The Animal Health Trust is appealing to veterinary surgeons and nurses to encourage clients who keep their horses on premises that have been affected by Equine Grass Sickness to sign up to the second year of its nationwide EGS vaccine trial.
Equine Grass Sickness (EGS) occurs predominantly in Europe, with Britain experiencing the highest incidence worldwide. In 2014, 59 cases of EGS were reported through the EGS Surveillance Scheme, but it is likely that this represents only a fraction of cases occurring annually throughout Britain.
Almost all cases of EGS occur in horses with access to grazing. The AHT says there is growing scientific evidence to suggest that the disease may be caused by the bacterium Clostridium botulinum type C, commonly found within soil and capable of producing neurotoxins to which horses are particularly sensitive. EGS occurs when a combination of risk factors trigger the production of these toxins within the horse's intestinal tract, causing damage to the nervous system and paralysis of the gut.
As similar equine diseases such as tetanus and botulism can be prevented by vaccination, it is theoretically possible that a vaccine could prevent EGS. To this end the AHT, in collaboration with the Universities of Edinburgh, Liverpool and Surrey launched the EGS field vaccine trial in 2014 in order to establish whether a vaccine could indeed be effective in reducing the risk of the disease. The trial is funded by a number of sources including Neogen Corporation; Animal Welfare Foundation; Horserace Betting Levy Board; Racing Foundation; Moredun Foundation Equine Grass Sickness Fund; Hong Kong Jockey Club; The British Horse Society and the EB Moller Charitable Trust.
Now entering its second year, the EGS vaccine trial involves enrolled horses and ponies receiving either a course of the C. botulinum type C toxoid vaccine or an inactive placebo, as well as an annual booster. The incidence of EGS is monitored throughout the trial to determine the efficacy of the vaccine, and enrolled horses and ponies are closely monitored through regular follow-ups for the duration of the trial.
With 60% of EGS cases occurring during April - June, the highest risk season for EGS is fast approaching. The AHT is appealing to owners who keep their horses on premises that have had at least one case of EGS in the past three years to enrol their horse in the vaccine trial and provide an invaluable contribution to this pioneering research prior to these high risk months. Veterinary practices with clients who fit this description are asked to help the recruitment process by encouraging suitable cases to sign up to the trial.
Dr Jo Ireland, the AHT's Equine Grass Sickness Research Co-ordinator, said: "We have been delighted with the overwhelmingly positive response to the EGS vaccine trial and many owners have welcomed the chance to be a part of such important research. We don't want any eligible horse owners to miss out on the opportunity to contribute towards a potential breakthrough in the prevention of EGS, so we are encouraging more owners to enrol their horses on the trial this year."
To find out more about the vaccine trial or how clients can enrol horses and ponies, visit the AHT's dedicated EGS website www.equinegrasssickness.co.uk or email equinegrasssickness@aht.org.uk.
The study "Influence of dietary restriction and low-intensity exercise on weight loss and insulin sensitivity in obese equids" was carried out by Nick Bamford and colleagues at the University of Melbourne’s Faculty of Veterinary and Agricultural Science, in collaboration with Spillers.
A total of 24 obese horses and ponies were randomly divided into two groups; 'restricted diet only' or 'restricted diet plus exercise'. All horses and ponies were fed the same diet of restricted hay (no grazing), a small amount of alfalfa chaff and soya bean meal, and a vitamin and mineral supplement.
The exercise programme, which was designed following feedback from horse owners to help ensure it could be implemented relatively easily in the real world, consisted of 15 minutes of brisk trotting (with a five minute walk before and after) five days per week for 12 weeks.
The 'restricted diet only' group showed an overall reduction in body weight and body condition score. They had increased levels of adiponectin – a hormone produced by fat cells, low levels of which are a risk factor for laminitis. They had decreased baseline insulin, high levels of which have been linked to an increased risk of laminitis, and decreased leptin, high levels of which are associated with obesity.
Although exercise did not increase weight loss, it did produce additional benefits that were not seen in the 'restricted diet only' group, the most important one being improved insulin sensitivity. More insulin sensitive horses and ponies need to produce less insulin in order to control their blood sugar. This is important because high levels of insulin in the blood and/or reduced insulin sensitivity are risk factors for laminitis. Horses and ponies in the exercise group also had decreased levels of ‘serum amyloid A’, a protein that is a marker for inflammation.
Clare Barfoot RNutr, the research and development manager at Spillers said: "Reducing calorie intake and feeding a diet low in starch and sugar should be the priority for overweight horses and ponies. However, the results of this study suggest that exercise may offer additional health benefits for obese horses and ponies and/or those with ‘EMS’ that cannot be achieved by cutting calories and weight loss alone."
