https://www.vetsurgeon.org/f/clinical-questions/30255/misoprostol-and-nsaid-toxicity we have had a spate of meloxicam overdoses and ibuprofen ingestions. we stopped stocking misoprostol as not much evidence and adverse effects can be problematic. is anyone routinely using it? en-USTelligent Community 10https://www.vetsurgeon.org/thread/236798?ContentTypeID=1Tue, 05 Apr 2022 12:26:49 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:711fe3a1-0714-4ca4-b04d-f3834bc31ecaJoyce Whitehead<p>I have used it. My own dog (of course) stole an almost full large bottle of metacam off a table overnight (not out away after use annoyingly) and ate probably a lot of it. He is a 9.5kg Border Terrier. &nbsp;He had terrible melaena and vomited for about 24 hours, had IV fluids, and initially omeprazole, but BI recommended misoprostol. We already stock it because we do horse work, so I started that too. It took about (a very very long feeling) 10 days for him to start eating properly, he became very suspicious of anything I gave him. Miraculously absolutely no change in renal or hepatic values during or after which I consider to be a confidence boost in using metacam in some older patients.&nbsp;</p><div style="clear:both;"></div>