Does anyone have any experience using Maropitant in chronic rhinitis?

RE: Does anyone have any experience using Maropitant in chronic rhinitis?

Michael Woodhouse — Sat, 02 Mar 2024 00:31:22 GMT

[quote userid="2457" url="~/f/clinical-questions/27845/does-anyone-have-any-experience-using-maropitant-in-chronic-rhinitis/243829#243829"]I'd be interested in other opinions on its use.[/quote]

I feel omeprazole is one of the most overused drugs in veterinary medicine (along with metronidazole and lets not start on small animal parasite drugs). That said, there IS veterinary evidence that PPIs do reduce reflux in our patients. Although we see few of these dogs, I don't use them routinely (or ever at all). A Spanish vet at a local referral centre sends everything home on meloxicam and omeprazole.

Good evidence summary here:

veterinaryevidence.org/.../565

RE: Does anyone have any experience using Maropitant in chronic rhinitis?

joanne mcallister — Fri, 01 Mar 2024 15:49:53 GMT

many thanks for your answers regarding maropitant and interesting to see the direction the discussion ended up!

RE: Does anyone have any experience using Maropitant in chronic rhinitis?

Gillian Mostyn — Wed, 28 Feb 2024 17:19:53 GMT

[quote userid="5012" url="~/f/clinical-questions/27845/does-anyone-have-any-experience-using-maropitant-in-chronic-rhinitis/243840#243840"]We can be held to account as M'sRCVS in our own right, and saying it's practice protocol would be no defence.[/quote]

Completely agree - and, as you can probably guess, I don't blindly follow protocol if I disagree with it. Its just that I can see the potential benefit in these dogs.

[quote userid="5012" url="~/f/clinical-questions/27845/does-anyone-have-any-experience-using-maropitant-in-chronic-rhinitis/243840#243840"]I've anaesthetised hundreds, possibly thousands, of bracycephalic dog without any known issues of vomiting or regurgitation on recovery, without the use of Maropitant or Omeprazole. [/quote]

Same. But we don't always know if reflux has happened, or whether it's caused any oesophageal irritation or damage. Even if they were inappetant for a few days post op, or develop strictures etc later, we may not consider it as a potential cause.

As I say, I'd love to be presented with any firm evidence either way.

RE: Does anyone have any experience using Maropitant in chronic rhinitis?

Clive Ansell — Tue, 27 Feb 2024 21:17:04 GMT

I've anaesthetised hundreds, possibly thousands, of bracycephalic dog without any known issues of vomiting or regurgitation on recovery, without the use of Maropitant or Omeprazole.

I'm happy using Maropitant, but before using Omeprazole it would be good to see some data or evidence thats supports using an off licence drug routinely.

[quote userid="2457" url="~/f/clinical-questions/27845/does-anyone-have-any-experience-using-maropitant-in-chronic-rhinitis/243829#243829"]Honestly? Because its practice protocol[/quote]

We can be held to account as M'sRCVS in our own right, and saying it's practice protocol would be no defence.

[quote userid="2457" url="~/f/clinical-questions/27845/does-anyone-have-any-experience-using-maropitant-in-chronic-rhinitis/243829#243829"]I know that's a lousy answer...[/quote]

It's not, it's an honest answer.

RE: Does anyone have any experience using Maropitant in chronic rhinitis?

Lucy Fleming — Tue, 27 Feb 2024 16:11:45 GMT

It's probably one of the few occasions I'd consider it potentially fairly justifiable - dogs prone to reflux having a GA and potentially being placed in positions that may increase reflux... at least if the gastric pH is slightly higher then there may be less oesophageal damage resulting.

RE: Does anyone have any experience using Maropitant in chronic rhinitis?

Gillian Mostyn — Mon, 26 Feb 2024 13:48:20 GMT

[quote userid="5012" url="~/f/clinical-questions/27845/does-anyone-have-any-experience-using-maropitant-in-chronic-rhinitis/243826#243826"]Why omeprazole? given it is not licenced in small animals, is there good enough evidence to support its use?[/quote]

Honestly? Because its practice protocol, it seems a reasonable thing to do in dogs that are so prone to reflux, and I haven't told them not to. I know that's a lousy answer...