Reference
Photo: Spillers/Steve Bardens
Ceva Animal Health has renamed Tildren, its tiludronate-based bisphosphonate infusion for the treatment of bone spavin in horses, as Equidronate.
Tiludronate has been used to treat bone spavin and navicular disease in Europe for many years and was licensed for bone spavin in the UK in 2008. Ceva says trials published last year show that horses suffering lameness caused by bone spavin can show marked improvement following treatment with an Equidronate infusion, in combination with controlled exercise.
Bone spavin is a chronic aseptic osteoarthritis of the distal tarsal joints and is considered to be one of the most common forms of hindlimb lameness in the horse. Horses with bone spavin experience abnormal bone remodeling changes. According to the company, Equidronate helps to modulate the osteoclasts to help prevent excessive bone removal and give the osteoblasts a chance to catch up. This in combination with adjusting levels of exercise helps to harmonise the bone adaptation needed for the horse to perform its athletic duties.
In the trials one in four horses showed marked improvement; two in four showed improvement, which, when combined with other treatment, enabled the horse to resume former levels of activity and one in four horses showed no response.
Ceva Animal Health has produced a range of explanatory leaflets for horse owners on bone spavin, navicular disease and sacroiliac disease, as well as a helpful booklet detailing the discharge procedures for horses that have been treated with Equidronate.
For free copies and for further product information contact your Ceva sales representative, ring Ceva on 01494 781510 or visit the website at http://www.ceva.uk.com/
Three bursaries are available - two in ruminant and one in companion animal research, each worth up to £4,000.
Annabelle Mohring, Veterinary Advisor at MSD Animal Health said: "We appreciate that the last 18 months have been challenging for many veterinary surgeons and adding new research to this may not be considered a priority. But with the pace of change rapidly increasing, improving business skills and scientific knowledge will become more important than ever for the profession.
"Research forms the foundation of the industry and being awarded a bursary has proved to be a career-changing experience for some participants. We're now welcoming applications as part of our investment in the veterinary community."
Each project should be completed within one to two years and the veterinary surgeon proposals will be judged by objective third party university academics to ensure independent assessment.
The deadline for the MSD Animal Health Veterinary Surgeon Research Bursaries is 30th November 2021.
For further information, visit: www.msdahresearchbursary.co.uk.
Photo: Hattie Barnes who was awarded the 2020 Veterinary Surgeon Bursary in the companion animal sector. She was awarded £4,000 for her analytical, cadaver-based study to investigate different draping protocols in elective orthopaedic surgery. Hattie is currently undertaking a 3-year residency in Equine Surgery at the University of Liverpool.
The British Equine Veterinary Association (BEVA) is urging veterinary surgeons to be on the lookout for outbreaks of Atypical Myopathy (AM) this spring.
Atypical Myopathy is a serious muscle disease found in the UK and Northern Europe. It is linked to horses eating the seeds from trees in the Acer family, including sycamore and box elder. There were more than five times as many cases of AM last autumn than in the previous year and experts have warned that the disease tends to occur more frequently in the spring following an autumn surge, possibly because of the growth of seedlings. The prognosis is poor, with survival rates of less than 25%. Early diagnosis is essential to give the best chance of survival.
Horses that develop AM are usually kept on sparse pastures, near trees from Acer pleudoplatanus (sycamore) or Acer negundo (box elder, pictured right) that shed seeds containing the toxin hypoglycin A. They are often not fed any supplementary hay or feed and may be driven to browse on an accumulation of dead leaves, dead wood and trees in or around the pasture but sometimes well-fed animals are affected. While the tree seeds may not be directly palatable, horses on poor quality grazing may ingest considerable numbers of them.
The clinical signs of AM may include muscle weakness or stiffness, colic-like symptoms, laboured breathing, dark red-brown urine, recumbency or even sudden death. Often the disease will present as an outbreak. Confirmation of diagnosis is by a blood or urine test. The toxin directly targets aerobic energy metabolism so therapy should be targeted at promoting glucose metabolism and provided fluid dieresis.
Preventative advice for horse owners includes:
Professor Celia Marr, Partner at Rossdales, Newmarket, European Specialist in Equine Internal Medicine and Editor of Equine Veterinary Journal said: "New, collaborative research, instigated last year between the University of Liege, the Irish Equine Centre and the Animal Health Trust should shed more light on the characteristics of the disease in this country. Once we know more about the specific causes we should be able to make more positive progress with prevention strategies."
BEVA has provided free online access to two articles from the journal of Equine Veterinary Education on the disease for all vets to help them address the threat.
