Use of oclacitinib or prednisolone in dog with low Leishmania titre

RE: Use of oclacitinib or prednisolone in dog with low Leishmania titre

Delia Richter — Thu, 28 Jan 2021 12:19:36 GMT

I did offer a cytopoint injection, but the owner is going with trying antihistamines, and some douxo calm, while we wait to see if it settles now that we've killed off (hopefully) the demodex.

Thanks everyone for your help!

cheers,

Delia

RE: Use of oclacitinib or prednisolone in dog with low Leishmania titre

Thomas Johnson — Wed, 27 Jan 2021 08:23:07 GMT

[quote userid="10320" url="~/001/veterinary-clinical/small-animal/dermatology/f/discussions/29618/use-of-oclacitinib-or-prednisolone-in-dog-with-low-leishmania-titre/228100#228100"]I would have thought oclacitinib potentially slightly preferable as I believe it does not have an immunosuppressive action (though also would not expect significant immunosuppression with a short course of pred at anti-pruritic doses)?[/quote]

Would it be better to consider an injection of Cytopoint?

RE: Use of oclacitinib or prednisolone in dog with low Leishmania titre

Anthony Dennison — Wed, 27 Jan 2021 01:53:47 GMT

From the datasheet:

Oclacitinib modulates the immune system and may increase susceptibility to infection and exacerbate neoplastic conditions. Dogs receiving Apoquel tablets should therefore be monitored periodically with complete blood counts and serum biochemistry when on long-term treatment.

When treating pruritus associated with allergic dermatitis with oclacitinib, investigate and treat any underlying causes (e.g. flea allergic dermatitis, contact dermatitis, food hypersensitivity). Furthermore, in cases of allergic dermatitis and atopic dermatitis, it is recommended to investigate and treat complicating factors, such as bacterial, fungal or parasitic infections/infestations (e.g. flea and mange).

Not sure it would be advisable in a possible leishmania case.

RE: Use of oclacitinib or prednisolone in dog with low Leishmania titre

Lucy Fleming — Tue, 26 Jan 2021 00:50:23 GMT

I would have thought oclacitinib potentially slightly preferable as I believe it does not have an immunosuppressive action (though also would not expect significant immunosuppression with a short course of pred at anti-pruritic doses)?

Worth a chat with the technical team at zoetis first though. I don't know where you are based but I believe Emi Barker at Langford has an interest in Leish and may be happy to advise?

(and take my advice with a huge pinch of salt as I'm post-GA myself and scrolling VetSurgeon as I can't sleep!)

RE: Use of oclacitinib or prednisolone in dog with low Leishmania titre

Delia Richter — Thu, 21 Jan 2021 14:56:01 GMT