Niacillin/Doxycycline/Pred/EFA doses!!!

Re: Niacillin/Doxycycline/Pred/EFA doses!!!

Yantha Smyth — Wed, 07 Nov 2012 18:49:00 GMT

I do a lot of Greyhound work and we see SLO very frequently in this practice. We trim back and remove loose nails after a hibi soak under GA, put on some abs and opioid analgesia in the short term; we avoid the pred due to excessive side effects in this breed. The mainstay of our treatment is Onychotin (Biotin) 1 daily (a pot of 100 approx £15 to the client) ongoing, and Trental (pentoxifylline) 10-15mg/kg BID (fairly expensive) for many months.

Re: Niacillin/Doxycycline/Pred/EFA doses!!!

Emily Nightingale — Tue, 06 Nov 2012 16:43:56 GMT

Just a follow up! it's 8 weeks since the OP, and the dog is doing BRILLIANTLY! Minimally pu/pd on 20mg pred BID for first 6 weeks now cutting down fortnightly to current dose of 10mg BID, Oxytet stopped, EFA, VitE and Niacinamide continuing and her nails are looking solid, nail beds normal and no lameness.

One thing I have noticed is her eyes look rather bulgy though (O has noticed this too) and I'm wondering if there is a cause for this? I dont have a tonometer but retropulsion is well tolerated and there is no sign of any other ocular pathology. My first assessment (ok..guess..) was steroid induced muscle atrophy of the temporal and masseter muscles which might make her eyelids retract a little?? Anyone any thoughts on this?

This aside however, the patient is doing great. So thank you for all you treatment suggestions.

/ Emily

Re: Niacillin/Doxycycline/Pred/EFA doses!!!

Rob Loxley — Wed, 29 Aug 2012 00:10:03 GMT

we have a couple doing well on niacinamide and oxytet

Re: Niacillin/Doxycycline/Pred/EFA doses!!!

Emily Nightingale — Tue, 28 Aug 2012 23:09:23 GMT

Thank you all very much!! V much appreciated. Re. the Niacillin - I was wondering why I couldnt find it anywhere. Am sure that's what the clever lady at Idexx suggested but then the reception on my phone was a little dodgy at the time. Many thanks- am very grateful!

(thats a thumbs up WITH fingernais intact =)

Re: Niacillin/Doxycycline/Pred/EFA doses!!!

Joyce Whitehead — Tue, 28 Aug 2012 21:52:19 GMT

We have had a couple of these in the last few years - both of which have been on Nicotinamide (250mg as described above - both dogs were about 15kg), EFAs - both were on double standard dose of Coatex, and oxytet, 250mg daily. Not sure where we came up with the doses but they both coped/are coping well (one pts for other reasons). Be prepared to lose most of the nails in the first couple of months, or to have lots of broken ones, but then our ones seemed to get to a stage where they have very short, soft nails, but don't very often have a break, so no pain.

Hope that helps!

Re: Niacillin/Doxycycline/Pred/EFA doses!!!

Mark Norcott — Tue, 28 Aug 2012 17:34:06 GMT

I have never used that combo myself.

I have used high dose EFAs as outlined above along with biotin (Onychotin) with good success. Vitamin E also is suggested.

Re: Niacillin/Doxycycline/Pred/EFA doses!!!

Rajat — Tue, 28 Aug 2012 16:43:52 GMT

I use a standard dose of 30-40mg/kg EPA and 10mg/kg DHA of EFAs in dogs and cats with inflammatory conditions (Osteoarthritis, heart failure, CRF..)

You can use Go-omega which is high dose EFAs, or Yumove plus which is also supposedly high dose(though I haven't looked into it much at all)

Alternatively Cardisure by boehringer has fairly high doses of Omega 3s again not sure of quantities

If O doesn't mind a (very) fishy smell Go omega is quite good. Alternatively a high quality (eg seven seas)OTC supplement may be an alternative.

Re: Niacillin/Doxycycline/Pred/EFA doses!!!

Utlendigur — Tue, 28 Aug 2012 16:14:49 GMT

We've got one case on the go at the moment but I'm not at work today - will look it up tomorrow if nobody else has replied.

By Niacillin I think you might mean Niacinamide (Nicotinamide) - dose for that in the bsava formulary is 250mg tid for dogs up to 25kg.