Volume 25, Issue 5, pages 264-270, May 2013
Management of cases suffering from atypical myopathy: Interpretations of descriptive, epidemiological and pathophysiological findings. Part 1: First aid, cardiovascular, nutritional and digestive care (pages 264-270) G. van Galen and D -M Votion.
Volume 25, Issue 6, pages 308-314, June 2013
Management of cases suffering from atypical myopathy: Interpretations of descriptive, epidemiological and pathophysiological findings. Part 2: Muscular, urinary, respiratory and hepatic care, and inflammatory/infectious status (pages 308-314) G van Galen and D - M Votion.
Biomérieux says the new test, which is used on the Biofire Spotfire System, detects seven infectious respiratory pathogens (six viruses and/or a strain of bacteria*), from a nasopharyngeal swab, in under 20 minutes.
The company says the new test’s ability to distinguish between viral and bacterial infections is important for ensuring antibiotics are used appropriately to reduce the risk of resistance.
Biomérieux says VetFire can be used to make informed decisions about when to isolate and treat animals when respiratory infections are suspected, to mitigate the impact of an outbreak in a contained area, such as a yard, by allowing rapid quarantine measures, and perhaps in time as a standard test ahead of animals travelling for competition, to ensure they are fit and healthy.
VetFire is commercially available in United Kingdom, Ireland and France, with possible expansion plans to other countries in the near future.
https://www.biomerieux.com/corp/en/our-offer/clinical-products/vetfire.html
*Equine Herpesvirus type 1, Equine Herpesvirus type 4, Influenza A, Equine Rhinovirus A, Equine Rhinovirus B, Equine Adenovirus 1, Streptococcus equi equi
The event, which was cancelled last year because of the Covid-19 pandemic, is the first opportunity for the profession to get back together after the past two turbulent years. To mark BEVA’s 60th Birthday, special celebrations are in the pipeline as well as the 13th International Equine Colic Symposium taking place during the event.
BEVA President Lucy Grieve said: "We are all so excited that BEVA Congress is back this year, albeit that it will be a little bit different. You can expect the same event we all know and love but with a few new measures in place to ensure we can all stay safe during these uncertain times. We are also offering a virtual option for those that can’t attend in person, so that no one misses out.”
Congress Committee co-chair Tim Barnett said: “My co-chair Ceri Sherlock and I have been working hard over the past few months to put together a programme that rivals anything we’ve had before. You can expect lectures, discussion and debates on a number of topics including learning from mistakes, working in teams, and a dedicated stream of nursing lectures.”
This year Lucy has selected teamwork as the theme for BEVA Congress 2021, in celebration of the Association’s 60th anniversary. She said: “In modern day veterinary medicine, no one person can satisfactorily deliver all that is required.
“Without a team approach, from vets, nurses, practice managers, farriers and paraprofessionals the potential to maximise the health and welfare of horses cannot be fulfilled.
"This year, we intend to celebrate 60 years of teamwork and how we can do far more to serve our patients as a harmonious team than if we work alone.”
Early bird tickets for BEVA Congress are available from 19th April until 16th August 2021. Tickets provide access to all three lecture halls and exhibition halls as well as the virtual congress hub. They also include a complimentary ticket to the 13th International Equine Colic Symposium.
Early bird BEVA member prices are £499 for vets and £187 for vet nurses for all 3 days (with concessions available for those in their first three years of graduation or on a lower salary). Virtual tickets are £99 for BEVA members.
BEVA has introduced a 'peace of mind' bookings policy to reassure those whose personal situation may change between booking their ticket and the event.
Full details of the BEVA Congress programme will be announced shortly. To find out more and to book your tickets visit http://www.bevacongress.org/
A research project funded by equine charity The Horse Trust has found that lameness is the most common reason for euthanasing a geriatric horse.
According to the charity, this research is the first in the UK to provide data on the causes of death in geriatric horses. Although post-mortem studies have provided some data regarding causes of death, "old age" was previously reported as a common reason for the euthanasia of adult horses.
The research was carried out by Joanne Ireland at the University of Liverpool and led by Dr Gina Pinchbeck. Ireland surveyed horse owners living in the North-West and Midlands areas of England and North Wales who have a horse aged 15 years or older. 918 owners of geriatric horses were followed in a cohort study and 118 mortalities were reported during the 18 month follow-up period, of which 111 were euthanased.
The researchers found that 24% of horses were euthanased due to lameness; an additional 12% were euthanased due to laminitis - a common cause of lameness. After lameness, colic was the next most common cause of euthanasia, with 21% of owners citing this as the main reason.
In an earlier stage of the project, the researchers had found that half the geriatric horses surveyed suffered from lameness, but only 24% of owners reported the problem.
Dr Pinchbeck said: "Although lameness is common in older horses, this is the first study to quantify its contribution to their mortality.