I'd be interested in other opinions on its use.

RE: Does anyone have any experience using Maropitant in chronic rhinitis?

Clive Ansell — Mon, 26 Feb 2024 10:31:44 GMT

[quote userid="2457" url="~/f/clinical-questions/27845/does-anyone-have-any-experience-using-maropitant-in-chronic-rhinitis/243824#243824"]The practice I'm currently working in routinely use prevomax and omeprazole[/quote]

Thanks.

Why omeprazole? given it is not licenced in small animals, is there good enough evidence to support its use?

RE: Does anyone have any experience using Maropitant in chronic rhinitis?

Gillian Mostyn — Mon, 26 Feb 2024 09:24:39 GMT

[quote userid="5012" url="~/f/clinical-questions/27845/does-anyone-have-any-experience-using-maropitant-in-chronic-rhinitis/243819#243819"]Does anyone use Maropitant alongside routine brachycephalic anaesthetics?[/quote]

The practice I'm currently working in routinely use prevomax and omeprazole

RE: Does anyone have any experience using Maropitant in chronic rhinitis?

Clive Ansell — Sun, 25 Feb 2024 09:21:29 GMT

Does anyone use Maropitant alongside routine brachycephalic anaesthetics? it seemed popular for a while but seems less so now? If so, is there good evidence to support such use?

One referral centre I know used to (I'm unsure if they still do) ask that referral surgical cases, in all breeds of dog, be routinely prescibed oral Maropitant to be given by the owner the night before. is there good evidence to support this?

RE: Does anyone have any experience using Maropitant in chronic rhinitis?

Aine Seavers — Sat, 24 Feb 2024 23:08:34 GMT

So where does the Anti-SubP action fit into that stance of not having anti-inflammatory action-is the suggestion now there is no anti-SP action?

Intrigued,

Aine

RE: Does anyone have any experience using Maropitant in chronic rhinitis?

Kate Murphy — Sat, 24 Feb 2024 21:03:22 GMT

There is lack of evidence corroborating its use as an anti-inflammatory but many still use it

RE: Does anyone have any experience using Maropitant in chronic rhinitis?

Alasdair Hotston Moore — Fri, 23 Feb 2024 22:49:27 GMT

I think the idea has been debunked. Can you recall Kate Murphy

RE: Maropitant in chronic rhinitis

joanne mcallister — Wed, 21 Feb 2024 12:18:36 GMT

Just resurrecting this topic. Has anyone had any further experience using maropitant drops for chronic rhinitis in cats?

RE: Maropitant in chronic rhinitis

Aine Seavers — Sun, 03 Feb 2019 02:59:15 GMT

Excellent-good to know, tx for the info,

RE: Maropitant in chronic rhinitis

Kate Richardson — Thu, 31 Jan 2019 10:23:47 GMT

Apparently very widely used in the USA - 1ml of Cerenia in 9ml of saline, one drop on each nostril.

Anecdotal reports of it being helpful.

Not much more info at the moment I'm afraid.

RE: Maropitant in chronic rhinitis

Thomas Johnson — Thu, 31 Jan 2019 08:42:51 GMT

[quote user="Aine Seavers"]Prevomax not available in Australia so I am not clear what your reply refers to.Are you saying you have used it in the nose ?or saying it is not painful like Cerenia?. Tx [/quote]

It's not painful when injected, makes life so much easier!

RE: Maropitant in chronic rhinitis

Aine Seavers — Wed, 30 Jan 2019 23:04:17 GMT

Prevomax not available in Australia so I am not clear what your reply refers to.Are you saying you have used it in the nose ?or saying it is not painful like Cerenia?. Tx

Aine

RE: Maropitant in chronic rhinitis

Thomas Johnson — Wed, 30 Jan 2019 08:41:55 GMT

[quote user="Aine Seavers"]I however have yet to ever use Cerenia this way tho I do love Cerenia to use it in lots of other odds way. My concern is the injection liquid is painful sc so is it also painful via other routes??-and if not painful by being if kept cold-then cold medications in eyes and nose are of themselves more painful than if same medication applied at room temp/warm.. [/quote]

Just use Prevomax instead!

