RE: miR-122 test for liver disease

Beats — Thu, 06 Sep 2018 07:17:04 GMT

[quote user="Emily Rainbow"]You forgot thyroid panel and ACTH stim to rule out other causes! :p[/quote]

That would have been an embarrassing omission prior to biopsy. Phew

RE: miR-122 test for liver disease

Emily Rainbow — Wed, 05 Sep 2018 21:18:35 GMT

You forgot thyroid panel and ACTH stim to rule out other causes! :p

RE: miR-122 test for liver disease

Beats — Wed, 05 Sep 2018 19:57:39 GMT

JVIM's gone open-access so can read even without library access.

https://onlinelibrary.wiley.com/doi/10.1111/jvim.15250

Thanks for flagging it up - will be interested to have a read.

I find some new tests (like new drugs) are useful and some are of little use and I historically have not been successful at predicting which are which from the limited information available at launch at launch, but it usually becomes apparent with time.

I'm assuming this is not commercially available yet?

[quote user="Martin Atkinson"]Is it just me or does anyone else find it difficult to understand how one test can possibly give a diagnosis of the pathology of liver disease. given the multiple possible causes, and add more to the diagnosis than a panel of ALP, ALT, Tbil, Cholesterol, BA and GGT?[/quote]

and TP, albumin, urea, glucose, AST, GLDH, CRP, SpecCPL, haematology with blood smear rbc morphological assessment, post-prandial BAs in addition to fasting, lepto-titres with MAT a week apart (and PCR on blood and urine of course, maybe even a serum antigen ELISA), ICH, full toxicology screen... am I missing anything else? Breath ammonia perhaps? (before proceeding to ultrasound scan, CT, MRI and biopsies with ever increasing tissue sampling sizes)

I undoubetdly underdiagnose, and therefore undertreat, liver disease.