"Owners are often missing the early signs of lameness in their horse, which means the condition isn't being managed and may deteriorate faster."
Dr Pinchbeck said it would be useful to carry out further research into lameness in geriatric horses to find out the main causes of lameness and how these may be prevented or treated.
The research team also found that half of the horses euthanased were suffering from concurrent health problems and these influenced the owner's decision to euthanase in 43% of cases. The most frequently reported additional health problems were musculoskeletal problems, such as arthritis.
The mortality rate among the horses surveyed was 11 per 100 horse-years at risk, meaning that if 100 geriatric horses were followed for a year, an average of 11 would die. The mortality rate for horses over 30 years of age was over five times the rate than in horses aged 15 - 19 years.
Jeanette Allen, Chief Executive of The Horse Trust, said the data provided by this research is likely to provide useful information for both horse owners and vets to enable them to improve the welfare of older horses. She said: "As there are a significant number of geriatric horses in the UK, it is vital that we understand more about the health problems that affect them. We hope that more owners of older horses will give their horse an annual health-check to enable the horse to have a longer, healthier life."
The research was published in the September 2011 issue of Preventive Veterinary Medicine.
Bimeda has announced the launch of Butagran Equi (phenylbutazone), to join its range of analgesics and anti-inflammatories.
Bimeda says that Butagran Equi provides rapid onset of activity with the added convenience for horse owners or professionals of being presented as an easy-to-administer sweetened powder.
Indications include musculo-skeletal conditions that require relief from pain and a reduction in the associated inflammation, including lameness associated with osteoarthritic conditions, bursitis, laminitis and soft tissue inflammation.
Head of Bimeda technical services Padraig Hyland MVB said: "Butagran Equi is particularly suited where continued mobility is considered desirable. It is also of value in limiting post-surgical inflammation, myositis and other soft tissue inflammation and can be used as an anti-pyretic where this is considered advisable, such as in viral respiratory infections. And being a sweetened powder it's quite straightforward for horse owners to administer and dose as prescribed."
He added: "Butagran Equi follows the launch of a number of new products and is proof our desire to provide a comprehensive and relevant equine portfolio backed up with first class technical support."
Intervet/Schering-Plough has launched Vectin chewable tablets, an ivermectin wormer for horses which is administered as a treat straight from the hand rather than in the traditional paste or granule formulation.
According to the company, syringe handling, horse acceptance and the tendency to spit out some or all of the paste are common problems reported by owners when worming their horses, and more than 55% admit that these issues can result in a mixture of emotions, including frustration, anxiety and upset.
Field studies with Vectin showed more than 70% spontaneous acceptance by horses and the simple calculation of one tablet for every 110kg of a horse or foal's bodyweight helps to reduce wastage as unused tablets can be stored away for future use.
Pharmacokinetics studies have demonstrated improved bioavailability (AUC) and maximal concentration (Cmax) when compared with an equivalent competitor ivermectin paste formulation. Trials have also shown that a more consistent blood concentration of ivermectin when given as a chew which could potentially limit the chance of inducing resistance.
Intervet/Schering Plough says that used as part of a strategic worming plan, Vectin chewable tablets control potentially a wide range of endoparasites including small and large strongyles, stomach worms, cutaneous worms and stomach bots.
Vectin chewable tablets are available as a seven-tablet blister pack, perfect for treating a horse or a couple of ponies. For yards, a tub of 60 tablets is available, containing enough to dispense product for worming approximately 12 horses.
Vectin chewable tablets are recommended for use alongside Pyratape P and Panacur in Intervet/Schering-Plough Animal Health's Active3 worming plan, a strategic three-year approach to rotating wormers in order to minimize the risk of resistance developing. Visit http://www.intervet.co.uk/ for a copy of the three-year plan.
Elanco Animal Health has highlighted the results of a new study1 which concludes that Duvaxyn IE-T Plus stimulates a highter protective antibody response than four other equine influenza vaccines commercially available in Ireland.
The trial compared the antibody responses of unvaccinated Thoroughbred weanlings following primary vaccination with Duvaxyn IE-T Plus, Equilis Resequin, Equip FT, Equilis Prequenza Te and ProteqFlu Te.
In addition, following the first vaccination, 43% of the weanlings failed to seroconvert. However, amongst those vaccinated with Duvaxyn IE-T Plus a 100% response rate was observed. The failure rate amongst vaccines other than Duvaxyn IE-T Plus ranged between 7.7% and 78.6%. By the time of the third vaccination (31 weeks after the first) all horses had responded to vaccination.
