Epilepsy medications, other options.

RE: Epilepsy medications, other options.

Claire Godfrey — Sun, 20 Sep 2020 07:42:30 GMT

The MRI report shows little change from 4 years ago. Referral have increased medication quite a lot and currently reduction in seizures. Have discussed testing for laforas and planning this next tine he is in for other blood tests. Thank you for your input.

RE: Epilepsy medications, other options.

Claire Godfrey — Tue, 25 Aug 2020 21:59:16 GMT

Thank you for your reply.

He was referred yesterday for a repeat mri, the last one was 4-5 years ago. Just waiting for referral report but hoping we can do something for him as fits have increased since my last post.

Claire

RE: Epilepsy medications, other options.

Mark Lowrie — Tue, 25 Aug 2020 20:29:43 GMT

Hi Claire, hoping I’m not too late to the party here. I’d strongly recommend testing for Lafora disease. The DNA test is here:

https://www.laboklin.co.uk/laboklin/showGeneticTest.jsp?testID=8005

It won’t change your management but will give help as this is a degenerative condition with little improvement expected with meds and would explain blindness and aggression as well as normal MRI. Levetiracetam is the best drug in this scenario.

If negative then really you’d have to balance side effects of drugs with problems from seizures and their Likelihood for causing blindness and aggression post it ally. This should be owner led but I’d suggest pheno is unlikely to cause blindness so worth restarting at low dose (2.5mg/kg BID) and doing pheno conc after 3 weeks to ensure This dog is not too sensitive to the drugs.

Do post back if you have an update.