Juvenile diabetes mellitus

RE: Juvenile diabetes mellitus

topaz koch — Thu, 09 May 2019 10:07:16 GMT

Thanks so much for this, yeah I think he was a partic bad case. Good to know others are unlikely to go the same way.

RE: Juvenile diabetes mellitus

Ian Ramsey — Thu, 09 May 2019 09:46:56 GMT

Hi,

Thanks for posting this case. My experience is that juvenile diabetics do as well as any diabetic - which is to say that they very often get cataracts and removing them improves their (and their owners) quality of life. They are often easy to stabilise as they usually do not have significant co-morbidities.

Greyhounds have been recognised to have a more severe syndrome that presents as pancreatic hypoplasia and this has also been reported sporadically in other breeds. So I agree checking a TLI is sensible (but if the dog does not have diarrhoea then it is not essential). These cases are harder to manage but from the literature successful management is not impossible either.

There are no published case series of juvenile diabetics that I am aware of so it is hard to provide any better evidence than personal ancedote - FWIW we have several that have survived 7 plus years.

I would not be too pessimistic!

Best wishes

Ian

J Vet Intern Med. 2009 Jan-Feb;23(1):67-71. doi: 10.1111/j.1939-1676.2008.0214.x.

Juvenile pancreatic atrophy in Greyhounds: 12 cases (1995-2000).

Brenner K1, Harkin KR, Andrews GA, Kennedy G.

Abstract

BACKGROUND:

This study describes compound failure of the endocrine and exocrine pancreas in Greyhounds, a condition that has not been reported in the veterinary literature.

OBJECTIVE:

To describe the clinical and pathologic findings in 12 Greyhounds with juvenile pancreatic atrophy.

ANIMALS:

Ten Greyhounds presented for necropsy examination and 2 sibling Greyhounds presented for clinical evaluation before necropsy, all with a history of small-bowel diarrhea.

PROCEDURES:

Retrospective study of laboratory and pathologic findings in 12 Greyhounds, including serum trypsin-like immunoreactivity assays, oral glucose tolerance testing, and serum anti-insulin antibody concentrations.

RESULTS:

Gross pancreatic atrophy was found in all 12 dogs. Histopathologic lesions were found in both the endocrine and exocrine pancreas and included acinar cell apoptosis, zymogen granule loss, cytoplasmic clearing or vacuolar change, lobular atrophy, islet loss, and lymphocytic or lymphoplasmacytic pancreatitis. Antemortem test results on the 2 Greyhound puppies indicated concurrent exocrine pancreatic insufficiency (EPI) and insulin-dependent diabetesmellitus (IDDM).

CONCLUSIONS AND CLINICAL IMPORTANCE:

Compound failure of the exocrine and endocrine pancreas is rarely reported in dogs and neither disease is well recognized in the Greyhound. This condition is of potential economic importance to the Greyhound racing industry.

RE: Juvenile diabetes mellitus

topaz koch — Thu, 09 May 2019 07:52:43 GMT

We had one a few weeks ago in a young greyhound. Presented as dka. Suspected to be pancreatic hypoplasia. Started treating and was responding but then acutely deteriorated and went shocky so was euthanased. Apparently can be part of a multi organ immune mediated disease or can be congenital hypoplasia. Tli is worth to check to further assess pancreatic function. Very sad cases though.

RE: Juvenile diabetes mellitus

janine redman — Wed, 08 May 2019 23:07:42 GMT

Seen at referral ophthalmologist and confirmed juvenile DM with cataracts

RE: Juvenile diabetes mellitus

Joyce Whitehead — Wed, 08 May 2019 18:54:07 GMT

I’ve had one juvenile diabetic, a 10 week old JRT, presented unwell, vomiting, PD/PU. Never occurred to me it was diabetic and at first I didn’t do a blood glucose and we really struggled to get a urine sample. But when we finally did the urine was full of it, and the BG was sky high too. I spoke to a medicine specialist who said it was very rare but had been seen, he was quite excited at the prospect. Unfortunately the owners opted for euthanasia, having thought through the implications. Not a bad decision to be fair, the pup was quite sick already. I’m sure congenital renal issues may also be a possiblitly though, interesting case!