Alizin in pyos

Re: Alizin in pyos

Rebecca MacMillan — Fri, 14 Jun 2013 18:30:56 GMT

I've used it before in an elderly westie who had an open pyo. She presented just off colour I think, so wasn't massively dehydrated or anything, but she had been leaking pus from her vulva - which the owners had failed to spot. Her owner was really not keen to go for surgery as the dog had not long had a cruciate op, so finances were tight! She did really well actually, I administered the first two alizin injections, and she was supposed to have a 3rd a week later, which my boss neglected to do for some reason (ignored my notes/instructions!) but she was still fine without it. The plan was to neuter her once she was back to normal before her next season, but I'm not sure that her owners ever booked her in for that....

Re: Alizin in pyos

Anthony Dennison — Fri, 14 Jun 2013 12:53:06 GMT

I was very sceptical about the medical treatment of pyos whilst at uni. Since graduating it's actually often the first option I go for, especially as most of the clients who turn up have left it for at least a few days, or they have very little money. Although Alizin is expensive, it's usually cheaper than the op for us, and once sorted a lot of owners will get the neutering voucher from Dogs Trust.

Re: Alizin in pyos

mariette asselbergs — Fri, 14 Jun 2013 11:58:54 GMT

For the record:

I have just used alizin plus amoxycillin/clav on a very fat over 14 year old xbreed bitch which has kidney failure under control on kidney diet, high liver enzymes and mammary tumours (multiple hard well defined nodules). Had been discharging blood for more than 6 weeks, drinking loads but appetite not affected, quite perky in itself, no vomitus. Discussed pros and cons and risk of surgery in the face of life expectancy and owner opted for alizin. I will report on the follow up. The dog is called Lucky......!

Mariette

Re: Alizin in pyos

Alan Tevendale — Fri, 22 Jul 2011 15:56:24 GMT

Will that not depend on how quickly the cervix opens and how near to rupture the uterus was. Is handling the dog prior to surgery not also a risk?

Re: Alizin in pyos

Bob Russell — Fri, 22 Jul 2011 15:54:14 GMT

[quote user="Martin Atkinson"]

I had a pyo in last week and due to financial circumstances was considering Alizin. We elected for surgery in the end and the uterus was on the point of rupture so I'm glad I took that option. Does anyone have any experience of uterine rupture following Alizin, must be a risk?

[/quote]

As I understand it Alizin causes the cervix to open and gravity/abdominal pressure does the rest.

Re: Alizin in pyos

Martin Atkinson — Fri, 22 Jul 2011 13:05:27 GMT

Re: Alizin in pyos

HMC — Fri, 22 Jul 2011 09:51:23 GMT

[quote user="bob lehner"]Interestingly on a recent Virbac Webinar figures were quoted of only 10% recurrence at the next season after treating pyos with Alizin [/quote]

I heard this too. It makes me seriously think about the idea of not spaying in certain situations (recent case of a horrendously overweight Lab belonging to an owner with many overweight Labs, so my chances of getting them to diet this particular dog was slim-to-none).

Re: Alizin in pyos

James Allsop — Wed, 20 Jul 2011 16:16:33 GMT

[quote user="bob lehner"]Interestingly on a recent Virbac Webinar figures were quoted of only 10% recurrence at the next season after treating pyos with Alizin - and a 50% pregnancy rate in those mated at the next season. Even the speaker seemed to express some surprise at these figures. Instinctively one would expect a very high recurrence rate at the next season.[/quote]

About 2yrs ago i attended a virbac seminar on repro drugs where the speaker (repro 'sepcialist' MRCVS) discussed the use of alizin for pyo and was in favour of its use. She recommend spaying before next season or mating at next season as (and i quote from memory - which can be a little hazy at times ) almost 100% with have a pyo at the next season unless you get them pregnant.

Re: Alizin in pyos

bob lehner — Wed, 20 Jul 2011 09:45:51 GMT

[quote user="fluffygirl"]Used Alizin in combination with Galastop on a Staffie bitch with a closed pyo whose owner insisted she wanted to breed from the dog and refused to spay it. Works a treat for turning a closed pyo into an open one, but I would only use it as a short term measure with the ultimate aim of spaying long term. Even if you get them over this one the likelihood is they will develop another pyo at the next season.[/quote]

Interestingly on a recent Virbac Webinar figures were quoted of only 10% recurrence at the next season after treating pyos with Alizin - and a 50% pregnancy rate in those mated at the next season. Even the speaker seemed to express some surprise at these figures. Instinctively one would expect a very high recurrence rate at the next season.

Re: Alizin in pyos

Bob Russell — Mon, 18 Jul 2011 11:51:12 GMT

I have found that a single injection of Alizin converts a closed pyo to an open one overnight and a miserable patient into a much happier one. I always spay them before the next season. Some I spay next day. it is amazing how rapidly their hydration returns to normal once the pus flows!

Re: Alizin in pyos

fluffygirl — Sun, 17 Jul 2011 16:38:44 GMT

Used Alizin in combination with Galastop on a Staffie bitch with a closed pyo whose owner insisted she wanted to breed from the dog and refused to spay it. Works a treat for turning a closed pyo into an open one, but I would only use it as a short term measure with the ultimate aim of spaying long term. Even if you get them over this one the likelihood is they will develop another pyo at the next season.

