https://www.vetsurgeon.org/f/clinical-questions/29712/possible-reoccurrence-of-dlbcl-in-a-dog Hello, I saw a 7 y.o. MN labradoodle with a small round lump approx 2 cm diameter in front of the L shoulder. This dog finished a CHOP protocol for a high grade diffuse large B cell lymphoma in Oct 2020 and is otherwise very well, with the exceptionen-USTelligent Community 10https://www.vetsurgeon.org/thread/229819?ContentTypeID=1Mon, 12 Apr 2021 20:26:16 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:57dcf94b-13d0-4951-bf71-99a329754a18Rodney Ayl<p>Hi,</p> <p>Though as you suggest, a whole node biopsy is the best way to confirm the diagnosis, you could&nbsp;request a PARR Assay on those cytology slides, to attempt to confirm clonality; a positive of course, would help, a negative does not confirm reactivity.</p> <p>The longer a patient lives the more likely new clones of cancer cells can develop by random mutation, so a single new node is a possibility. I will say that with 80% atypical cells, the cytology does sound quite convincing.</p> <p>Since the owners are strapped for finances at the moment, treatment options are limited anyway, so a conservative palliative protocol just with oral medications, may be the way to go.</p> <p>Hope this helps!</p><div style="clear:both;"></div>