https://www.vetsurgeon.org/f/clinical-questions/28815/rapamycin Had a client asking about Rapamycin for dog ageing. I think they&#39;d read about it in relation to the Dog Aging Project in the US who are doing a trial on it and have published some early study ( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411365/ )en-USTelligent Community 10https://www.vetsurgeon.org/thread/218865?ContentTypeID=1Fri, 17 Jan 2020 21:32:39 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:0036c1eb-5134-4042-ab7b-97ab5c3ed1a4Beats<p>I&#39;m not sure that study tells me anything, but i&#39;d need to check with a cardiologist! A 10 week study is unlikely to conclude that rapamycin might be a life-lengthening drug.</p> <p>In the event that I was wishing to spend money on a medicine that may increase the life expectancy of my dog non-specifically, I don&#39;t think rapamycin (based on this) is a strong contender currently.</p> <p>Propentofylline? Nicergoline? Pimobendan? VitaminE? All potential alternative contenders?</p> <p>Has anyone ever seen a side effect from pimobendan? If giving a dog a medicine on the hope if may extend its lifespan, I&#39;d probably choose pimobendan based on what I know to-date?</p> <p>I think panaceas are rare, but come in fads. When I was at school a teacher suggested that taking a little aspirin a day may lengthen our lives - I think that fad has ended?</p> <p>I would predict this will come to nothing, but one never knows.</p> <p>I saw a dog today that I removed a splenic hemangiosarcoma from over 2 years ago now. Indeed my last 4 splenic haemangiosarcoma-dogs are all alive and well. There can be only one explanation - I used catgut. Do you think this will start a craze?</p> <p>What I&#39;d like to see is one of these big data things looking at dog castration and life expectancy - perhaps this has been done already? And cat vaccines and CKD - maybe a bit harder to get the data on that one? And annual anesthetic for dental work and life expectancy?</p><div style="clear:both;"></div>