https://www.vetsurgeon.org/f/clinical-questions/29101/why-is-allergy-serology-screening-not-that-clinically-relevant-in-feline-medicine From my experience, the allergic condition management plan (including response to Immune suppressants) is not as easy to formulate and to achieve good control of clinical signs as it may be in dogs, even with the knowledge of potential triggering allergensen-USTelligent Community 10https://www.vetsurgeon.org/thread/222763?ContentTypeID=1Wed, 20 May 2020 12:55:14 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:0dbb9e42-af0e-4d64-b124-e3a991c593ccDavid Bentley<p>The problem with cats is actually getting to a diagnosis of Non-flea, non food, allergic dermatitis in the first place. &nbsp;There is a large amount of overlap in clinical signs between &nbsp;flea &nbsp;allergy, adverse food reactions and &ldquo;Atopy&rdquo; although some signs , eg facial pruritus, are more likely to be seen with food allergy or Atopy . So, when looking at eosinophilia &nbsp;granuloma complex, alopecia from overgrooming , milary dermatitis, etc etc all 3 hypersensitivities have to be considered along with various other &nbsp;bacterial fungal and parasitic diseases. &nbsp;There is a large amount of work-up that needs to be done before considering allergy testing (either Intradermal skin testing or serological testing) &nbsp;and as in dogs, these are really only worth doing if one is going to try allergen specific immunotherapy . &nbsp;It is sometimes very difficult to confirm a diagnosis of an adverse food reaction as some cats are impossible to successfully food trial.</p> <p>The other thing about serological testing is that the role of IgE in feline atopic syndrome has not been completely clarified, hence the term Feline atopic syndrome rather than Feline Atopy. &nbsp;Also, just as in dogs, false positives can occur with both IDST and serology so it is vital that everything else has been ruled out first before even considering these tests.</p><div style="clear:both;"></div>