Hyperglobulinemia of unknown cause

Re: Hyperglobulinemia of unknown cause

Stephen Courtney — Wed, 20 Apr 2011 22:02:02 GMT

I think you need a urine sample, admit the cat and wait till he obliges with a full bladder? Hard to know what to do without repeating everything that has gone before, but haematology would be helpful too.

Re: Hyperglobulinemia of unknown cause

Utlendigur — Wed, 20 Apr 2011 21:37:18 GMT

[quote user="Busybee"]Wouldn't you expect more of a diarrhoea with IBD?[/quote]

Just gone back and reread "constipation" - I just saw the defaecating in house bit (and polyphagia, weight loss and low Alb) and jumped to conclusions. But given TP is high that might be enough to give good enough fluid resorption in colon to mask D+? I actually lost one of my dogs to IBD earlier this year (acute exacerbation of what was probably chronic and asymptomatic problem) and initially she didn't really have D+ - presenting sign was mainly pupd (but then she was a staff dog so presenting a la textbook is forbidden) - and the D+ tended to reduce after iv colloids also.

Re: Hyperglobulinemia of unknown cause

Richard Fox — Wed, 20 Apr 2011 14:15:59 GMT

FIP? - Age would be a little more unusual (an albumin globulin ratio of < 0.6 is highly diagnostic for an inflammatory process, nearly exclusively for FIP) (sorry copied from my last post ) - your ratio is about 5.7 so not far off! Even if the FCoV is -ve?

Re: Hyperglobulinemia of unknown cause

Busybee — Wed, 20 Apr 2011 13:55:40 GMT

Wouldn't you expect more of a diarrhoea with IBD? No obvious intestinal neoplasia on ultrasound though could always be diffuse. Urine sample would be nice and that would be a definite choice of mine but cat doesn't normally use litter tray and bladder is always small when seen. Could keep hospitalised though would take a lot of owner persuading! Haematology and smear was done and nothing abnormal detected. Second lot of bloods due today....!

Re: Hyperglobulinemia of unknown cause

Utlendigur — Tue, 19 Apr 2011 21:39:23 GMT

Albumin is very low also. Given the weight loss and polyphagia what about protein losing enteropathy (IBD, intestinal neoplasia etc) or protein losing nephropathy it it's urinating in the house. Urine sample including protein/creatinine ratio to r/o proteinuria? I wonder whether the high globulins are masking the usual effects of hypolabuminaemia (ascites, D+, oedema). Not sure whether the blood profile included haematology but that would probably be worthwhile including smear exam.