https://www.vetsurgeon.org/f/clinical-questions/29339/what-chemotherapy-protocol-should-i-use-for-a-cranial-mediastinal-t-cell-lymphoma 11 year old Labradoodle. Cranial mediastinal exfoliating T-cell lymphoma with secondary paraneoplastic eosinophilic inflammation. Diagnosed via radiography and cytology/flow cytometry on effusion. What chemotherapy protocol would be most appropriateen-USTelligent Community 10https://www.vetsurgeon.org/thread/225265?ContentTypeID=1Fri, 04 Sep 2020 14:00:15 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:9fba942b-b199-4076-b038-6902b69b8950Rodney Ayl<p>Hi Rob,</p> <p>Most intermediate to high grade lymphomas would be treated initially with a CHOP-based protocol, even T-cell, often adding l-asparaginase in at the beginning with cranial mediastinal disease, to help to reduce the mass effect quickly, if it is compromising breathing. If I do not get a good response within the first cycle in a T-cell, I will probably switch to lomustine, often along with l-asparaginase. If it is low grade I sometimes consider surgery and/or radiation to get a more rapid resolution of the mediastinal mass.</p> <p>Hope this helps!</p> <p>KR, Rodney Ayl</p><div style="clear:both;"></div>