Quick Doxorubicin question

Re: Quick Doxorubicin question

Rob Loxley — Sun, 12 Dec 2010 23:07:39 GMT

[quote user="Bob Russell"]last time could not find anyone to mix it up for us[/quote]

last we bought came ready-constituted

Re: Quick Doxorubicin question

Bob Russell — Fri, 10 Dec 2010 10:01:53 GMT

I would agree - little overload risk. Keep the fluid running full pelt from a paediatric giving set. We have not had good long-term results with dox but miraculous short term improvement. It also gives our neighbours a laugh as I mix it up outside, gowned up, face shield and at least two pairs of gloves. Not quite as official H&S recommendations but the best we can manage in a small practice.

We don't have a fume cupboard and last time could not find anyone to mix it up for us. Apparently even limited indirect contact has shown to cause significant bone marrow depression in humans!

Re: Quick Doxorubicin question

Martin Atkinson — Fri, 10 Dec 2010 09:23:12 GMT

I would use a 100ml bag of saline, with same advise as above, then there's no risk of overload, cat's are pretty resistant to that anyway.

Re: Quick Doxorubicin question

Rob Reid — Thu, 09 Dec 2010 22:56:03 GMT

For a cat, I use a paediatric set and I open it fully to give. Even over 10 minutes, you won't run enough fluid in to damage the cat. Don't forget to give an anti-histamine or steroid beforehand (I usually give chlorphenamine i/v in dogs and dexadresson i/v in cats) and use 0.9% saline for your i/v fluid.

Re: Quick Doxorubicin question

Michael Woodhouse — Thu, 09 Dec 2010 22:15:55 GMT

What about a fixed volume in a burette? Save risk of fluid overload and can run open?

Never done it, just a thought.