Feline Allergic skin disease medications

RE: Feline Allergic skin disease medications

Delia Richter — Fri, 27 Jan 2023 11:31:42 GMT

Sorry for delay!

RE: Feline Allergic skin disease medications

Kate Richardson — Thu, 12 Jan 2023 09:08:40 GMT

Update- saw her this morning- all healed and hair fully regrown! Hasn't had Atopica since before Xmas as people looking after her couldn't administer it, so solely has depomedrone on board. Thus I suspect compliance was the issue!! Is eating z/d happily now, so plan to transition to 100% z/d, cont depomedrone for another 3 months, then if all still good, will stop the steroids and see what happens with diet alone.....

RE: Feline Allergic skin disease medications

Kate Richardson — Tue, 10 Jan 2023 16:22:51 GMT

Thanks everyone for your input, already tried some of the suggestions, but gabapentin a good shout, and alternative corticosteroids, Pred at 3mg/kg daily had some effect but not enough. Could go higher if all else fails! Won't hurt to give Credelio.

Delia Richter do you have a copy of the Zoetis statement or can you summarise?

RE: Feline Allergic skin disease medications

Delia Richter — Fri, 06 Jan 2023 12:37:20 GMT

Heya, what dose of prednisolone were you using? These guys sometimes need 2 - 4 mg/kg sid.

Also dexamethasone as an alternative, 0.5mg/cat sid. You can use the injectable dexamethasone (like colvasone) orally, and it has very little taste.

Even if you think the flea control is good, I would still give an oral isoxazoline like credelio. I would never consider FAD to be ruled out without this.

Apoquel in cats is now a last resort - there was a recent statement about issues with the safety made by Zoetis at the ESVD conference in September.

Cheers,

Delia

(Happy Skin Vet)

RE: Feline Allergic skin disease medications

Beats — Tue, 03 Jan 2023 20:57:56 GMT

Thanks Richard - that's really helpful!

I should have just checked the datasheet before random Googling!

RE: Feline Allergic skin disease medications

Richard Carter — Tue, 03 Jan 2023 03:19:52 GMT

No it was used a lot- basically injectable ovarid. The dose per cat was 1.5 ml and would last for months.

Good results on all the eosinophilic complexes, general skin problems from allergy

But it can cause obesity and DM so ideally on a low calorie diet and owner fully aware but in cases of extreme discomfort and self mutilation works with fairly reliable results and means owner compliance less of an issue

from NOAH

1 Clinical particulars

Feline miliary dermatitis (miliary eczema): treatment and prevention. ... feline miliary dermatitis - 33-50 mg/kg, or 1.5 ml for the average 3 kg cat. ... Treatment and prevention of feline miliary dermatitis: A single injection is often sufficient but a second dose may be given 14 days later if the clinical response

Why does it work? Part of the steroid complex, perhaps progesterone / other sex hormones deficiency is causing a defect in the immune system?

Or is it chronic stress leads to adrenal ineffective leads to disease or is it an anabolic so promotes healthy skin?

I’m sure someone clever will come along!

RE: Feline Allergic skin disease medications

Beats — Mon, 02 Jan 2023 21:06:55 GMT

I can find very little on use of delvosterone as an anti-pruritic (possibly because google returns me a lot of stuff on progestogen hypersensitivity causing pruritus in women when I search). I found only one cryptic mention here: https://www.sciencedirect.com/science/article/abs/pii/S019556169550138X but behind a firewall and not sure what it says.

Is this personal experience that delvosterone works as an anti-pruritic in cats, or is there more information out there that I'm failing to find? I've not known about this idea before, so interested to find out more.

RE: Feline Allergic skin disease medications

Richard Carter — Mon, 02 Jan 2023 18:11:12 GMT

Quite good at obesity and DM but very good at getting cats to stop chewing holes in themselves

RE: Feline Allergic skin disease medications

Beats — Mon, 02 Jan 2023 17:22:41 GMT

does delvosterone do anything useful except stop estrous in ferrets?

RE: Feline Allergic skin disease medications

Glenn Hodgson — Mon, 02 Jan 2023 09:39:03 GMT

Put away other food so the cat eats it's hypo diet?

Also, more steroids? Double depo dose and give every 3 weeks. Better to have steroids than scratch it's neck open.

