https://www.vetsurgeon.org/f/clinical-questions/29804/what-s-your-experience-with-amitriptyline-long-term So this guy here is Flynn - He started to chew his tail very early in life, to the point where all medications failed, eventually one of my colleagues resorted to amputate his tail. Unfortunately, this didn&#39;t help and chewing his tail continue. Ween-USTelligent Community 10https://www.vetsurgeon.org/thread/230243?ContentTypeID=1Thu, 06 May 2021 19:42:22 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:3b78471a-9ad2-467d-9340-15d43c5eb4f5Stephen Courtney<p>I would be concerned to see increase in anxiety mainly - certainly humans have to come off this stuff slowly if they have been on it for any length of time, but some of that may be a placebo effect. &nbsp;I have no experience in withdrawing it - I have 2 cats on it - one for FLUTD - works great - and one for behavioural aggression as an extension. of normal play, in a cat that is blind. Works well there too, and neither owner wants to withdraw the product&nbsp;</p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/230230?ContentTypeID=1Wed, 05 May 2021 22:11:21 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:18accaa3-34b9-4167-8c3a-23e1dd2bdfb5Dinu Catilina<p>I have one patient on it, a huge dog with sever fear aggression and even his owners were terrified of him. They say it works and the dog is better. I don&#39;t know if it will help in your case, sorry.</p> <p>Stephen, what symptoms would you expect to see if we were to stop it abruptly for whatever reason?&nbsp;</p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/230172?ContentTypeID=1Sun, 02 May 2021 18:57:51 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:bda29d99-c4f3-49fe-b18c-04ea60ea4a9cStephen Courtney<p>You can give it long term, but it cannot be withdrawn easily as the body becomes dependent - assuming that dogs respond in similar ways to humans</p> <p>If it works then give it in good conscience, because to be honest there is very little else to try as an alternative, and &nbsp;results will always be a gamble&nbsp;</p><div style="clear:both;"></div>