Cytopoint or Apoquel in cats?

RE: Cytopoint or Apoquel in cats?

Rob Loxley — Tue, 17 Dec 2019 16:56:04 GMT

I'd consider atopica (or 'generic') or if wanting to stay with steroid then have also had good success with dexamethasone injectable given per os (in food)

RE: Cytopoint or Apoquel in cats?

Bob Russell — Tue, 17 Dec 2019 11:41:29 GMT

My belief is that antihistamines are more useful in cats than dogs. This may be the result of a bit of sedation or wishful thinking. Not convinced enough on their own but corticosteroid 'sparing'? Available as liquids and fairly benign drugs to try.

RE: Cytopoint or Apoquel in cats?

Kate Richardson — Sun, 15 Dec 2019 12:09:17 GMT

[quote user="Beats"]

[quote user="Kate Richardson"]Just my experience- has any one else found this?[/quote]

I've only used ciclosporin in cats three times:

1. A diabetic cat with non-flea, non-food hypersensitivity dermatitis (NFFHD).

2. A cat with obstructive calcium oxalate urolithiasis and NFFHD.

3. A 9.8kg itchy cat which had been getting regular depo-medrone injections and I thought was at risk of diabetes...

All 3 cats I started at full dose and had no known GI side effects [of course outside defecation can hide runny poo happening].

I personally just can't see any advantage to ciclosporin over corticosteroids unless a cat is diabetic (or thought to be at especially high risk) or has calcium oxalate.

[/quote]

must have just been unlucky! Agree little advantage unless those situations- but wouldn’t be too concerned re calcium oxalate- I know it promotes calcium excretion but it also causes diuresis, and pred would be my treatment of choice for idiopathic hypercalcaemia

RE: Cytopoint or Apoquel in cats?

Beats — Sun, 15 Dec 2019 09:03:01 GMT

[quote user="Kate Richardson"]Just my experience- has any one else found this?[/quote]

I've only used ciclosporin in cats three times:

1. A diabetic cat with non-flea, non-food hypersensitivity dermatitis (NFFHD).

2. A cat with obstructive calcium oxalate urolithiasis and NFFHD.

3. A 9.8kg itchy cat which had been getting regular depo-medrone injections and I thought was at risk of diabetes...

All 3 cats I started at full dose and had no known GI side effects [of course outside defecation can hide runny poo happening].

I personally just can't see any advantage to ciclosporin over corticosteroids unless a cat is diabetic (or thought to be at especially high risk) or has calcium oxalate.

RE: Cytopoint or Apoquel in cats?

Kate Richardson — Sun, 15 Dec 2019 08:50:59 GMT

I think we do forget to consider the injectable route for long term meds’ in cats as an option, I know I do.

Cyclosporin liquid is worth trying if affordable, but just like dogs an take 2-4 weeks to good effect, and I also find commonly get GI side effects if I start on full dose so I generally start on 1/4 dose for a 5-7 days and build up gradually, so can take longer to full effect, thus may need some corticosteroid on board while transferring. Just my experience- has any one else found this?

RE: Cytopoint or Apoquel in cats?

Beats — Sat, 14 Dec 2019 22:17:04 GMT

[quote user="Thomas Johnson"]

[quote user="Beats"]2mg/ml injectable dex eg colvasone is often cheaper (and on any practice's shelf usually) starting dose fpr average cat maybe 0.2ml daily for 5 days, then twice weekly.[/quote]

Wound it be practical to teach the owners to inject the cat at home? When I'm talking to owners of newly diagnosed diabetic animals I often discuss with them that for a lot of cats injecting them is easier than tabletting them.

[/quote]

To clarify, I meant giving injectable dex orally at home.

I have no objections to doing injections at home (I used to suggest this for furosemide administration also on rare occasions), but I actually think an oral liquid is generally easier for most owners.

Id be more likely to do depo-medrone as needed [i do this commonly] than dex injections at home, but I guess in a specific case I may consider it - just hasn't cropped up for me yet.

