https://www.vetsurgeon.org/f/clinical-questions/31277/human-hrt-and-canine-hyperaestrogenism Young male neutered pug. Has hypertrophic and hyperkeratinised (very dangly) nipples. He does sit on his owners knees. She washes her hands after applying topical medications but could he be exposed through clothing from sitting on her knee?? en-USTelligent Community 10https://www.vetsurgeon.org/thread/248115?ContentTypeID=1Tue, 09 Dec 2025 20:34:29 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:b8f4c954-d984-4871-bf0d-e05fccd42ce2David Scarff<p>Yes, I agree that the HRT could be responsible if no pruritus.&nbsp;</p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/248113?ContentTypeID=1Tue, 09 Dec 2025 20:13:22 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:13bb2ecc-7f94-4ebe-a587-044e6bc0556fSara Ramsey<p>I did wonder if he was pruritic and rubbing his belly on the ground but owner says not.</p> <p>She washes her hands but supposedly sorting on her knee could expose him to the HRT (I posted on a FB group and some have seen similar)</p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/248100?ContentTypeID=1Mon, 08 Dec 2025 09:46:46 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:c16b6f93-786c-47d4-bb5a-d9ae0f396a0eDavid Scarff<p>Hypertrophic and hyperkeratotic nipples can also be secondary to self trauma, even if this is mild. Are all of the nipples affected?&nbsp;</p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/248095?ContentTypeID=1Sun, 07 Dec 2025 10:46:49 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:747237f4-ef61-4e54-876f-4c050b3c3349Nicola Robinson<p>Although it sounds as though it could be related, it may be worth checking the history.&nbsp; If the pug has not had direct access to the HRT then oestrogen will not be the cause.&nbsp; There will not be exposure through clothing - it needs to be direct.</p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/248076?ContentTypeID=1Tue, 02 Dec 2025 18:01:46 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:c0b95ed2-e2bc-4664-a397-0df5f3231289Dinu Catilina<p>Yes, very likely to be the oestrogen. Best thing is to avoid contact while using the gel, even small amounts are sufficient to affect a small dog.&nbsp;</p><div style="clear:both;"></div>