Struggling to get phenoxybenzamine (dibenyline)

Re: Struggling to get phenoxybenzamine (dibenyline)

Martin Atkinson — Tue, 14 Apr 2015 15:40:16 GMT

[quote user="Will McMullan"]I have seen a number of cases with no uroliths, so I assume either mucoid plug or urethral spasm.[/quote]For mucoid plug read urolithiasis/UTI - OK there may not be any frank uroliths but those 'mucoid plugs' have always contained some crystals or inflammatory cells IME. If there is a urethral spasm again there must be a trigger so maybe a UTI. So once again IMO the effort is better spent concentrating on investigating/treating the cause rather than the effect.

Re: Struggling to get phenoxybenzamine (dibenyline)

Will McMullan — Tue, 14 Apr 2015 14:47:08 GMT

I have seen a number of cases with no uroliths, so I assume either mucoid plug or urethral spasm. I catheterised one of them without meeting any resistance at all (can't remember if it was sedation or GA) and have always thought that could have been spasm. It didn't recur in the short term, don't know about long term.

Re: Struggling to get phenoxybenzamine (dibenyline)

Martin Atkinson — Tue, 14 Apr 2015 10:30:48 GMT

[quote user="Francisco Gomez"]Thought as far as I remember is not that clear that urolithiasis is the main cause of the problem[/quote] It is difficult to see what else would have been the initial trigger and I know some cats do get urethral spasms post un-blocking but I've yet to hear of one where spontaneous urethral spasms were the primary problem. Equally I'm happy to be corrected.

Re: Struggling to get phenoxybenzamine (dibenyline)

Francisco Gomez — Mon, 13 Apr 2015 19:51:32 GMT

Guess u're right... I've been asked the question and I wasn't that sure myself. Thought as far as I remember is not that clear that urolithiasis is the main cause of the problem... happy to be corrected. Thank u Martin

Re: Struggling to get phenoxybenzamine (dibenyline)

Martin Atkinson — Mon, 13 Apr 2015 16:59:12 GMT

First I've got a dog with a suspected phaecochromocytoma on it and had no problem sourcing it from NVS a couple of weeks ago.

Second unless the cat is persistently dysuric I can't see the benefit of long term therapy, surely management should be aimed at prevention of recurrence of urolithiasis.