Hypophosphataemia, hypokalaemia seizures

Re: Hypophosphataemia, hypokalaemia seizures

Alan Tevendale — Sun, 10 Apr 2011 07:06:17 GMT

Well the dog is looking fairly good now. Had another seizure and since has started on anti-epileptics but the last couple of blood samples have come back normal now so looks like the hypophosphataemia and hypokalaemia were temporary. Still, I never definatively worked out why. Neither have any of the medicine specialists I've spoken to been able to explain things fully.

Just put it down to experience.

I'll probably get another one next week

Re: Hypophosphataemia, hypokalaemia seizures

Alexander Campbell — Sat, 09 Apr 2011 16:36:27 GMT

[quote user="Laurence Webb"]

Can Xylitol interfere with glucose assays? Hyperinsulinaemia could then cause the hypophosphataemia

[/quote]

Hi all

probably a bit late now but I;ve spoken to some of our clinical biochemists here about assay interference.

One has responded to say he'd had a look around and talked to a few people, but could find no indication that xylitol interferes with any of the common blood sugar testing systems. Plenty of indications that xylitol lowers blood sugars in dogs, but nothing that indicates an apparent rise in blood sugar.

Cheers

Re: Hypophosphataemia, hypokalaemia seizures

Laurence Webb — Mon, 04 Apr 2011 22:44:21 GMT

[quote user="Mark Hedberg"]

[quote user="Laurence Webb"]

Can Xylitol interfere with glucose assays? Hyperinsulinaemia could then cause the hypophosphataemia

[/quote]

Why, did the dog get into chewing gum?

[/quote]No idea. Just musing about toxic causes of hypophosphataemia and inappropriate insulin secretion may be possible. Mind you, xylitol is is lots of other things beside chewing gum

Re: Hypophosphataemia, hypokalaemia seizures

Mark Hedberg — Mon, 04 Apr 2011 20:48:52 GMT

[quote user="Laurence Webb"]

Can Xylitol interfere with glucose assays? Hyperinsulinaemia could then cause the hypophosphataemia

[/quote]

Why, did the dog get into chewing gum?

Re: Hypophosphataemia, hypokalaemia seizures

Laurence Webb — Mon, 04 Apr 2011 19:04:44 GMT

Can Xylitol interfere with glucose assays? Hyperinsulinaemia could then cause the hypophosphataemia

Re: Hypophosphataemia, hypokalaemia seizures

Alexander Campbell — Mon, 04 Apr 2011 18:16:19 GMT

Sorry - ignore the vit D stuff in my last message - have just looked again - and realised you had hypophos!

tremorgenic mycotoxins might still be a cause however.

Alex

Re: Hypophosphataemia, hypokalaemia seizures

Alexander Campbell — Mon, 04 Apr 2011 18:09:08 GMT

If you were looking at possible tox causes I;d suggest the eating of rotting food or compost (tremorgenic mycotoxins), or perhaps vitamin D toxicity.

What is the calcium doing? Often with Vit d tox you see a rise in phos some 6 hours prior to hypercalcaemia developing...

Most common cause of vit d toxicosis is now these vitamin D based psoriasis treatments (creams and ointments) used in humans.

Just some thoughts!

Cheers

Alex

Re: Hypophosphataemia, hypokalaemia seizures

Alan Tevendale — Mon, 04 Apr 2011 07:26:50 GMT

No unfortunately no urine sample. I'm not entirely convinced the K & Phos and responsible for the seizures either. The dog was started on diazepam yesterday and so far hasn't had another seizure.

Re: Hypophosphataemia, hypokalaemia seizures

Utlendigur — Sun, 03 Apr 2011 21:37:56 GMT

Did you manage to get a urine sample pre-fluids for specific gravity?

Re: Hypophosphataemia, hypokalaemia seizures

Busybee — Sun, 03 Apr 2011 20:31:17 GMT

Any chance of toxin exposure?

Re: Hypophosphataemia, hypokalaemia seizures

Michael Woodhouse — Sun, 03 Apr 2011 19:46:05 GMT

Have you given the dog any diazepam?

I'm not convinced that your low P&K is the cause of the seizures.