Osteosarcoma - pain relief

Re: Osteosarcoma - pain relief

Anthony Todd — Fri, 23 Sep 2011 01:17:17 GMT

Endone - Oxycodone hydrochloride

This seems to be the current favourite in Queensland, cheapish, and very effective when the others weren't, in my case.

Re: Osteosarcoma - pain relief

KathW — Tue, 20 Sep 2011 15:14:04 GMT

Many Thanks for the replies. Think I'll go for gabapentin as 3rd drug if needed - at the moment dog seems a better on tramadol tid.

Re: Osteosarcoma - pain relief

Laurence Webb — Mon, 19 Sep 2011 21:54:23 GMT

The last osteosarcoma I had I put onto NSAID, paracetemol (pardale has codine in it too), tramadol, gabapentin and amantidine then added in more codine as required. The improvement in analgesia was impressive - it went from 10/10 lame to jumping around so much that I feared it would break the leg. Once it deteriorated the owners elected for euthanasia before I gave it stronger opiates.

Bisphosphonates are reputed to be effective in some cases. I've only used them once and the 'best' one (as advised by an oncologist, Zometa) had no effect in that case and is mighty expensive. Others are cheaper but may be even less effective!

Re: Osteosarcoma - pain relief

Joyce Whitehead — Mon, 19 Sep 2011 20:41:42 GMT

I've had dogs on NSAID, tramadol and gabapentin to control severe pain, seems to be a good top up method.

Re: Osteosarcoma - pain relief

Andrew Kent — Mon, 19 Sep 2011 19:34:22 GMT

Bisphosphanates are used in people for osteolytic bone pain but most work is on IV agents (eg pamidronate or zaledronate)

See: The bone biologic effects of zoledronate in healthy dogs and dogs with malignant osteolysis

J Vet Intern Med. 2008 Mar-Apr;22(2):380-7.

You could try alendronate (fosamax) orally but bioavailability is not thought to be great. Dose is 70mg every 2 days in large dogs, follow with food/water.

Andy

Re: Osteosarcoma - pain relief

Dagmar Steele — Mon, 19 Sep 2011 19:27:06 GMT

what about the bisphosphonates, they are supposed to be a suitable palliative treatment. Never used them myself though, as the last cases were all either amputated or pts.

Re: Osteosarcoma - pain relief

Mark Holmes — Mon, 19 Sep 2011 19:05:58 GMT

The last osteosarcoma I treated was on NSAID, Paracetamol and oral morphine tablets.