https://www.vetsurgeon.org/f/clinical-questions/30699/has-anyone-seen-incontinence-develop-with-solensia-in-cats I have posted on the similar Librela thread, but I have a case I am suspicious may be incontinent as a side effect of Solensia, seems to have been reported in dogs on Librela Anyone else seen this? en-USTelligent Community 10https://www.vetsurgeon.org/thread/241789?ContentTypeID=1Sun, 25 Jun 2023 13:04:38 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:7d93148b-ec52-4862-bfd2-0f0772530edbRichard Carter<p><div class="fm-flexbox"> <div class="fm-citation"> <div class="citation-default"> <div class="part1"><span><a target='_blank' href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326241/">Vet Rec.</a></span> 2019 Jan 5; 184(1): 23.</div> <div class="part2"><span class="fm-vol-iss-date">Published online 2018 Oct 27. </span><span class="doi"><span>doi:&nbsp;</span><a href="https://doi.org/10.1136%2Fvr.104590" rel="noopener noreferrer" target="_blank">10.1136/vr.104590</a></span></div> </div> </div> <div class="fm-ids"> <div class="fm-citation-pmcid"><span class="fm-citation-ids-label">PMCID: </span><span>PMC6326241</span></div> <div class="fm-citation-pmid">PMID: <a target='_blank' href="https://pubmed.ncbi.nlm.nih.gov/30368458">30368458</a></div> </div> </div> <h1 class="content-title">Anti-nerve growth factor monoclonal antibodies for the control of pain in dogs and cats</h1> <div class="half_rhythm"> <div class="contrib-group fm-author"><a target='_blank' class="affpopup" id="author-56257702" href="https://pubmed.ncbi.nlm.nih.gov/?term=Enomoto%20M%5BAuthor%5D">Masataka Enomoto</a>,¹ <a target='_blank' class="affpopup" id="author-56277262" href="https://pubmed.ncbi.nlm.nih.gov/?term=Mantyh%20PW%5BAuthor%5D">Patrick W Mantyh</a>,²<a target='_blank' class="affpopup" id="author-35841956" href="https://pubmed.ncbi.nlm.nih.gov/?term=Murrell%20J%5BAuthor%5D">Joanna Murrell</a>,³ <a target='_blank' class="affpopup" id="author-25644766" href="https://pubmed.ncbi.nlm.nih.gov/?term=Innes%20JF%5BAuthor%5D">John F Innes</a>,⁴ and <a target='_blank' class="affpopup" id="author-36231960" href="https://pubmed.ncbi.nlm.nih.gov/?term=Lascelles%20BD%5BAuthor%5D">B Duncan X Lascelles</a>^1,^5,^6,⁷</div> <div class="contrib-group fm-author"></div> <div class="contrib-group fm-author"><span style="font-size:xx-small;">&hellip;&hellip;</span><span>In the PNS, in addition to the role in the regulation of neurotransmitters and neuropeptides synthesis, NGF has the protective action on the survival of degenerating peripheral nerve cells.</span><a target='_blank' class=" bibr popnode" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326241/#R39">39</a><span>Deprivation of NGF can lead to damage of neurons,</span></div> </div></p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/241788?ContentTypeID=1Sun, 25 Jun 2023 12:25:48 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:49cd2ccb-dfb5-4867-ac72-c3c5951f6f4aRichard Carter<p>Been trying to find the article about anti NGF but so far been unsuccessful- think it was a bsava or vet record but one of the comments that is known is that cholinergic nerves need NGF so the parasympathetic system might be adversely affected&nbsp;</p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/241784?ContentTypeID=1Sun, 25 Jun 2023 11:05:20 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:b0c00bd6-c68b-4a96-94a5-125d74bea08bAlasdair Hotston Moore<p>I have not heard of this in cats. &nbsp;But incontinence is a rare sign in cats so I guess it might be more than a conicidence</p><div style="clear:both;"></div>