The study, conducted by the Irish Equine Centre in Johnstone, the Department of Life Sciences at the University of Limerick and the Department of Statistics at Trinity College in Dublin, involved 66 unvaccinated Thoroughbred weanlings on four different stud farms. Following primary vaccination (V1, V2 and V3) with the five vaccines antibody responses were monitored for six months post V3 by single radial haemolysis. Elanco says that the correlation between SRH antibody levels and protection has been well-established and accepted2.
Elanco also highlights a recent study3 which it says demonstrated the ability of Duvaxyn IE-T Plus equine influenza vaccine to cross protect against A/equi-2/Richmond/1/07 (H3N8) two weeks after a two dose primary course. The company says that this is believed to be the first demonstration of cross protection by a current UK equine influenza vaccine against a Florida sub-lineage clade 2 reference strain.
Anna Jackson, national veterinary manager for Elanco Companion Animal Health said: "Most studies carried out by vaccine companies take place under controlled conditions that are optimal for effective vaccination. This latest study shows how well Duvaxyn IET plus stimulates immunity under field conditions against both vaccinal and non-vaccinal strains. Importantly, all the weanlings vaccinated with Duvaxyn seroconverted after the first vaccination, conferring earliest and most reliable protection for these vulnerable animals."
For further information please contact your local Elanco Companion Animal Health key account manager or phone 01256 779881.
References:
Defra Minister David Heath has announced the latest bute (phenylbutazone) test results. The presence of bute has been confirmed in 8 samples out of 206 tests.
Chief Medical Officer Professor Dame Sally Davies has stated that horsemeat containing phenylbutazone presents a very low risk to human health.
Responding to these latest developments the British Veterinary Association (BVA) and British Equine Veterinary Association (BEVA) have issued the following statement:
"The presence of phenylbutazone (or bute) in horses intended for the food chain will be of concern to consumers who rightly expect the UK food chain to be robust. We are grateful to the Chief Medical Officer for clarifying the very low level of risk that this presents to human health and we will work with the FSA and Defra in any way we can to assist their investigations into these incidents.
"The ability to treat horses with bute is very important for equine welfare. Bute provides affordable, long-term pain relief for horses and is unique in this respect.
"The UK Horse Passport Regulations are designed to facilitate the ongoing medical treatment of horses not intended for the human food chain, whilst ensuring that these animals do not enter the food chain.
"We fully support the concept of the Horse Passport Regulations but have argued for some time that there are problems with the system in terms of the number of Passport Issuing Authorities and the vulnerability of the system to fraud. We are very keen to continue our dialogue with Defra and others to find ways to make the system more robust.
"Our members are aware of the strict rules regarding the regulation of medicines (including bute) and the use of horse passports, and in recent years we have provided clear guidance on the regulations to help both vets and their clients. These incidents will hopefully reinforce these messages amongst horse owners and all of us involved in equine healthcare."
Guidance notes are available via the BEVA website Medicines Page (http://www.beva.org.uk/useful-info/Vets/Guidance/Medicines)
Equine charity The Horse Trust has reported an unprecendented number of enquiries from people wanting to rehome their horses and ponies.
In the three weeks since the financial crisis resulted in repossessions, job losses and cash shortages, more than 500 people made inquiries about having their horses rescued or rehomed.
Susan Lewis, The Horse Trust's marketing manager said: "There is a new generation of horses which is being affected in this way. Animals which have been cherished for 20 years and are now approaching retirement age are becoming too expensive for owners to maintain at livery - especially as the winter season is approaching with its inherent requirements for additional feed, housing and veterinary care."
She added: "Most people are saying: 'Help, what can I do? I adore my horse which has lived with me since I was a tiny child - but now I can barely feed myself let alone my horse. He has always come first - but having lost my home and the field in which I keep him, I just don't know where to turn'.
"It isn't a new story - and we have for many years warned horse owners that they face the issues of cost, care and commitment well into the old age of a horse, which can be up to 30 years. Now, however, it seems that we are facing a more widespread crisis."
Like most other horse charities, the Trust's Home of Rest for horses is full to capacity.
"We simply can't take on any other animals," said Susan. "The charity pound is now stretched to breaking point as people's purses dry up - and with rising feed prices and veterinary charges, it now costs more than £17 a day to keep a horse here.
Fort Dodge Animal Health has announced it is working with the authorities to put measures in place to make its West Nile Virus vaccine, licensed in the United States, available to the European equine market. These measures will ensure a vaccine is readily available in the event of an outbreak in the UK.
This news comes as the Zooprophylactic Institute of Teramo, the Italian National Reference Centre for Exotic Diseases, has confirmed an outbreak of WNV among horses in stables in the northern province of Ferrara. About 20 horses are believed to have been affected.
