https://www.vetsurgeon.org/f/clinical-questions/30341/anal-furunculosis I&#39;m treating a 6 year old German Shepherd with anal furunculosis. Been on prednisolone for a long time but hasn&#39;t done anything, and was tried with azothioprine , tacrolimus topical, metronidazole in combination with the pred also. A surgery has alsoen-USTelligent Community 10https://www.vetsurgeon.org/thread/238738?ContentTypeID=1Thu, 18 Aug 2022 08:31:16 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:660dd2d8-36c8-41de-a961-b1a683dca433David Scarff<p>Sometimes once the area has reduced and the pain is less then topical tacrolimus can be substituted. This is rarely a &#39;curable&#39; disease however.</p> <p></p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/238734?ContentTypeID=1Thu, 18 Aug 2022 06:09:28 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:3ade747c-2b9c-43c7-b100-40f0ef636fb8Nina de Goede<p>Thanks . We have actually proceeded with cyclosporin and ketoconazole and so far there has been a reduction in furunculoses size by approx 2/3rds</p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/238708?ContentTypeID=1Tue, 16 Aug 2022 14:12:38 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:1526f986-9652-4039-9c22-14795a530002David Scarff<p>I&#39;ve not used Apoquel personally, although as it is helpful in some of the immune mediated conditions (pinnal vascultis etc) it might be helpful. Some workers use concurrent ketoconazole to reduce ciclosporin dosages, although this is off label and somewhat unpredicatble. I cannot see the value of cytopoint. Ciclosporine would be the treatment of choice, although I have had success with 1% tacrolimus. (0.03% is not effective in my ecperience).</p><div style="clear:both;"></div>