Piroxicam use

Re: Piroxicam use

Trevor Turner — Sat, 03 Jul 2010 20:40:16 GMT

Similarly, I had a 10kg dog whose dose was 3mg (for oral SCC), and so I just gave him 5mg (half a 10mg I think). He went on for a good 18months with no problems, apart from the tumour.

As far as overdosing goes, at one point my boss saw him for a "flare up" and increased the dose to 30mg! It was 3m before I saw the dog and lowered the dose. Again, no side effects.

Re: Piroxicam use

Rob Loxley — Fri, 25 Jun 2010 19:38:33 GMT

[quote user="Rebecca Benge"]What are the risks of overdosing with piroxicam, in terms of gastric ulceration etc?[/quote]

J Vet Intern Med. 1994 Jul-Aug;8(4):273-8. Knapp DW et al. Piroxicam therapy in 34 dogs with transitional cell carcinoma of the urinary bladder:
34 dogs on piroxicam; "toxicity consisted of gastrointestinal irritation in 6 dogs and renal papillary necrosis (detected at necropsy) in 2 dogs". Not great!

On a separate note, have you talked to an oncologist, particularly about combination treatment e.g. mitoxantrone?
(HENRY C. J. et al; (2003); Clinical evaluation of mitoxantrone and piroxicam in a canine
model of human invasive urinary bladder carcinoma. Clinical Cancer
Research 9, 906-911.)

Re: Piroxicam use

Michael Woodhouse — Fri, 25 Jun 2010 16:43:55 GMT

RVC use meloxicam and say it seems as good.

Re: Piroxicam use

Derek Copeland — Fri, 25 Jun 2010 15:50:38 GMT

Many moons ago we used a lot of piroxicam for DJD/OA . Like many NSAIDs it is not without its side effects but I would be quite happy to use 10mg in a 20kg dog . If you want to be clinically pure i am sure you could give gut protectants(cytotec is very useful) and monitor kidney function but the dog has a tumour go for it

Re: Piroxicam use

nikki — Fri, 25 Jun 2010 15:14:03 GMT

yes, i have always used meloxicam instead. it does seem to have similar results anecdotally.

Re: Piroxicam use

Kirsten Simpson — Fri, 25 Jun 2010 13:43:38 GMT

You could use Meloxicam instead? If I recall correctly it's very similar and some places use it instead?