https://www.vetsurgeon.org/f/clinical-questions/29746/feline-lymphoma-anatomical-classification I have a case where an abdominal mass in an 11 year old cat was found to be a T cell lymphoma on histology/immunohistochemistry. In surgery the mass was noted to be extending from the pancreas to the colon and biopsies were taken from the mass and theen-USTelligent Community 10https://www.vetsurgeon.org/thread/229974?ContentTypeID=1Tue, 20 Apr 2021 09:10:55 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:bce67eb2-38bf-4f80-a7ef-25a55e4386ecCatherine Welsh<p>Hi Rodney,</p> <p>Thank you so much for taking the time to reply, that&#39;s really useful!</p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/229823?ContentTypeID=1Mon, 12 Apr 2021 20:42:23 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:042d96a7-1181-431c-bd10-25ca0fac491dRodney Ayl<p>Hi,</p> <p>Many studies have shown that though anatomic location may have some prognostic significance, response is more dependent on grade and immunophenotype. Every case is different though and they don&#39;t always follow the rules, so they are always worth treating and you will soon know how well they will respond.</p> <p>This lymphoma likely started in the mesentery and progressed from there; it sounds pretty multicentric now, though not the classic nodal form. Cats are unusual though, and definitely don&#39;t follow the rules.&nbsp;</p> <p>I have found that the most important negative prognostic factors are; how&nbsp;sick they are at the begining of treatment, CNS or bone marrow involvement (Stage V) and of course T-cell phenotype, but even that is not cut in stone; some T-cell can do great and some B-cell not so much.</p> <p>Hope that helps,and is not too confusing!</p><div style="clear:both;"></div>