Onsior ( Robenacoxib)

Re: Onsior ( Robenacoxib)

Julian Earl — Fri, 04 Dec 2009 18:59:45 GMT

We have used Trocoxil on a few cases and not had any problems. The effects seem to be most apparent by about the second or third tablet rather than immediately and we have had no complications so far. I suspect - though have no hard evidence - that the aspect that is most beneficial is this constant presence within the system that stops the yo-yoing effect of analgesia that may be apparent with daily dosing.

And no, I am not paid or sponsored by Pfizer.

Re: Onsior ( Robenacoxib)

toby travis — Fri, 27 Nov 2009 18:30:23 GMT

As far as I could see, there was no hard evidence in the trials to suggest that Onsior was any safer than metacam and nothing to say it was any better, excpet for the fact that it is a COX-2 NSAID.

Anecdotally, people seem to much prefer being on COX-2 selective NSAIDs (in spite of the increased heart problems in people) compared to the more traditional ones, so I do wonder whether the same is true for our patients. I do use Previcox, often as an alternative to metacam and sometimes it is better, so far it has been no worse in any cases, but it is a little more expensive - all the meloxicam producing companies are really touting for business!

Re: Onsior ( Robenacoxib)

Rob Reid — Thu, 26 Nov 2009 17:19:56 GMT

I have used Onsior in a couple of arthritic dogs, one was a new patient, other one is an ongoing case. I have not been impressed in either case and resorted back to an 'older and less safe' NSAID with better results.

I have however had some good responses to Previcox....

Re: Onsior ( Robenacoxib)

ms1083 — Wed, 25 Nov 2009 13:05:10 GMT

You would have of thought that drug companies would actually do research about whether there is a need for a new drug and whether anyone plans to use it before spening money making & licensing it!

I like onsior but never plan to use the once a month one, can't even remember its name despite being talked to for ages by a rep (but she had food!).

Re: Onsior ( Robenacoxib)

Hannah Wynne Richards — Wed, 25 Nov 2009 09:16:48 GMT

Same opinion as everyone else Never used it, scared to use it

Wynne

Re: Onsior ( Robenacoxib)

listhestar — Mon, 23 Nov 2009 18:33:15 GMT

Lisa[quote user="Hanna Bennett"]

yup, it scares me - like you say if the dog has any other problems during the month, or if they develop side effects two weeks in - how do you take away the drug!

[/quote]

Glad it's not just me- a month long acting prep just takes away some control. Say you have an older dog on the drug who then gets stung on the throat and enters resp problems and needs steroid etc. I'm not sure what you can do apart from give gastroprotectants and warn the owner?

lisa

Re: Onsior ( Robenacoxib)

Hanna Bennett — Sun, 22 Nov 2009 15:17:55 GMT

yup, it scares me - like you say if the dog has any other problems during the month, or if they develop side effects two weeks in - how do you take away the drug!

Re: Onsior ( Robenacoxib)

Utlendigur — Sun, 22 Nov 2009 14:37:26 GMT

My feelings exactly. The "pros" we were told were ease of dosing (but I've never come across an animal that won't take one of the many formulations of nsaids - in fact with Rimadyl the problem is often that it is too palatable) and that it prevents central sensitisation to pain (but surely the same can be achieved with sid or bid dosing of other nsaids for an adequate time period).

I'd also be worried about the duration of action with no opportunity to stop dosing if problems. Ok we could do bloods and urine SG on all potential cases but what happens if the dog for example develops severe GE or has to undergo surgery and becomes hypovolaemic during the month it is on treatment.

I really cannot see any benefit above the many nsaids available that would make it worth the risk, and it seems to me that the drug company have just decided to invent a niche for it, which doesn't really exist

Re: Onsior ( Robenacoxib)

Rob Loxley — Sun, 22 Nov 2009 11:27:21 GMT

My current feeling is that the difference in an individual animal's response to different NSAIDs is greater than the out-and-out superiority/inferiority of one drug over another, if that makes sense.

[quote user="Matthew Scotter"]Slight off on a tangent but what about "Trocoxil" mavacoxib?[/quote]

I spent far too long being talked at by the rep (why do reps assume you are stupid, and haven't read their product SPC and licensing data summaries already?) without the rep being able to explain what the problem was that the new drug solved.

Re: Onsior ( Robenacoxib)

ms1083 — Sun, 22 Nov 2009 10:02:50 GMT

Slight off on a tangent but what about "Trocoxil" mavacoxib?

I failed to be impressed by our rep but she convinved the partners to get some in a few months ago - so far no one has used any!!

It is supposed to be a once a month NSAID for dogs with OA. My concerns are:

If the dog spits a tablet down the drain it is very expensive!

THe rep says it is not COX 2 selective, so seems its only advantage is once monthly dosing.

Have to have a month off after a few months, I imagine as 1 dose actually lasts longer than a month this is to reduce the levels to ensure the dose does not mount up to dangerous levels. Rep didn't understand this and said that is not why.

Personally, when starting does on NSAID for OA, I tend to give a trial course for a few weeks to see if there is any improvment, if not then I try a different NSAID. If a dog is already stable on a NSAID then I would not change. Not sure how to select which cases to use this drug on.

However, if this were safe & licesed for cats it may well be much more useful. Any one used it, or have any views?

Re: Onsior ( Robenacoxib)

Richard Carter — Sat, 21 Nov 2009 19:12:53 GMT

Will be watching from the corner having in the 1990's swallowed hook line and sinker the very powerful propoganda put out by the company producing a favourite NSAID about how safe it was in peri-operative pain relief. The end result - ARF in some very routine cat dentals. Similarly notice the current NSAID licenced for arthritis treatment in cats has now included a rather large and broad disclaimer about using in elderly animals etc.

Re: Onsior ( Robenacoxib)

Hanna Bennett — Fri, 13 Nov 2009 16:55:42 GMT

I like the idea of the injection and tablet combination being licensed in cats - we struggle with metacam - not knowing when you can start something on oral formulation after the injection makes it difficult when you have say a broken cat.

However, being the cynical cow i am, I'd love to hear someone justify it being so much better than the usual drugs before changing my routine. My theory with nsaids has always been use with care anyway, but you'll always have some that react to one, and changing them to any other one seems to solve the problem. If the Onsior truly is tissue specific i guess this possibly reduces the risk of side effects, but then our question was what happens in chronic conditions where the active inflammation is not there to attract the drug?