Hyperglobulinaemia in a 10 yr old dog

RE: Hyperglobulinaemia in a 10 yr old dog

janine redman — Sun, 03 Feb 2019 20:24:32 GMT

Hasn’t travelled , double spe spike unhelpfully come back as infection , inflammation or neoplasia !

no travel history.

will see if I can get permission for radiography

RE: Hyperglobulinaemia in a 10 yr old dog

Roland Bulkyn-Rackowe — Fri, 01 Feb 2019 15:22:14 GMT

Echo the others' thoughts about checking for myeloma. Any known travel history (Leishmania, Ehrlichia)?

RE: Hyperglobulinaemia in a 10 yr old dog

janine redman — Fri, 01 Feb 2019 14:14:38 GMT

Thanks

waiting for serum electrophoresis results . Protein level was 128 g/ dl

RE: Hyperglobulinaemia in a 10 yr old dog

Kate Richardson — Fri, 01 Feb 2019 12:54:14 GMT

Also how are the teeth? Severe dental disease will lead to markedly elevated globulin levels. Otherwise, echo above thoughts re multiple myeloma.

RE: Hyperglobulinaemia in a 10 yr old dog

Anthony Dennison — Fri, 01 Feb 2019 10:49:33 GMT

Yes, it would be good to get an idea of actually globulin levels if possible. Is the dog on any immunosuppressant therapy at the moment?

RE: Hyperglobulinaemia in a 10 yr old dog

Thomas Johnson — Fri, 01 Feb 2019 08:34:05 GMT

[quote user="janine redman"]

My colleague has asked me to comment on one our paitients that has developed such a hyperglobulinaemia that the serum when spun down was solid like set jelly. It has a Coombs positive test , a thrombocytopenia and spheroctes and signs of auto immune response. However apart from being a bit depressed it is otherwise ok and although presented for GI disease this has resolved. Ultrasound showed a hepatic and splenic enlargement but normal echogenicity, there was a mild hyperglobulinaemia of 68 last July when he had a blood test for general malaise but had been well until just after Christmas. Lymph node normal , mild reduction in appetite , motions find, no current sickness , moderate PU/PD.

Any suggestions?

[/quote]

A couple of questions, how high are the globulins? Very high globulins always make me wonder about B cell derived neoplasia such as multiple myeloma. Also with the serum, had the blood definitely clotted before it was spun down? If not this can lead to gelatinous serum.