Tamoxifen in canine mammary tumours

RE: Tamoxifen in canine mammary tumours

Anthony Dennison — Fri, 30 Nov 2018 16:48:26 GMT

The difficulty with mammary tumours is they're often complex mixed tumours so there is no single treatment solution to deal with the different cell types.

Using meloxicam for it's anti-VEGF properties is useful, possibly something like palladia to limit metastatic spread?

RE: Tamoxifen in canine mammary tumours

Robert FalconerTaylor — Fri, 23 Nov 2018 17:28:22 GMT

There's this from Small Animal Clinical Pharmacology Ed 2

RE: Tamoxifen in canine mammary tumours

Richard Carter — Fri, 23 Nov 2018 16:45:43 GMT

thanks - have read this one - particularly like the use of tarantulas... now where can I get some..

RE: Tamoxifen in canine mammary tumours

Beats — Fri, 23 Nov 2018 10:19:48 GMT

Haven't googled it yet, but...

my memory from pharmacology lectures back in the day was that tamoxifen acted as a ?partial estrogenic AGONIST in the bitch as opposed to ANTAGONIST.

Different receptor pharmacology from humans.

not sure if that helps as not sure what way round the logic in the suggested treatment is.

EDIT - search this from google on "tamoxifen" for relatively recent review

https://www.revmedvet.com/2016/RMV167_192_200.pdf