primary ciliary dyskinesia

RE: primary ciliary dyskinesia

Sarah Keir — Wed, 02 Oct 2019 11:17:36 GMT

Primary ciliary dyskinesia was a topic at the SAMSoc Autumn meeting last year. Not much extra to add to that above but I will read through the notes and see if anything extra. The summary was most cases are diagnosis by presumption, it is genetic in some families of dogs but can occur spontaenously in any breed and they don't tend to live long. The other thing I remember is that homozygous dogs tend to have fertility problems as there are cilia in the follopian tubes that move the eggs along.

RE: primary ciliary dyskinesia

Lucy Fleming — Tue, 01 Oct 2019 17:06:09 GMT

[quote user="Richard Carter"]the inverted organs - heart above the lungs from the CT scan? Heart appears in normal position on lateral chest xrays with trachea and bronchi above the heart base[/quote]

It's a left-to-right inversion, so the great vessels are reversed, spleen on opposite side etc.

We have seen one, a ridgeback. As far as I'm aware he's still alive, though we haven't dispensed any meds to him recently, so perhaps he is not ....My understanding was all of his littermates had already been PTS some time ago.

RE: primary ciliary dyskinesia

Richard Carter — Tue, 01 Oct 2019 13:31:21 GMT

these are tibetan terriers. the inverted organs - heart above the lungs from the CT scan? Heart appears in normal position on lateral chest xrays with trachea and bronchi above the heart base

the human side seems to rely on antibiotics, mechanical percussion treatment and lung transplant....

the problem with suggesting euthanasia is that when these guys are well, they are normal growing pups but as there seems to be nothing except endless antibiotics in their future, may be the kind option

currently on 3 weeks doxycycline - will see how long they last when off

RE: primary ciliary dyskinesia

vs0u — Tue, 01 Oct 2019 11:58:53 GMT

A friend's Welsh terrier had it. Was rescued at age 8 months, always had diarrhoea and and appeared to get respiratory problems shortly afterwards (although may have had issues before of course). Dog went for referral and ended up on steroids and nebuliser but was eventually euthanased after a year or so due to welfare concerns over repeated pneumonia.

RE: primary ciliary dyskinesia

Andrew Kent — Mon, 30 Sep 2019 20:20:17 GMT

Hi Richard,

Certainly this would seem a possibility - as Nick says the presence of situs inversus can be suggestive.

Diagnosis can be by electron microscopy on an endoscopically obtained biopsy sample - we have had these analysed at Liverpool previously.

Andy

RE: primary ciliary dyskinesia

nick shackleton — Mon, 30 Sep 2019 18:58:06 GMT

I looked to write a case report but struggled to find much research in the topic. Think it’s common in old English sheepdogs

RE: primary ciliary dyskinesia

nick shackleton — Mon, 30 Sep 2019 18:54:22 GMT

I’ve seen it in in a ridgeback. The dog had situs inversus as well which is also clinical indication for PCD. The dog was referred for work up for nasal discharge. CT was performed. Again this breed is not on the ‘type’ for genetic list. I no longer work at the practice where the patient was seen. Primarily the patient‘s pneumonia was treated with antibiotics