Solensia

RE: Solensia

Joyce Whitehead — Sat, 10 Jul 2021 13:47:48 GMT

Great to hear that Richard. We haven’t had any suitable cat patients yet but have used quite a bit of Librela. I gave a first dose to an elderly Labrador last night, already on carprofen and gabapentin. The owner rang this morning just to let me know he had a new dog today, bouncing around trying to play ball. Such lovely news.

RE: Solensia

Richard Carter — Sat, 10 Jul 2021 09:53:08 GMT

One month in and said cat now going outdoors and hunting ( unsuccessfully) baby bunnies on the lawn so will definitely be repeating

RE: Solensia

Virginia Campbell — Thu, 08 Jul 2021 23:40:59 GMT

[quote userid="6550" url="~/001/veterinary-clinical/small-animal/f/misc-case-discussions/29891/solensia/230900#230900"]Why on earth do they keep using these stupid made up names that are meaningless? Cerenia, Convenia, Lebrela, Solensia.[/quote]

Cos it sounds a bit Latin. Which sounds clever and sciencey. (Remember the Post Office launching "Consignia"? It was considered hilariously w**ky.

RE: Solensia

Andreas Ege — Thu, 01 Jul 2021 08:02:35 GMT

[quote userid="5904" url="~/001/veterinary-clinical/small-animal/f/misc-case-discussions/29891/solensia/230999#230999"]That's unless the occasional owner or vet not has the wit to stop a drug at the first sign of any possible adverse reaction??[/quote]

Ideally. Don't know about your clientele, but I get clients who do or don't stop medications without consulting me first.

[quote userid="5904" url="~/001/veterinary-clinical/small-animal/f/misc-case-discussions/29891/solensia/230999#230999"]Are there any/many drugs that do not have at least some adverse effects sometimes?[/quote]

Not if they have an effect. If somebody claims a given medication doesn't have side effects, my first thought always is, does it have a wanted effect? But some meds will have more or more severe adverse effects than others. In case of solensia we have a relatively good understanding of the adverse effects of the alternatives, but little about the mid to long term effects of solensia. To repeat myself, I'm not saying it shouldn't be used. Only that, in my opinion, it shouldn't be the first option, for the reasons given above.

Though I admit, I don't get your point with above statement. That other medications will/ might have adverse effects can hardly be an argument to ignore potential adverse effects of one specific med.

[quote userid="5904" url="~/001/veterinary-clinical/small-animal/f/misc-case-discussions/29891/solensia/230999#230999"]Are there any drugs whose adverse effects are not reversed if the drug is not stopped quickly....?[/quote]

Spontanously cats and injection related fibrosarcoma would come to mind... ;-)

In humans it is accepted that pancreatitis can be a rare adverse event from NSAIDs. Not quickly or easily resolved and going along with a strong negative effect on quality of life, at least short term. I'm sure there are others, both in human and veterinary medicine.

RE: Solensia

Anthony Todd — Tue, 29 Jun 2021 17:09:30 GMT

[quote userid="13609" url="~/001/veterinary-clinical/small-animal/f/misc-case-discussions/29891/solensia/230996#230996"]Unwanted effects or adverse reactions can impact on quality of life as well.[/quote]

That's unless the occasional owner or vet not has the wit to stop a drug at the first sign of any possible adverse reaction??

[and also has the wit to try a few days again later to see if it happens again.]

Are there any drugs whose adverse effects are not reversed if the drug is not stopped quickly....?

Are there any/many drugs that do not have at least some adverse effects sometimes?

RE: Solensia

Andreas Ege — Mon, 28 Jun 2021 11:25:48 GMT

Can fully agree with that and never said you shouldn't use it.

Nevertheless, at the moment I wouldn't use it as a first line treatment between my long-term concerns and a reasonably realistic chance it might not be better than placebo long-term. After all, that statement is from the manufacturers datasheet and again there is a realistic chance their data is more positive than what we'll see in the field. Unwanted effects or adverse reactions can impact on quality of life as well.

RE: Solensia

Neil Wheadon — Sat, 26 Jun 2021 08:45:30 GMT

[quote userid="13609" url="~/001/veterinary-clinical/small-animal/f/misc-case-discussions/29891/solensia/230962#230962"]What I find irritating with solensia is the following statement in the datasheet: "Statistically significant difference (p<0.05) compared to placebo-treatment was demonstrated after the first and second treatment, but not after the third treatment."[/quote]

I'm going to speak as an owner and also a view that I know is shared by other vets. I want my cat to be comfortable, I'm not concerned about longevity, it's all about quality of life.