Fort Dodge was the first company to develop and fully license a vaccine to protect horses against this potentially deadly disease. An inactivated whole virus vaccine, it was the only vaccine available in the United States at the height of the 2002 outbreak, which affected 15,000 horses. The U.S. Department of Agriculture credited the vaccine with contributing to the 70 per cent decline in U.S. equine West Nile cases since the height of the outbreak. WNV is now considered endemic in all areas of North America.
"As this latest outbreak of WNV in Italy highlights, the disease presents an increasing threat to the equestrian sector in Europe," says Helen Barnes, EMEA Equine Business Manager for Fort Dodge. "With little current natural immunity among the equine population, the consequences of a major outbreak could be devastating."
"Until now, horse owners in Europe have perhaps believed WNV is not a disease they should be concerned with but the outbreak in Ferrara came out of the blue, and at a time when a human case of WNV was also reported in the same province. This situation of both human and equine cases being reported is identical to that seen in the outbreaks in the United States. It's a stark reminder of the challenge this disease poses, particularly as environmental factors, such as global warming and heavy rains threaten to create mass breeding grounds for mosquitoes," says Barnes.
"Our experience with WNV in the United States has given us an exceptional understanding of the disease and the importance of vaccination. We now look forward to working in partnership with the European governments, the EU Commission and the veterinary community across Europe to help build understanding and knowledge of this dangerous emerging disease threat."
Chanelle has announced the launch of Ketamidor 100 mg/ml Solution for Injection (ketamine), licensed for use in cats, dogs, horses, cattle and swine in the UK and Ireland.
The company says the new product provides a versatile addition to anaesthetic regimes. It can be used in combination with other widely-used anaesthetics and sedatives. Chanelle says it also has analgesic properties that make it particularly beneficial to include in anaesthetic protocols when carrying out painful surgical procedures.
Ketamidor 100mg/ml Solution for Injection has a zero day withdrawal period for milk and meat when used in cattle and pigs, allowing high welfare standards to be maintained without compromising economic returns.
According to Chanelle, ketamine is now experiencing a resurgence of interest as its analgesic properties and minimal impact on spontaneous respiration become increasingly appreciated.1
Angela Wilkin, Chanelle UK's Sales and Marketing Manager said: "Ketamidor makes a great addition to our portfolio of pain management products. Our territory managers are looking forward to speaking to those vets who are already accustomed to using ketamine and those that may be considering adding it to their current protocols."
Current World Organisation for Animal Health (OIE) recommendations are to include a representative strain from each of the two sublineages of equine influenza virus (EIV) - Florida Clade 1 and Florida Clade 2, to deliver optimum protection.
MSD's study was designed to evaluate the efficacy of Equilis Prequenza, containing whole virus Newmarket/2/93 (European strain) and South Africa/4/03 (Clade1) EIV strains, and an HA canarypox vectored vaccine containing Florida Clade 1 and Clade 2 strains.
Two groups of seven Fjord ponies were vaccinated twice, 4 weeks apart (V1 on day 0 and V2 on day 28). One group was vaccinated with Equilis Prequenza (MSD AH) and one group with ProteqFlu (Boehringer Ingleheim). The protective antibody response was measured and ponies were challenged, along with six unvaccinated control ponies, by experimental infection with Wexford/14 (a heterologous clade 2 strain), 1 20 days (4.5 months) after V2, and clinical signs and virus shedding monitored. EI serology was measured by single radial haemolysis (SRH) and hemagglutination inhibition (HI). Clinical signs and virus shedding (measured by qRT-PCR and egg titration) were compared between groups and with controls.
Vicki Farr, BVetMed MRCVS, equine veterinary advisor at MSD Animal Health said: "Following challenge at 120 days after V2 with Wexford/14, this study demonstrates that both vaccines provide a highly significant degree of protection against clinical signs of EI and viral shedding compared to unvaccinated controls. Although the study was not designed to compare the efficacy of the two vaccines, because of practical limitations on the number of animals and hence low power, there was no evidence of any significant differences between these two groups. There was, however, a trend towards slightly lower clinical score on days 4-8 and reduced virus excretion on days 2-5 in the Equilis Prequenza group compared to the HA canarypox vectored vaccine.”
MSD says Equilis Prequenza offers a broad based approach to immunogenicity by addressing and adapting key areas of an equine influenza vaccine - Matrix-C adjuvant, whole virus antigen and strain; efficacy has been proven through challenge trials and longer term protection confirmed by serology.
Vicki added: "Equilis Prequenza addresses key factors involved in promoting effective immunogenicity. It combines the demonstrated efficacy against challenge, with a current circulating strain with an established safety profile. Equilis Prequenza stimulates active immunity against EI providing the reassurance your clients demand. MSD Animal Health is committed to working with equine practices to improve vaccination rates in at-risk horses."
