https://www.vetsurgeon.org/f/clinical-questions/28319/guinea-pig-weight-loss Hey guys, wondering if anyone knows the significance of slight elevations in AST,LDH and total bilirubin in a guinea pig that’s losing weight? She is eating less (but still eating). dental exam and dental rads NAD, HR and T4 WNL, both kidneys palpateen-USTelligent Community 10https://www.vetsurgeon.org/thread/212841?ContentTypeID=1Sat, 22 Jun 2019 16:46:51 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:2a3b3488-25ab-4d06-bb75-c21a6d747eb2Sheryl Calway<p>Thanks Marie,</p> <p>The calcium was 2.81 and phosphorus 0.61, so I thought within normal limits. But ultrasound scan sizes were R kidney 3.07 cm and L 2.7...so both enlarged based on the range you give.&nbsp;</p> <p>She&#39;s coming back in on Monday, so I&#39;ll try again to obtain a urine sample (failed miserably last week!!)...but I&#39;m puzzled as to what could be causing enlarged kidneys, weight loss...but little renal changes on bloods...?</p><div style="clear:both;"></div>https://www.vetsurgeon.org/thread/212754?ContentTypeID=1Thu, 20 Jun 2019 14:05:31 GMT146601cc-3922-4be7-9974-7e1d4e45a66b:7cc487ac-63fc-4a9c-bb83-9b95133bed49Marie Kubiak<p>AST and LDH can increase with reduced renal clearance which may be relevant given the palpable renal changes but both enzymes are very non-specific. What were Ca and Phos? These tend to be more useful for assessment of renal compromise in small herbivores. Were kidney&#39;s enlarged? Length is variable (associated loosely with bodyweight) but 17-26mm is reported as a normal range. Urinalysis would be helpful - I tended to keep GPs in a plastic cage until a sample was passed or get owners to do this at home.</p> <p>Marie</p><div style="clear:both;"></div>