Re: Alizin in pyos

Jillian Hall — Sun, 17 Jul 2011 16:29:28 GMT

I've used Alizin and anitibiotics very successfully for a closed pyo. Pretty ideal case as it came in late on a Sunday night, was pretty bright and well, and owners had limited funds. Could have spayed Monday morning if Alizin wasn't working. But by morning it had filled it's kennel with pus and was bouncy and eating well. That was about 3 weeks ago and doing fine as far as I know.

My only tip would be to warn owners of the mess if they're taking the dog home - (or the nurses if it's staying in.) A kilo+ of pus spread all over the house won't be pretty.

Re: Alizin in pyos

Julian Earl — Sun, 17 Jul 2011 10:28:44 GMT

[quote user="Mark Holmes"]I once had a pyo that ruptured as I went to exteriorise the uterus. I managed to keep the discharge out of the abdominal cavity but the result was an arc of foetid pus which cleared the heads of those close and his the cupboards on the other side of the room. The nurse stood there managed a CSI style dive and roll with remarkable agility given her age. The result was a clean abdomen and wall to wall pus in the theatre.

[/quote]

I had a labrador a couple of years that weighed 25.75kg pre-op, and 21.85kg post-op. That uterus also ruptured on the point of removal - unfortunately my nurse did not manage to dive out of the way. Sorry B. Still at least the walls stayed clean.

Re: Alizin in pyos

Mark Hedberg — Sun, 17 Jul 2011 09:53:02 GMT

Epic. :) well caught!

Re: Alizin in pyos

Mark Holmes — Sun, 17 Jul 2011 08:25:08 GMT

I once had a pyo that ruptured as I went to exteriorise the uterus. I managed to keep the discharge out of the abdominal cavity but the result was an arc of foetid pus which cleared the heads of those close and his the cupboards on the other side of the room. The nurse stood there managed a CSI style dive and roll with remarkable agility given her age. The result was a clean abdomen and wall to wall pus in the theatre.

Re: Alizin in pyos

Mark Hedberg — Sun, 17 Jul 2011 07:19:46 GMT

Wasn't saying it was easy; just that it wasn't blue. ;) (i'd prefer not to try a case like that again, in fact - bit of luck and divine intervention that it hadn't ruptured already. )

Nice graph!

Re: Alizin in pyos

Michael Woodhouse — Sun, 17 Jul 2011 00:04:19 GMT

[quote user="Mark Hedberg"]Well, 74 to 94. Wasn't blue - just a bit panty :D[/quote]

It's a curve remember - less than 90% and things are going bad

Re: Alizin in pyos

Mark Hedberg — Sat, 16 Jul 2011 22:50:23 GMT

[quote user="Thomas Ward"]

[quote user="Mark Hedberg"]

(The o2 saturation went up a good twenty points when I finally exteriorized the thing)

[/quote]

Crikey! Was the dog blue for most of the op??

[/quote]Well, 74 to 94. Wasn't blue - just a bit panty :D

Re: Alizin in pyos

Stephen Courtney — Sat, 16 Jul 2011 22:09:57 GMT

Just used it in a rat with a pyo. Has the first 2 injections with good results, is due the third on Monday. when she is well, our exotics lady will spay her.

I used the guinea pig dose out the formulary, 10mg/kg on day 1,2 and 8.

Will be looking for a dog to use it on but there is a certain leap of faith required...!

Re: Alizin in pyos

plantagenet — Sat, 16 Jul 2011 21:46:36 GMT

Used it for the first time in a hugely overweight aggressive rotti - d1,2,7 + 14

Excellent results and she is on a major diet now, ideally would have spayed her a few weeks after last inj. but she is so gross that I'm going to delay for weight loss and hope she doesn't get repeat pyo next season, which I appreciate she might.

Trying to get a mega amount of Alizin, no more than 5ml in each site, into a snarling guard dog was not the most pleasant experience but on balance less unpleasant than wading through blubber internally and trying to maintain her on a drip. Might book my holiday for when she's spayed.

Re: Alizin in pyos

SteveOwen — Sat, 16 Jul 2011 18:44:59 GMT

Why only in open pyos? Works just as well in closed :-/

Re: Alizin in pyos

jose targa — Thu, 07 Jul 2011 11:33:53 GMT

We have been using it for years, with relatively good results (allways in opened pyos!!!! jajajaja) we don´t have experience with only alizin as a sole treatment, allways look for antibiothic to combine with.

Regards from Spain.

Re: Alizin in pyos

Bob Russell — Thu, 07 Jul 2011 10:04:16 GMT

We have used it with good results. The gunk usually flows within 24 hours and the dog brightens up dramatically. I tend to use it in the very high risk patients.

There have been previous threads on the subject and it has been questioned whether it is worth it rather than just operating. I think it often is!

Re: Alizin in pyos

Tom Ward — Thu, 07 Jul 2011 09:27:04 GMT

[quote user="Mark Hedberg"]

(The o2 saturation went up a good twenty points when I finally exteriorized the thing)

[/quote]

Crikey! Was the dog blue for most of the op??

Re: Alizin in pyos

Mark Hedberg — Wed, 06 Jul 2011 23:16:31 GMT

I had a staffie a few months ago - 20kg presurgery. 17kg postsurgery. We had other staff members coming in just to see the uterus. (The o2 saturation went up a good twenty points when I finally exteriorized the thing)

I read the article too; I mean to try alizin; just the last case I had in (not the staffie above) I didn't feel was an ideal candidate. (Old dog with multiple issues and didn't want to mess around too much.)