For more information about the trial results contact your MSD Animal Health account manager.
VetCell Bioscience has become the first UK-based stem cell centre to be authorised under the Veterinary Medicines Regulations.
Following a rigorous series of inspections and reports by Good Manufacturing Practice (GMP) Inspectors VetCell, in conjunction with their UK laboratory partner Biobest, were officially authorised as an equine stem cell centre on 1 October 2009.
David Mountford, Chief Operating Officer of VetCell Bioscience said: "To have received formal authorisation so swiftly reflects the high standard of our operation and our ability to lead the field in the increasingly competitive sector of stem cell technology."
Stem cell therapy involves implanting millions of the animal's own stem cells and autologous growth factors directly into the injured tendon or ligament. The service VetCell Bioscience offers is the collection, storage, processing and supply of stem cells suitable for administration back into the donor animal.
According to the company, there is considerable interest from the human sector and studies in human medicine, for the treatment of Achilles tendinopathies, could begin as early as next year.
The charity will be carrying out a study about the disease in collaboration with the Universities of Liverpool and Nottingham. However, because funding for research is limited, and because researchers want it to answer questions around PPID that owners and veterinary surgeons actually want to know, they are asking for your suggestions.
The AHT says that it wants to provide owners and vets with practical and applicable advice that will improve the wellbeing of their horses, based on scientific evidence. So whether that’s a question around how the disease is diagnosed, the best way to treat it or what the long term prognosis is, now is your chance to have your say.
If you own or care for a horse/pony with PPID or are a veterinary surgeon that treats them (or you have done in the past) please visit: www.aht.org.uk/PPID, to take part.
If you have any questions, contact the Project Investigator Becky Tatum by email: becky.tatum @aht.org.uk or by telephone: 01638 751000 Ext. 1241
According to the company, information on best worming strategies for foals and yearlings remains largely anecdotal, making it difficult to develop a clear plan for this age group. Zoetis veterinary surgeon Wendy Talbot has therefore reviewed the recent literature to develop an eight-point plan.
Explaining the guidance, Wendy writes:
Foals and yearlings are usually more susceptible to worms than are adult horses because they have had little chance to develop any immunity. They are more vulnerable to related diseases and tend to have higher egg shedding, which increases the risk of infection. The main parasitic culprits in the UK for foals less than six months of age are large roundworms (ascarids). In older foals and weanlings, small and large strongyles, tapeworms (and pinworms) are the main considerations.1 Yearlings may also have a second wave of large roundworm infection at 8-10 months of age.2 Any control strategy will need to take into account the individual circumstances such as stocking density, pasture management and previous disease history.
Guidelines for parasite control in foals suggest a first treatment with fenbendazole at 2-3 months of age, targeting large roundworm, followed by another treatment at 5-6 months. Alternatively, pyrantel may be considered for these doses; however, there may be resistance in some areas and foals with large adult ascarid burdens may be at higher risk of intestinal rupture when this drug is used.4 At weaning (approximately six months of age), it is advisable to perform a faecal worm egg count (FWEC) to determine if treatment for strongyles is also required; the macrocyclic lactone anthelmintics (ivermectin or moxidectin) are expected to have the highest efficacy. At 9 and 12 months of age treatment for stronglyes and a larvicidal dose for encysted stages of small strongyles (moxidectin or a 5 day course of fenbendazole) are indicated. A tapeworm treatment should be included with one of these doses.2,3
For yearlings, two methods have recently been proposed for worm control: the first involves using faecal worm egg counts (FWECs) at more frequent intervals than for adults to guide dosing for strongyles in the grazing season.1 The second suggests three baseline treatments targeting strongyles in spring, summer and late autumn, with FWECs in between to identify and treat any still shedding high numbers of eggs, up to a maximum of six treatments per year.2 Macrocyclic lactones have the highest expected efficacy against small strongyles and should form the basis of treatments; however, pyrantel can be considered for some treatments where it has been shown to have continued efficacy. Both strategies include a larvcidal treatment for encysted small redworm combined with testing or treating for tapeworm in late autumn. The inclusion of one or two doses of a macrocyclic lactone each year (usually already used for small strongyle control) should be sufficient to prevent large strongyle related disease.3
The wide differences in the circumstances of foals and yearlings, together with geographical variations in resistance patterns and a lack of consensus on best practice in this group means it is not possible to define a single approach to a worming plan. An important point to note is that FWECs may give surprising results because higher counts are generally seen in youngstock.
Eight ways to keep clients' youngstock worms controlled:
For further information on worming together with some equine specific CPD visit: https://blog.vetsupportplus.com/
Richard Hepburn MRCVS has launched what is thought to be the world's first equine gastric ulcer study, designed to improve understanding and knowledge of ulceration in performance horses.
