Atrial fibrillation?

RE: Atrial fibrillation?

Evelyn Barbour-Hill — Mon, 04 Dec 2017 14:03:38 GMT

[quote user="Anthony Todd"]

I/we started using Maxolon in about 1972 in NZ when it first came out for humans. Have there ever been any animal trials for it yet?

[Probably now that it's a nice little earner, and they need some sort of "data" for the generical copycats to get a licence and expand the price.]

[/quote]

Done, they called it Emequell, now there's Vomend.

RE: Atrial fibrillation?

Anthony Todd — Mon, 04 Dec 2017 13:57:06 GMT

[quote user="Martin Atkinson"]

[quote user="Anthony Todd"]Funny how what dinovets did years ago is suddenly becoming acceptable..[/quote]I'm not so sure about that in the vast majority of cases Anthony. I used Pimobendan when it first came out largely because I was always looking for the cutting edge and willing to try something new and found it worked miracles. I suspect a great number of 'dinovets' hadn't even heard of it let alone tried it.

[/quote]

You make my point so well...

I/we started using Maxolon in about 1972 in NZ when it first came out for humans. Have there ever been any animal trials for it yet?

[Probably now that it's a nice little earner, and they need some sort of "data" for the generical copycats to get a licence and expand the price.]

RE: Atrial fibrillation?

Martin Atkinson — Mon, 04 Dec 2017 09:12:05 GMT

RE: Atrial fibrillation?

Anthony Todd — Sat, 02 Dec 2017 12:06:36 GMT

[quote user="Martin Atkinson"]Now if that doesn't get a response form DM nothing will[/quote]

Funny how what dinovets did years ago is suddenly becoming acceptable..

RMM's cartoon "I just want the dog to get better Doc, so skip the lab tests" is apposite again.

RE: Atrial fibrillation?

Rob Loxley — Fri, 01 Dec 2017 20:24:26 GMT

There's an article that talks about rate control in AF in this week's Vet Times

RE: Atrial fibrillation?

Martin Atkinson — Fri, 01 Dec 2017 18:26:08 GMT

[quote user="Julian Earl"]I stand corrected Martin. I think that I meant DCM, but the dropped pulses and tachycardia plus grey-white MMs responded well to the Vetmedin, regardless![/quote]I note also again a sentence in your OP: 'I started using pimendoban and my first case showed such dramatic improvement that it became my first-line treatment'.

I started using Pimobendan the moment it became available, before some of the cardiologists, for dogs with CHF due to mitral valve disease which had become refractory to other available medication. Ditto Dobermans in the final stages of DCM. The response in both was dramatic and increased the life expectancy of the Dobies by 18 months on average. I subsequently started it as my first line treatment in at risk dogs, I didn't need EPIC, QUEST or any other acronym trial to tell me this.

Now if that doesn't get a response form DM nothing will.

RE: Atrial fibrillation?

Julian Earl — Fri, 01 Dec 2017 16:52:23 GMT

I stand corrected Martin. I think that I meant DCM, but the dropped pulses and tachycardia plus grey-white MMs responded well to the Vetmedin, regardless!

I am going off memory of cases five years ago, so please forgive any inaccuracies as a result. I remember them, rightly or wrongly as AF for whatever reason...!

RE: Atrial fibrillation?

Martin Atkinson — Fri, 01 Dec 2017 14:32:22 GMT

A) You can't make an assumption that an arrhythmia is due to AF without an ECG.

B) You're not likely to correct AF without cardioversion which isn't likely to happen in our patients so treatment is aimed at controlling the resultant ventricular arrhythmia,

C) I think digoxin has had its day, a beta blocker or calcium channel blocker like Diltiazem may be effective but may be harmful if the dog is surviving on an escape rhythm (hence the need for an ECG). We know Pimobendan is useful especially in dogs with DCM which this dog is likely to have given its breed, but it will help control the arrhythmia as well, presumably due to its mode of action to sensitise the myocardium to calcium, similarly to a calcium channel blocker but don't use both together!

D) No doubt DM will be on to contradict all this!