We have a 14 year old cat that was simply not enjoying life as he did before. Custard has a finite life as we all do. If I can make his life more comfortable for 6 months and he dies a little quicker then so be it. I often quote the Australian study on Metacam where cats in renal failure live longer on a 1/4 dose of metacam because they feel better, eat better. Life's for living and that includes our feline friends

Neil

RE: Solensia

Richard Carter — Sat, 26 Jun 2021 08:12:20 GMT

One week post solensia in a 13 year old that has very limited range of movement all joints, spine etc. Even under ga, cannot free up but she is doing things now when all sorts of multimodal meds failed.

on s/e well if we remember that some of the known s/e NSAIDs include fatal haemorrhage, kidney and heart failure, will repeat next month on QOL alone

The look is because I tried to touch her!! And as you can see combing without ga not going to happen but who knows after a few months being less painful

RE: Solensia

Andreas Ege — Fri, 25 Jun 2021 13:05:35 GMT

We stock it, but I don't know if anybody has used it yet. Certainly hadn't had any feedback.

What I find irritating with solensia is the following statement in the datasheet: "Statistically significant difference (p<0.05) compared to placebo-treatment was demonstrated after the first and second treatment, but not after the third treatment."

That suggests it might not be that useful for long term treatment, but I guess we just have to see.

The other is possibly an unfounded worry on my account, but I can't help wondering what long term effects it may have to knock out a growth factor that not only helps with nerve repair and regeneration, but also plays a role in wound healing, immune system, survival of pancreatic cells and more (at least in humans). For that reason I'd probably only would use it if all other options have been exhausted or the owner insists.

RE: Solensia

Neil Wheadon — Tue, 22 Jun 2021 21:29:45 GMT

Silent cats?

Our ginger cat has gone from strength to strength, it's taken years off him. He's used the litter tray once and is eating his head off, has gained weight as well. He no longer looks 14

My wife had a client in today on Lebrela, similar comments

Neil

RE: Solensia

janine redman — Tue, 22 Jun 2021 21:06:26 GMT

Cerenia makes patients calm and serene, convenia is convenient to use , librelia give liberty and freedom from arthritis , solensia ??

RE: Solensia

Bob Russell — Tue, 22 Jun 2021 14:32:55 GMT

Why on earth do they keep using these stupid made up names that are meaningless? Cerenia, Convenia, Lebrela, Solensia.

Could we just have a tiny hint in the title in future?

RE: Solensia

janine redman — Mon, 21 Jun 2021 22:02:22 GMT

All the dogs , n=. 4 have done well so far . A couple of cats due to start solensia this week

janine

RE: Solensia

Stephen Courtney — Sat, 19 Jun 2021 20:37:44 GMT

I've just started to use both this and Librela. So far ( n=3) no feedback yet, but very pleased to read Neil's comment!

RE: Solensia

Neil Wheadon — Fri, 18 Jun 2021 10:57:52 GMT

Meanwhile, Maia the receptionist asked how long it would take for Lobrella to work in her arthritic Labrador? I replied maybe 2-3 days. Apparently walked with no limp for the first time in ages the next day.
Does this qualify for a free bottle for our cat Zoetis?

RE: Solensia

Arlo Guthrie — Thu, 17 Jun 2021 09:02:16 GMT

[quote userid="8958" url="~/001/veterinary-clinical/small-animal/f/misc-case-discussions/29891/solensia"]So doing Arlo a favor as they have paid for an advert[/quote]

Laughed out loud.

I wonder if I could pay you to come and write nice things about all our advertisers! Joking aside, I should think someone at Zoetis will be dead chuffed to read that.

RE: Solensia

Richard Carter — Thu, 17 Jun 2021 08:40:54 GMT

Have a very stiff nodding kitty not improved on melox got her first injection yesterday- holding thumbs

RE: Solensia

Neil Wheadon — Wed, 16 Jun 2021 16:12:38 GMT

No, he vomitted on Metacam, so we know it's this drug alone that's having the effect and the litter tray shows it's not a placebo

Neil

RE: Solensia

Beats — Wed, 16 Jun 2021 15:57:14 GMT

[quote userid="8958" url="~/001/veterinary-clinical/small-animal/f/misc-case-discussions/29891/solensia"]Our 14 year cat has gone...........to be replaced by a brand new, spanking ball of ginger happiness. He's back to climbing trees, jumping fences, eating better. We were having to provide a litter tray as he was stiff enough not to bother with the great outdoors, now untouched.[/quote]

brillianr.

was the solensia you gave in addition to metacam that was already on?