RE: Fibrinolytic syndrome

Lindsey Edwards — Mon, 29 Apr 2019 19:28:26 GMT

I see very few incidences with a high caseload of Irish greyhounds (3-5 cases per year would require TXA); does seem to run in certain lines however. If this is a recent increase in cases and unrelated dogs I would also check for lungworm as can also give similar bleeding crises

RE: Fibrinolytic syndrome

Sarah Cochrane — Sat, 27 Apr 2019 22:45:48 GMT

Its fairly common but varies by line/pedigree and also by nationaliity of parentage (UK bred vs Irish vs Aus vs USA)

I couldn't find any stats on UK greyhounds, but this from an observation by Guillermo Couto: "For example, in the US, approximately 10% of Greyhounds from racing blood lines die due to hemostatic problems (Lord et al, attached), whereas when we did a health survey of AKC Greyhounds, we had zero with bleeding issues. Moreover, racetrack vets perceive that some blood lines have a high prevalence of hemostatic disorders, but we could not prove it by doing pedigree analysis since we did not know the outcome of the “non-bleeder” littermates.

During our years of providing free spay/neuter/dental clinics for Greyhounds, 26% experienced postoperative bleeding (Lara et al, attached), and a similar proportion showed bleeding AND viscoelastographic changes in a prospective study (Vilar Saavedra et al, attached). In contrast, we spent 12 years doing spay/neuter clinics in Galgos in Spain, and never saw a single bleeding episode.

In my days in the University we had a very high Greyhound caseload (approximately 1,000 visits per year in my last few year there), and did quite a few amputations for osteosarcoma (40-80/year); the prevalence and severity of bleeding before starting to use EACA was unacceptable (approximately 40% of dogs required hemostatic support). For hind limb amputations performed by board-certified (ACVS) surgeons, my transfusion record is 26 units of blood products, 5 weeks in the clinic, and an almost $20,000 bill for a 6 year old FS Greyhound! (Marin et al, 2012)."

It's worth routinely giving TXA or aminocaproic acid prior to surgery and continuing afterwards for 5 days or so.

RE: Fibrinolytic syndrome

Rob Davis — Sat, 27 Apr 2019 18:24:52 GMT

We have seen a couple. This article suggests 5-10mg/kg TID for 5 days.

RE: Fibrinolytic syndrome

Peter Faulkner — Sat, 27 Apr 2019 10:55:19 GMT

Hi Alistair,

Sounds a good idea. We have exactly the same problem, especially with dentals. What dose do you use?