https://www.vetsurgeon.org/f/clinical-questions/9332/pyloric-carcinoma 10 yo cocker with a carcinoma in ploric muscularis externa but thickend lymphatics/fat extending into the duodenum. being treated paliatively and I do not feel radical resection would be fair as this may not be the primary. Any chemo sugestions or anyen-USTelligent Community 10https://www.vetsurgeon.org/thread/45323?ContentTypeID=1Sat, 17 Sep 2011 08:55:20 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:ad803b42-ab3e-4fd4-986a-5eaae0b594beRichard Fox<p>&quot;Masivet is of course primarily designed for mast cell tumours&nbsp;but there is evidence as I understand it&nbsp;to suggest that as inflammation plays a big part in metastatic spread and mast cells play a big part in inflammation masitinib may limit metastases or at least the impact of them and therefore has a role in treatment of other tumours, by allowing unaffected cells to &#39;fight back&#39;&nbsp;and sensitise tumour cells to other forms of chemotherapy.&quot;</p> <p>I was aware that multistep mutagenesis was the main method that tumour cells acquire an in invasive and or metastatic phenotype - many malignant neoplasms are not associated with inflammation. I have not heard of mast cells being directly involved in carcinoma metastastasis Martin - have you a reference for this as I would be interested?</p> <p>I am afraid I would prepare the owners for the worst myself?</p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/45221?ContentTypeID=1Thu, 15 Sep 2011 18:27:39 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:77291ab3-4cf5-48e4-b768-7efb235f87b3Martin Atkinson<p>Masivet is of course primarily designed for mast cell tumours&nbsp;but there is evidence as I understand it&nbsp;to suggest that as inflammation plays a big part in metastatic spread and mast cells play a big part in inflammation masitinib may limit metastases or at least the impact of them and therefore has a role in treatment of other tumours, by allowing unaffected cells to &#39;fight back&#39;&nbsp;and sensitise tumour cells to other forms of chemotherapy. It can&#39;t be any more harmful than not doing anything&nbsp;as long as the client is aware that there are side effects. So far as I&nbsp; am aware there is not much else that is worth trying in the chemo field.</p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/45195?ContentTypeID=1Thu, 15 Sep 2011 16:40:33 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:fda87fb7-b2cb-4004-bae5-2287bf00400bMark Rowland<p>Sounds like a phonecall to the VRCC is in order <img src="https://www.vetsurgeon.org/emoticons/v2/Light.png" alt="Idea" /></p><div style="clear:both;"></div>