Mr Hepburn is conducting the InnerVision study of performance horses, which is being championed by the University of Liverpool, as part of his PhD.
21 appointed practices across the UK are participating in the study, and with each practice scoping between 10 and 20 animals, it will include well over 200 performance horses. Mr Hepburn said: "Gastric ulceration in sports horses is poorly understood, especially compared with racehorses. But what we do know is that it's a very important factor in the performance and well-being of many horses in training and competition."
2012 Paralympic Gold medallist Deb Criddle MBE also attended the launch event. She explained the difference that regular gastroscopy and ulcer management of Paralympic team horses had made to her success. Speaking about her Beijing ride, Pavaroti, she said: "If it weren't for the diagnosis and treatment of Pavaroti's ulcers I don't know what we'd have done. I would probably have had to withdraw him from training, so it made the difference between our partnership continuing or not".
Mr Hepburn expects a prevalence of approximately 60% and, keen to increase understanding of glandular ulceration, participants are being tasked to scope all areas of the stomach, pylorus and duodenum to ensure that every incidence of ulceration is diagnosed and recorded.
He says he is particularly eager to find out more about glandular disease, which hitherto has had little research: "Glandular disease appears to have a very different aetiology to squamous ulceration, and often presents with different signs. We also believe that prevalence of glandular ulceration is most common in sports horses."
"We hope that publication of this study will help all equine vets in their work with performance horses and the quest to prevent and manage equine ulcers," he added.
Merial is supporting the study with management assistance.
Feel Good Colic Rectals is a 20-minute online guide that uses state-of-the-art 3D modelling technology to allow you to visualise an examination of the normal equine abdomen, and to demonstrate how to differentiate abdominal abnormalities during a rectal examination.
The video features leading colic experts Professor Debra Archer BVMS PhD CertES (Soft Tissue) DipECVS MRCVS, head of equine surgery at the University of Liverpool, and Rachael Conwell BVetMed CertEM(IntMed) DECEIM MRCVS, European specialist in equine internal medicine.
To be in with a chance of winning one of 30 rectal tops, watch Feel Good Colic Rectals at www.boehringer-academy.co.uk, then answer two multiple choice questions.
A European study undertaken in horses to evaluate the efficacy of the key anthelmintic molecules fenbendazole, pyrantel, ivermectin and moxidectin in treating equine cyathostomins, has confirmed that resistance is developing against all the molecules with the exception of moxidectin.
Resistance to fenbendazole was highlighted as a particular issue with 80% of the yards tested in the UK and Germany showing resistance. Resistance to pyrantel also proved to be increasingly prevalent while cases of ivermectin resistance were emerging.
The Fort Dodge-sponsored study, the largest of its kind so far undertaken, took place during 2008 and was led by scientific teams from veterinary faculties in Italy and Germany. It was based on Faecal Egg Count Reduction Tests (FECRTs) of 1,704 horses at 102 yards in Italy, Germany and the UK. The calculation of FECR data was performed employing bootstrap analysis of group arithmetic means.
The study concluded that:
According to Dr Donato Traversa from the University of Teramo, Italy, who headed up the field work, the results confirm that single and even multiple drug resistance in equine cyathostomins is an increasing challenge in all three countries with resistance to fenbendazole and pyrantel a particular concern.
He said: "Our research highlights the necessity for vets, owners and managers to use those anthelmintic molecules that remain most effective in a manner which preserves their efficacy for as long as possible."
Professor Georg von Samson Himmelstjerna from Hannover University of Veterinary Medicine, which participated in the research, added: "Given the strong impact that resistant cyathostomins are likely to have on horse welfare, future parasite control plans should be based on integrated measures, involving both the correct use of anthelmintics, such as administering the correct dosing according to the animals weight, and only using products in the species for which it is licensed, as well as other approaches such as adequate pasture hygiene, low stocking rates and mixed grazing with other animals.
"We call on all concerned with equine health and welfare to take an active role in planning and monitoring effective worm control programs."
Jonathon is an RCVS & EBVS European Specialist in Veterinary Diagnostic Imaging, with a particular interest in MRI of the distal limb and has published scientific work on this subject, among others.
With the increase in availability and accessibility to CT for horses, VetCT says this hot topic will be well received by equine vets at all levels of experience.
VetCT’s Equine Teleradiology Manager, Charlotte Graham, said: “We can guarantee a highly engaging talk with plenty of useful tips on case selection for each modality as well as some interesting discussions in the Q&A session.”
To register for the webinar on 18th April and receive links to recordings of this and previous webinars in the 2023 series, sign up here: https://vetct.zoom.us/webinar/register/WN_zkctYZYWRUmRVIFTxrvvsA
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