Leishmania and meglumine antimoniate (Glucantime)

RE: Leishmania and meglumine antimoniate (Glucantime)

Richard Huddart — Sun, 15 May 2022 17:17:22 GMT

We show people how to inject. Merlinvet very speedy with delivery of Glucantime. Generally we give only once daily for the first week , to make sure no side effects. Then increase to twice daily for 30 days. Use 25 g needle to inject.

As well as allopurinol.

I drew up weekly sets of filled syringes for the last client -as I think the glass vials can break sometimes.(and it was 14 y.o. daughter of a policeman doing the injecting …….she wants to be a vet.)

RE: Leishmania and meglumine antimoniate (Glucantime)

Beats — Fri, 13 May 2022 19:31:52 GMT

25 mg/kg artesunate daily for 6 days, orally might be an attractive option to consider also.

Potential of Artesunate in the treatment of visceral leishmaniasis in dogs naturally infected by Leishmania infantum: Efficacy evidence from a randomized field trial | PLOS Neglected Tropical Diseases

RE: Leishmania and meglumine antimoniate (Glucantime)

Silvia Maldonado — Fri, 13 May 2022 08:44:33 GMT

Hi, Clive,

Each dog respond very, very different. In general, using milteforan once a year for 2 or 3 years or using glucantime very 3-6 months works well for most of them, but you will come across the challenging one who does not seem to respond to anything. Other dogs may carry leishmania with minimal or no symptoms at all, and you only know it after a routine snap test (obviously, in Mediterranean countries)

Some dogs don't cope very well with glucantime. In general, milteforan has better results. However, it seems that glucantime works better after using 1 or 2 courses of milteforan.

Injection can be a bit painful on site, and in large dogs you need to split it in 5ml/site maximum. You will see better results if you are also using allopurinol at the same time, which is quite cheap and oral.

Good luck!

RE: Leishmania and meglumine antimoniate (Glucantime)

Clive Ansell — Fri, 13 May 2022 06:35:51 GMT

Thanks Beats. Merlinvet are being very helpful.

The dog has had already had 2 coures of Miltefosine, with little success. owners keen to try Glucantime.

RE: Leishmania and meglumine antimoniate (Glucantime)

Beats — Mon, 09 May 2022 20:24:03 GMT

merlinvet

They also do the miltefosine which can be given orally - bit more convenient.

https://www.leishvet.org/fact-sheet/therapy/