Antibiotic use but chronic hepatic enzyme abnormalities.

RE: Antibiotic use but chronic hepatic enzyme abnormalities.

Clive Ansell — Fri, 28 Jun 2019 12:19:46 GMT

[quote user="David Mills"]

Is this representative?

Profuse growth of more than one organism is generally a sign of contamination rather than pathology.

[/quote]

How would one know either way?

I guess just treat according to the results available.

Care is advised in the data sheet with Doxycycline and hepatic impairment, so does one use that or dive straight in with a fluoroquinolone? I think I would use Doxycycline and then assess response to treatment after 2 weeks.

RE: Antibiotic use but chronic hepatic enzyme abnormalities.

Andrea Tarr — Fri, 28 Jun 2019 09:58:08 GMT

Doxycycline’s elimination from the body is relatively unique. The drug is primarily excreted into the feces via nonbiliary routes in an inactive form. The drug is thought to be partially inactivated in the intestine by chelate formation and excreted into the intestinal lumen. In dogs, ≈75% of a dose is handled in this manner. Renal excretion of doxycycline can only account for ≈25% of a dose in dogs, and biliary excretion can only account for <5%. Nevertheless, because increases in hepatic enzymes have been documented in some dogs after doxycycline treatment, this drug should be used with caution in dogs with significant liver dysfunction.

Pradofloxacin is primarily metabolized via glucuronidation and sulfation; approximately 40% of a dose is excreted in the urine. Approximately 85% of a dose is excreted into the urine within 24 hours—40% unchanged and the rest primarily as glucuronide metabolites. Use with caution in animals with severely impaired hepatic function.

Source Plumb's Veterinary Drugs

RE: Antibiotic use but chronic hepatic enzyme abnormalities.

David Mills — Fri, 28 Jun 2019 08:14:23 GMT

Is this representative?

Profuse growth of more than one organism is generally a sign of contamination rather than pathology.

RE: Antibiotic use but chronic hepatic enzyme abnormalities.

Karen Eggleton — Fri, 28 Jun 2019 07:45:58 GMT

Thank you! Not best quality but attached. Slightly concerning. Had amox and cephalexin recently but not been subjected to much antibiotic use previously.

RE: Antibiotic use but chronic hepatic enzyme abnormalities.

Beats — Thu, 27 Jun 2019 21:07:32 GMT

I'm sure doxy would be fine re slightly suspect liver, but think it is eliminated in the bile from memory? whereas oxytet is eliminated mostly unchanged in urine - not saying that makes it a better choice necessarily, but thought worth mentioning in case was a consideration to ruminate on.

(The re-formulated 4-way splittable 200mg oxycare tablets from Animalcare are a significant improvement in my mind meaning no longer have to stock 3 different tablet size tubs amongst other perks, though a quarter/half doesn't go down a cat's throat as easy as the old 50's/100's did).

[would be interested to see the culture and sensitivity report if easy to upload in an anonymous fashion]