I find teaching owners to inject cats is not always that easy...

RE: Cytopoint or Apoquel in cats?

Richard Carter — Sat, 14 Dec 2019 16:15:47 GMT

have a couple of cats on cyclavance (cyclosporin) liquid - seems to be well tolerated, easy to give

RE: Cytopoint or Apoquel in cats?

Thomas Johnson — Sat, 14 Dec 2019 08:34:51 GMT

[quote user="Beats"]2mg/ml injectable dex eg colvasone is often cheaper (and on any practice's shelf usually) starting dose fpr average cat maybe 0.2ml daily for 5 days, then twice weekly.[/quote]

RE: Cytopoint or Apoquel in cats?

Emily Rainbow — Fri, 13 Dec 2019 22:14:41 GMT

Also consider atopica instead of steroids (and comes as a liquid).

also come report suggesting maropitant is useful for allergic priorities in cats too!

RE: Cytopoint or Apoquel in cats?

Kate Richardson — Fri, 13 Dec 2019 21:20:05 GMT

Chicken flavoured pred suspension from BOVA.

RE: Cytopoint or Apoquel in cats?

Beats — Fri, 13 Dec 2019 18:30:43 GMT

I generally prefer liquid meds for cats.

Also dexamethasone I normally prefer to preds in cats as longer half-life = less frequent dosing usually.

steroid liquids are still bitter, but doses are tiny.

4mg/ml oral suspension dexamethasone I'd give average cat 0.1ml once daily for 5 days, then twice weekly.

2mg/ml injectable dex eg colvasone is often cheaper (and on any practice's shelf usually) starting dose fpr average cat maybe 0.2ml daily for 5 days, then twice weekly.

[and, if appropriate, beef up the flea control / convince owner to actually use some, eg monthly stronghold plus or 12-weekly bravecto or either of those with monthly comfortis dosed fortnight apart from isooxazoline to allow some overlap... along with control for the non-allergic cat(s) / dog(s) in the house when applicable]

RE: Cytopoint or Apoquel in cats?

Anthony Dennison — Fri, 13 Dec 2019 15:45:36 GMT

[quote user="Vita Ra"]But the only thing is that the owner is about to give up the daily fight about the tablets.[/quote]

If the owner is struggling to give tablets, would attempting to use apoquel off label be appropriate?

RE: Cytopoint or Apoquel in cats?

Sara Ramsey — Fri, 13 Dec 2019 15:39:48 GMT

Would you consider depot steroid injections? At lowest effective dose and frequency?

Far from ideal...but can be solution when owners become despondent and the cats welfare is compromised if no medication is given.

Would try diet trial and maybe immunotherapy first if not already done.

RE: Cytopoint or Apoquel in cats?

susan paterson — Wed, 27 Feb 2019 08:02:32 GMT

Lene is correct about apoquel it can be used but at a slightly higher dose rate. It is no where near as good as it is in the Dog. and my experience is cats rapidly develop pyoderma due to the immunosuppressive effects it has.

You can use cytopoint but because it is caninised antibody cats will rapifly develop antibodies to it, so whilst it might work on the first occasion it wouldn’t after that.

Sue

RE: Cytopoint or Apoquel in cats?

Lene Boysen — Wed, 27 Feb 2019 07:49:41 GMT

Hi Vita,

As far as I know cytopoint is only produced for dogs. It is caninized antibodies, so not to be used in cats.

Apoquel is sometimes useful, dosages ranging from 0,7-1,3mg/kg BID in one study (Ortalda: The use of oclacitinib for allergic pruritus in cats, an overview) and P0,5-0,8mg/kg BID for 14 days, thereafter SID in another study by Pandolfi: Head and neck feline dermatitis: response to oclacitinib treatment.

Personally, I have used Apoquel for three cats, 2 did not respond, 1 responded well. Dosage around 0,8 mg/kg BID.

Kindest, Lene Boysen

Denmark