I was also thinking Ovarid... Could we ask Summit to put this on their tomake list? They were looking for good ideas

RE: Feline Allergic skin disease medications

Richard Carter — Mon, 02 Jan 2023 09:14:15 GMT

Where is ovarid when you need it

If this cat is really self mutilating very badly, could always do a delvosterone until the skin has healed to get a ‘clean’ slate?

RE: Feline Allergic skin disease medications

Allison Gleadhill — Sun, 01 Jan 2023 22:35:22 GMT

Might be tempted to try Gabapentin added into steroids & antibiotics

RE: Feline Allergic skin disease medications

Michael Woodhouse — Sun, 01 Jan 2023 21:28:35 GMT

[quote userid="6386" url="~/001/veterinary-clinical/small-animal/dermatology/f/discussions/30527/feline-allergic-skin-disease-medications/240336#240336"]have given depomedrone over Christmas [/quote]

That was all I had to contribute. Find it well tolerated in cats and anecdotally much more effective than preds.

RE: Feline Allergic skin disease medications

Izbat — Sun, 01 Jan 2023 12:06:26 GMT

Summit make a chicken flavoured prednisolone liquid medication that I have found really useful for cats where compliance is an issue

RE: Feline Allergic skin disease medications

bob lehner — Sun, 01 Jan 2023 10:26:16 GMT

[quote userid="6386" url="~/001/veterinary-clinical/small-animal/dermatology/f/discussions/30527/feline-allergic-skin-disease-medications"]Any other suggestions[/quote]

These can be very stubborn to clear.

On occasion I seem to have had more success with topical application of steroid/antibiotic creams, rather than systemic. No proof - just my observation. Can apply with a cotton bud and rub in well.

RE: Feline Allergic skin disease medications

Kate Richardson — Fri, 30 Dec 2022 12:10:57 GMT

[quote userid="12930" url="~/001/veterinary-clinical/small-animal/dermatology/f/discussions/30527/feline-allergic-skin-disease-medications/240337#240337"]

Cutting back nails super short (effectively cut right off until bleeds) under sedation also.

I've never done it (never had the need), but as an eccentric thought I do wonder if some of these ridiculous cases of self-induced head and neck pruritus in cats would be much happier with a declaw?

[/quote]

Both unethical!!!

RE: Feline Allergic skin disease medications

Kate Richardson — Fri, 30 Dec 2022 12:07:58 GMT

Biopsies last year didn't show any demodex or infection, but I guess I could repeat biopsies and skin scrapes to be certain. I'm suspicious of food allergy given location but would still have thought it would respond to pred or cyclosporin even without full compliance with diet

RE: Feline Allergic skin disease medications

Richard Carter — Fri, 30 Dec 2022 12:07:29 GMT

Other things I’ve found- doesn’t always have to be hypoallergenic- sometimes just taking off all pouch or wet food, no dreamies is enough. My go to dry food is purina sensitive

And then the usual checking no air fresheners, plants or other fibrous material being used to rub against

RE: Feline Allergic skin disease medications

Beats — Fri, 30 Dec 2022 11:59:10 GMT

apoquel 1mg/kg q12 hours for a month as a trial. 16mg tablets can be quartered. Then reduce to once daily. I've done alongside steroids on occasions. Good success in cases like you describe in my limited experience.

Pyoderma common enough in cats and culture and apporpriate antibitoics may be good idea too (although I find if control itch often resolves anyway).

Cutting back nails super short (effectively cut right off until bleeds) under sedation also.

I've never done it (never had the need), but as an eccentric thought I do wonder if some of these ridiculous cases of self-induced head and neck pruritus in cats would be much happier with a declaw?

COuld consider testing for viruses and other more unusual things.

Credelio tablets monthly to cover demodex gatoi as well as fleas.

BIG doses of depo-medrone another option.

RE: Feline Allergic skin disease medications

Kate Richardson — Fri, 30 Dec 2022 11:55:38 GMT

Flea control good, could try alternative antibiotic but it doesn't look infected.

Have had a few cats that don't respond to pred as well as they should, but as I said, compliance isn't brilliant (cat won't eat food with meds in and not easy to directly medicate)- have given depomedrone over Christmas so will see if that improves things re compliance.

Have tried topical treatments, minimal effect.

RE: Feline Allergic skin disease medications

Richard Carter — Fri, 30 Dec 2022 11:45:00 GMT

Current flea rx? Wondering if a spot on dermatitis or something else topical because if truly allergic in origin, really should have had good response to preds or /and cyclosporine.

Efa and good skin abs like clindamycin or doxycycline any effect? Opportunistic demodex?