RE: Maropitant in chronic rhinitis

Aine Seavers — Wed, 30 Jan 2019 03:40:10 GMT

this is what I was advised:. " Injectable Cerenia(10mg/mL) added in a 1:10 ratio with plain saline nose-drops given daily does wonders.standard 15mL OTC saline drops - just add 1.5mL Cerenia. Lovely for shrinking down swollen tissues to help breathing!"

I however have yet to ever use Cerenia this way tho I do love Cerenia to use it in lots of other odds way. My concern is the injection liquid is painful sc so is it also painful via other routes??-and if not painful by being if kept cold-then cold medications in eyes and nose are of themselves more painful than if same medication applied at room temp/warm.. Would love to know more before I would use it this way. You can use Famvir for cats at lower doses as rate dependent pro-drug so small doses as good as large, acetylcysteine for n/l duct flushing effect and I have 'cured' some chronic rhinitis cats by happenstance when using Veraflox/pradofloxacin post c/s on another co-morbidity and the rhinitis there for years just 'went' away.

RE: Maropitant in chronic rhinitis

Robert FalconerTaylor — Tue, 29 Jan 2019 17:59:44 GMT

Take step back and look up - pitants nk1 - on google scholar

RE: Maropitant in chronic rhinitis

Kate Richardson — Tue, 29 Jan 2019 16:41:23 GMT

Maropitant has been reported as effective in allergic skin disease in cats amongst other things so it wouldn’t surprise me if it’s been used for chronic rhinitis as well! I’ll see if I can find out from my feline colleagues!

RE: Maropitant in chronic rhinitis

Thomas Johnson — Tue, 29 Jan 2019 16:01:38 GMT

[quote user="Anthony Dennison"]You can use the oral tablets for motion sickness. There is 2 doses on the data sheet for tablets IIRC.[/quote]

You do recall correctly, the data sheet says:

For prevention of vomiting induced by motion sickness in dogs aged 16 weeks of age or older

Cerenia tablets should be administered once daily, at a dose of 8 mg maropitant per kg bodyweight, using the numbers of tablets given in the table below. Tablets are breakable along the score line on the tablet.

Tablets should be administered at least one hour before starting the journey. The anti-emetic effect persists for at least 12 hours, which for convenience may allow administration the night before early morning travel. Treatment may be repeated for a maximum of two consecutive days.

In some individual dogs and when repeating the treatment, lower doses than recommended might be sufficient.

RE: Maropitant in chronic rhinitis

Anthony Dennison — Tue, 29 Jan 2019 14:02:36 GMT

[quote user="vetbl.locum"]

'The use of Cerenia solution for injection against vomiting due to motion sickness is not recommended.'

So is there a different dose?

[/quote]

You can use the oral tablets for motion sickness. There is 2 doses on the data sheet for tablets IIRC.

RE: Maropitant in chronic rhinitis

vetbl.locum — Tue, 29 Jan 2019 11:46:55 GMT

[quote user="Anthony Dennison"]

Not sure about rhinitis in cats, but there is a study in to it being used as a cough suppressant in canine chronic bronchitis at the travel sickness dose.

[/quote]

I am bit confused now , data sheet says:

'The use of Cerenia solution for injection against vomiting due to motion sickness is not recommended.'

So is there a different dose?

Rgds

RE: Maropitant in chronic rhinitis

Anthony Dennison — Tue, 29 Jan 2019 10:58:27 GMT

Not sure about rhinitis in cats, but there is a study in to it being used as a cough suppressant in canine chronic bronchitis at the travel sickness dose.

I presume it would work due to local inhibition of substance P, a pro-inflammatory mediator, but that's all I know.