Tranexamic acid solution

RE: Tranexamic acid solution

Alistair Graham-Evans — Sat, 23 Nov 2019 00:58:04 GMT

I use Tranaxamic acid for greyhounds and some trauma cases and organ rupture. Never heard of it being used topically though.

"Tissue plasminogen activator (tPA) is a naturally occurring fibrinolytic agent found in vascular endothelial cells and is involved in the balance between thrombolysis and thrombogenesis. It exhibits significant fibrin specificity and affinity. At the site of the thrombus, the binding of tPA and plasminogen to the fibrin surface induces a conformational change that facilitates the conversion of plasminogen to plasmin and dissolves the clot"

So as it appears to work within the clot Tranexamic acid may work locally if it can dissolve into the clot? So I presume more effective if already in the blood and is incorporated into the clot as it forms?

Presumably Vetigel activates platelets in some way ( like Gelita sponges) but I note the human Traumagel product is still undergoing testing at present.

RE: Tranexamic acid solution

Beats — Fri, 22 Nov 2019 21:02:53 GMT

Anyone every used Vetigel?

https://cresilon.com/vetigel/

RE: Tranexamic acid solution

Lindsey Edwards — Sat, 16 Nov 2019 20:44:01 GMT

Would love to hear of anyone using topically?

I use celox for such cases (teeth/enucleations etc) to good effect but topical TXA on a temporary dressing would be interesting!

RE: Tranexamic acid solution

Dinu Catilina — Sat, 16 Nov 2019 19:40:17 GMT

I use the injectable form pre anaesthetic in greyhounds and ocntinue with tablets for 5 days.

We had an interesting case recently with an american bully female who bled extensively throughout the season. She was spayed and was fine at the time of surgery. Started bleeding copiously 4 days after surgery from the abdominal wound. No obvious abdominal haemorrhage on ultrasound. Had tranexamic acid inj and continued with tablets. I suspect some kind of fybrinolitic episode like in greyhounds.

RE: Tranexamic acid solution

jane alexander — Thu, 14 Nov 2019 15:34:03 GMT

Were you asking about using the medication as a solution to irrigate the bleeding area?

I had a greyhound, only yesterday, with copious bleeding arising from alongside an incisor tooth, with no history of trauma, according to the owner, and no obvious cause. Prescribed tablets, but might have been useful topically?

RE: Tranexamic acid solution

Anthony Dennison — Mon, 11 Nov 2019 12:08:39 GMT

Yes it has - often used pre-operatively in greyhounds due to the risk of fibrinolytic disorder.

See this Vet Times article:

https://www.vettimes.co.uk/article/delayed-postoperative-bleeding-in-greyhounds/?format=pdf