ACP tablets?

RE: ACP tablets?

Beats — Fri, 19 Dec 2025 07:49:31 GMT

I was taught this was a myth years ago at uni, but only last week was confused when considering giving acp to a dog on fluoxetine to help get its hair cut. Bsava formulary under fluoxetine lists under drug interactions not to mix with phenothiazines due to seizure risk? Didn't know if this was something new or something very old?

RE: ACP tablets?

David Mills — Fri, 19 Dec 2025 02:39:01 GMT

Fun fact re ACP lowering the seizure threshold is nonsense. It's based on a 1950s study in human using phenothiazines at 5x + the recommended dose in order to try and induce seizures.

So the "don't use in epileptic dogs" nonsense still taught is just that. There's even some vet studies into acp showing it doesn't make dogs have seizures.

www.mspca.org/.../Michaels_Mythbusters-Neurology-and-Pharmaceuticals-Edition_October-2024-1.pdf

RE: ACP tablets?

Beats — Fri, 05 Dec 2025 22:14:53 GMT

Merlin Vet (Merlin Vet UK – UK veterinary wholesaler expertly sourcing and supplying veterinary products to veterinary surgeons, clinics, distributors and wholesalers worldwide) can source you 10mg acepromazine maleate tablets (PromAce, USA) with an SIC. Price was reasonable to me that I would still expect to use them (often only small number of tablets at a time per dog) and shelf-life variable with size of pot, I got Feb 2027 with a pot of 100 does me fine (we average 50 tablets per month presently).

I did not find a present means of procuring any of the many EU formulations without ordering an amount far beyond what I would ever use at our clinic.

RE: ACP tablets?

Michael Woodhouse — Thu, 27 Nov 2025 21:25:03 GMT

[quote userid="9440" url="~/f/non-clinical-questions/31273/acp-tablets/248067#248067"]anyone ever used human chlorpromazine? [/quote]

my wife! Would consider it in dogs

RE: ACP tablets?

janine redman — Thu, 27 Nov 2025 12:11:05 GMT

They are better for post op sedation or dogs that stress overnight. The fallacy that they were inappropriate because they allow dogs to experience fear but not be able to respond to it was always a really odd claim and they don’t cause the ataxia and changes in behaviour that gabapentin does .
great for long journeys where nausea a factor and other situations too.

anyone ever used human chlorpromazine?

RE: ACP tablets?

Michael Woodhouse — Wed, 26 Nov 2025 23:55:11 GMT

[quote userid="9440" url="~/f/non-clinical-questions/31273/acp-tablets/248064#248064"]The anti emetic and sedation combined with anxiety relief was a really nice medicine for many patients [/quote]

They seem to be like the modern day pred with new grads - the behaviourists have gotten to them and told them they are the spawn of the devil and you mustn't use. I liked them for so many things (inc fireworks.....), nothing as good orally for a nasty dog to PTS. Suspect sales plummeted in the last 20 years - you'd need a great PR campaign and some rebelief that they do, like the data sheet always said, reduce anxiety........

RE: ACP tablets?

Beats — Wed, 26 Nov 2025 21:45:43 GMT

I liked the tablets but if might not be coming back guess time to look at alternatives. Any Spanish gets with a view on the aceprovet oral solution from experience to share? medicines.health.europa.eu/.../cdbb427c-9b48-4af4-8037-f4a509cd31b5

RE: ACP tablets?

janine redman — Wed, 26 Nov 2025 18:11:24 GMT

I used my last few this week, they are so useful in certain situations and I would love to find a source for them , perhaps Bova or summit could step Up ? The anti emetic and sedation combined with anxiety relief was a really nice medicine for many patients

RE: ACP tablets?

Rob Loxley — Wed, 26 Nov 2025 08:32:05 GMT

I understood it was discontinued. I suspect OTM use of the injectable may be the answer

RE: ACP tablets?

Ben Walker — Tue, 25 Nov 2025 22:53:29 GMT

The marketing authorisation expired in September so I’m guessing actually discontinued, for now at least:

https://www.vmd.defra.gov.uk/productinformationdatabase/product/A003094