrade and more worm eggs become infectious. Studies have shown that peak worm counts often coincide with peak chicken egg production. Unless chickens, turkeys and geese are de-wormed there is a risk that egg production could suffer, just when poultry keepers should be enjoying their best yields. Some may even notice smaller eggs and loss of shell and yolk colour. Birds may suffer weight loss, become anaemic or even die.
One study has shown that older birds are more likely to harbour worms and many domestic poultry keepers find themselves with an ageing flock because they allow their birds to live a full natural lifespan. Free range birds are also much more at risk of picking up parasitic worms because of increased exposure to the outdoors, more contact with wild birds and the opportunities to ingest intermediate hosts such as earthworms, beetles and snails.
Janssen Animal Health's Flubenvet® 60 gram pack is an in-feed treatment that, according to the company, is practical even for those with just a few hens in their garden. Flubenvet 60 gram contains enough wormer to treat around 20 chickens, with no egg withdrawal.
While worms are a year-round problem in poultry it is especially important to treat in the spring to tackle the increasing threat of worm infection. Thereafter, poultry owners will also get the best results if they continue to treat regularly in spring, summer and autumn, when new birds are acquired and before putting birds out to pasture. This helps to ensure that contamination of the chickens' environment with worm eggs is kept at a manageable level, reducing the risk of future infections.
Free client leaflets about worms affecting chickens, geese and turkeys are available by calling Janssen Animal Health on 01494 567555.
Janssen Animal Health has launched a range of skincare products - Cavalesse® and Cavalesse® Topical - to help maintain and support a healthy skin in horses prone to summer skin allergies.
According to the company, summer skin allergies, including sweet itch, which is caused by reactions to bites from Culicoides midges, can be serious and frustrating conditions that affect three to five per cent of all horses in the UK. These allergies can be difficult to manage and are often a real challenge for both horse owners and vets alike.
Cavalesse is a natural food supplement containing a specialised formulation of water-soluble vitamins and minerals, including Nicotinamide. Once a month the contents of each sachet are dissolved in water to form an oral solution, which can be administered daily via a special pipette, either by sprinkling over a small handful of feed or adding to a treat such as a sugar lump. The supplement helps horses maintain a healthy skin by reducing histamine release within the skin, moderating the excessive immune response within the skin, reducing anti-inflammatory reactions and suppressing antigen induced transformation.
To complete the Cavalesse skin management range, Cavalesse Topical is a skincare gel that can be used in combination with the Cavalesse solution. The gel can be applied to the skin to help support natural immunity from the outside, whilst the oral solution works in partnership from the inside.
Helen Goldberg, marketing manager at Janssen Animal Health said: "Summer skin allergies, such as sweet itch, are frustrating conditions that can be difficult to treat. To help prevent the disease, horses are often fully blanketed while out at grass, given limited access to pasture or covered with insect repellents, while treatment has included antihistamines and corticosteroids which can have side-effects.
"Only available via veterinary wholesalers, the Cavalesse range of products will enable owners to protect their horses from the inside, whilst maintaining a healthy skin from the outside."
2ml of Cavalesse should be administered to horses and ponies weighing less than 500kg daily, while horses weighing more than 500kg should be given 3ml per day. Cavalesse Topical should be applied to the skin according to requirements.
For further information, please contact your Janssen Animal Health account manager or phone 01494 567555.
Dairy vets will soon be receiving a DVD highlighting the economic losses due to coccidiosis in cattle, from Janssen Animal Health.
According to the company, coccidiosis is a major cause of scouring and poor growth rates in calves yet recent findings have demonstrated that a massive 61 per cent of the economic loss occurs in sub-clinically infected calves that are not showing any obvious clinical signs. Treated calves have been shown to put on 20 per cent more weight than untreated calves1. Coccidiosis infects between 16 and 27 per cent of adult cattle who act as reservoirs of the disease2,3,4,5. This means that most calves are likely to become exposed to the infectious form of the parasite. After the age of 6 months the majority of calves acquire immunity but if they are exposed to a massive challenge before that time due to large numbers of the coccidial oocysts or due to a stress factor, sub-clinical or clinical disease occurs.
The DVD describes the challenges involved in diagnosing coccidiosis and how to interpret faecal oocyst counts, as well as some of the characteristics of sub-clinical infection in calves. The benefits of metaphylactic and preventative approaches to treatment with Vecoxan®, the only anticoccidial drench licensed for beef and dairy cattle at any age, indoors and out, are discussed.
Nigel Underwood from Janssen Animal Health said: "The diagnosis of non-specific scour is problematic at best but it is important that vets have coccidiosis at front of mind when considering the differential diagnosis. Prompt treatment of the whole batch of calves can stop the disease in its tracks and does not interfere with the development of future immunity. We hope this DVD will provide an update on the latest thinking and help increase recognition of this disease."
The DVD will be sent out in February and any vet with an interest in the disease who does not received one before the end of the month should call Janssen on 01494 567555 to request a copy.
Further information is available from Janssen Animal Health, 50-100 Holmers Farm Way, High Wycombe, Bucks, HP12 4EG Tel 01494 567555 Fax 01494 567556 Email: ahealth@jacgb.jnj.com
References
Janssen Animal Health has made what I am told is a 'very large' donation of Ripercol, a pour-on 20% levamisole w/v broad spectrum anthelminitic for cattle, effective against gastro intestinal nematodes and lungworm, to the Worldwide Veterinary Service (WVS) – a UK registered charity (No.1100485) committed to improving the treatment and welfare of all animal species throughout the world.Nigel Underwood, Livestock Marketing Manager at Janssen said: 'We are very pleased to be able to help improve the health of animals in the developing countries and in turn to help those people who need it most. I’d encourage other pharmaceutical companies and practices to support WVS whenever they can, as they do a fantastic job.'Annie Cook, WVS Director of Veterinary Operations said: 'So far this year we have been able to help over 64 associated charities with nearly £73,000 worth of donated items. This incredibly generous donation of Ripercol from Janssen Animal Health will allow us to provide production animal welfare charities in India, East Africa and South America with a much needed resource'.WVS is currently arranging a Disaster Emergency Response team of veterinary professionals to visit the Internally Displaced People Camps in Kenya created following the election violence. Luke Gamble, WVS Chief Executive Officer, who will be coordinating the team said: 'The high concentration of animals in these camps combined with poor sanitation will promote the spread of disease between animals and is also a public health concern. Simply deworming these animals will improve their productivity and survival, which is vitally important as they are an essential resource to the people in the camps.'