https://www.vetsurgeon.org/f/clinical-questions/28910/transitional-cell-tumour-in-urethra-prostate Had look through the search to see if any recent discussions on advances on metronomic rx for TCC in prostate with high mitotic index 18-20/10 hpf beyond the classic NSAID route? we can get chlorambucil as suggested 5 years ago by Jerry, we also likeen-USTelligent Community 10https://www.vetsurgeon.org/thread/219692?ContentTypeID=1Fri, 21 Feb 2020 17:10:50 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:f9a4582b-92fa-4239-b1ef-26c2d920c634Richard Carter<p>thanks so much for the help - dog is well, urinating fine, just a persistent haematuria at present and we discovered it when we couldn&#39;t get a cathetre into the bladder on u/sound, and then confirmed on biopsy</p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/219685?ContentTypeID=1Fri, 21 Feb 2020 11:45:27 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:d3c76cc4-1393-49e6-b5e4-f5c02a128de2Andrew Kent<p>Hi Richard,</p> <p>I think this depends a lot on the clinical symptoms of the patient. I will sometimes use metronomic in patients with minimal clinical signs but if markedly symptomatic you tend to need something else first (stent, conventional chemo etc).</p> <p>More often I use metronomic if there has been a good response to conventional chemotherapy to see if we can maintain that benefit - I have typically used chlorambucil for that purpose.</p> <p>Sure this is a situation where everybody does something a bit different!</p> <p>Andy</p><div style="clear:both;"></div>