Metronomic cyclophosphamide and meloxicamhttps://www.vetsurgeon.org/f/clinical-questions/29048/metronomic-cyclophosphamide-and-meloxicam Question for the clever people - am aware of lots of combinations with metronomic chemo using prednisolone in combination with other chemo agents but how good (or dangerous) is metronomic chemo at low dose 10mg/m2 cyclophosphamide sid alongside standarden-USTelligent Community 10RE: Metronomic cyclophosphamide and meloxicamhttps://www.vetsurgeon.org/thread/224987?ContentTypeID=1Wed, 19 Aug 2020 22:01:29 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:cce2bb12-d25e-4134-85b2-8b6b6b1dba41Ex Member<p>Dear Richard, not knowing the details of the case, in a oatient with asac, I would use meloxicam alongside toceranib due to its activity against this tumour. In general instead for metronomic chemo we use cyclophosphamide (15 mg/m2 sid-eod) alongside frusemide (1 mg/kg) with each dose of cyclophosphamide and meloxicam. Pred is not generally part of metronomic protocols unless you are treating a lymphoma or mast cell tumour with chlorambucil for example. Hope this helps, if not ask more!</p><div style="clear:both;"></div>RE: Metronomic cyclophosphamide and meloxicamhttps://www.vetsurgeon.org/thread/222076?ContentTypeID=1Mon, 27 Apr 2020 18:30:55 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:527ca167-18aa-4393-9f26-5c884aa05c37Charlotte Marshall<p>The metronomic protocol I have used was cyclophosphamide with firocoxib. Mind you the last dog I gave it to developed hepatitis after about 4 months so she isn&#39;t getting any more! &nbsp;</p><div style="clear:both;"></div>RE: Metronomic cyclophosphamide and meloxicamhttps://www.vetsurgeon.org/thread/222000?ContentTypeID=1Thu, 23 Apr 2020 09:16:40 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:7b099e97-ed5c-4f95-9b85-cef1175b6df2Anthony Dennison<p>I imagine Gerry will be along again to correct me, but often the metronomic protocols recommend use of piroxicam with another agent, but meloxicam has a similar mode of action but with less side effects. I&#39;ve seen many cases on both drugs.</p> <p>Worth using once daily furosemide as well if wanting to start on cyclophosphamide (something else Gerry said on a recent thread about the drug).</p><div style="clear:both;"></div>