mammary carcinoma

RE: mammary carcinoma

Lucy Fleming — Tue, 28 Aug 2018 21:33:09 GMT

Apologies, forgot to come back and update. Histopathology of the masses was inconclusive due to very poor cellular differentiation, eventually immunohistochemistry confirmed them as a high grade soft tissue sarcoma. Unrelated to the original mammary carcinoma (had a niggling suspicion that would turn out to be the case as the cytology and behaviour didn't fit).

Didn't follow up any further on testosterone as it wasn't relevant to the case as it was presenting to us.

RE: mammary carcinoma

Anthony Todd — Sat, 25 Aug 2018 16:03:09 GMT

[quote user="robloxley"]Fractional distillation of vetsurgeon.org?[/quote]

[got it when I read it again.....] not here mate....

Try here though if back on thread:

www.netdoctor.co.uk/medicines/a7464/restandol-testocaps-testosterone/ and other searches.

I would expect mammary tumours to halve in size in 2 weeks or so, IMHE.

RE: mammary carcinoma

Rob Loxley — Thu, 05 Jul 2018 15:25:52 GMT

[quote user="Lucy Fleming"]no idea where I would procure testosterone![/quote]

Fractional distillation of vetsurgeon.org?!

RE: mammary carcinoma

Rob Davis — Thu, 05 Jul 2018 14:26:16 GMT

[quote user="Lucy Fleming"]though I have no idea where I would procure testosterone[/quote]

Does durateston still exist?

RE: mammary carcinoma

Anthony Todd — Thu, 05 Jul 2018 09:18:21 GMT

[quote user="Lucy Fleming"] I have no idea where I would procure testosterone! [/quote]

Search "m-testosterone tabs" or "Sustenon" [both legal and dodgy sources around....]

RE: mammary carcinoma

Marie Kubiak — Wed, 04 Jul 2018 21:49:43 GMT

[quote user="Lucy Fleming"] I have no idea where I would procure testosterone! [/quote]

No input on the case I'm afraid but I have used our local hospital pharmacy for sourcing testosterone.

Marie

RE: mammary carcinoma

Lucy Fleming — Wed, 04 Jul 2018 18:49:35 GMT

[quote user="Anthony Todd"]

Not trying to be argumentative, but what I and others, did was give testosterone to bitches with mammary tumours which reduced their size by 50ish% in a week or so, and made them so much more "dense" and "circumscribed" making prompt surgery easier and the margins much more definite.

With multiple metastases [er, not more than, say, ten] I'd just remove them all, no biopsy, but an obviously guarded prognosis.

You may be surprised at how effective early removal is, even done more than twice.

[/quote]

Not argumentative at all - though I have no idea where I would procure testosterone! For clarity, there wasn't an obvious problem with the margins on the original mass removal, it appeared to be completely excised with >3mm normal tissue. Luckily it was one of those solid, dense ones rather than the soft ones with indistinct edges.

I'm not sure removing all the new masses will be practical, unfortunately. She's covered in them pretty much stem to stern, mainly along her back. They vary in size from about 1/2 a cm and raised to very subtle thickenings of the skin. The lumps themselves aren't painful, so unless I can get them all (and I suspect I couldn't) I might cause her more harm than good by trying. Plan was to harvest a few for diagnostic purposes as, to be honest I'm suspicious (and the specialist I chatted to agrees) that this behaviour isn't consistent with the histological findings of the original mass. Poor dog might in fact have a completely different primary tumour somewhere.

RE: mammary carcinoma

Anthony Todd — Wed, 04 Jul 2018 13:53:09 GMT

[quote user="Lucy Fleming"]Bumping this old thread[/quote]

With multiple metastases [er, not more than, say, ten] I'd just remove them all, no biopsy, but an obviously guarded prognosis.

You may be surprised at how effective early removal is, even done more than twice.

RE: mammary carcinoma

Lucy Fleming — Wed, 04 Jul 2018 13:00:43 GMT

Bumping this old thread as I have a similar case at the moment, and was wondering if any miraculous new options available!

8 1/2 year old springer spaniel, had a mammary carcinoma removed in Oct 2017 (along with a benign mixed mammary tumour and a lipoma) - presented recently with multiple small firm nodules in the skin, FNA suggestive of malignant epithelial neoplasia and suspected to be metastases of the original mammary mass. I plan to (if the owner wishes) biopsy a few of the masses (she has upwards of a dozen) to find out for sure what they are, but wondering what experience others have of these?

Re: mammary carcinoma

Mark Holmes — Fri, 30 Jul 2010 13:29:53 GMT

I had a dog with mammery carcinoma and a chest full of golf balls go for ages (>1 year) on meloxicam alone, did great. Not that the tumour changed or the golf balls reduced, they just stopped getting bigger. Statistically insignificant sample size n=1 but I would do it again.

Not every carinoma responds to meloxicam they need cox 2 receptors I think but I have found it can work great in cases of carcinoma anywhere, anal gland/sac (take your pick) carcinomas and small intestinal adenocarcinoma too. Resected a small intestinal adenocarcinoma which had concurrent adenocarcinomatosis of the omentum and peritoneum and eventually euthanased it 12 months later. Went problem free until about 2d before the very end.

Re: mammary carcinoma

Martin Atkinson — Sat, 24 Jul 2010 10:46:06 GMT

Although its not licenced for this and will not help the primary tumour there's a possibility Mastinib (Masivet) may reduce the advancement of metastatic disease with minimal side effects, however it is expensive. Its made by AB Science so you could contact them for further information or Gerry Poulton at NDSR in the UK.

Re: mammary carcinoma

Martin Jones — Fri, 23 Jul 2010 21:11:06 GMT

I would talk to a couple of peeps - Cambridge vet school are excellent for neoplasia advice, and often can come up with lower stress chemo protocols that won't be too alarming. I'm of an age that thinks steroids are heaven sent for these kinds of cases - along with some tramadol. My general experience of axillary mets is pain and discomfort and the combination helps patient and owner alike.

Re: mammary carcinoma

Charlie Georgetti — Fri, 23 Jul 2010 20:43:47 GMT

Hey, thanks for the advice. Chest rads are clear at present, but I agree, prob something nasty somewhere, and still no sign of the primary. So just going for minimal palliative care.

Re: mammary carcinoma

Edward Jones — Fri, 23 Jul 2010 13:43:07 GMT

Sounds like a case for prednisolone until quality of life is insufficient to me.

Superficially (i.e. without knowing the precise details), I don't think I'd advise further surgery or chemo even if the owner was up for it - it sounds pretty aggressive to me. Even if the chest xrays are clear I think I'd bet my house on there being mets in there somewhere.

Re: mammary carcinoma

Richard Carter — Fri, 23 Jul 2010 13:10:43 GMT

Certainly helps in highly malignant mammary tumours where inflammation is the main pathology seen. Will interfere with the healing of your surgical wounds though. Meloxicam is supposed to have sl more direct effect on the tumour itself (obviously not used together!)