4yr FN Cocker Spaniel with moderate/severe anaemia and mild azotaemia

RE: 4yr FN Cocker Spaniel with moderate/severe anaemia and mild azotaemia

Matt Hilary — Mon, 18 Jun 2018 15:52:19 GMT

Hypochromasia would support chronic blood loss so assuming repeatable I'd also be looking at the GI tract first, though if funds allow bone marrow biopsy would also be sensible.

Travelled to anywhere exotic?

RE: 4yr FN Cocker Spaniel with moderate/severe anaemia and mild azotaemia

Thomas Johnson — Mon, 18 Jun 2018 10:05:32 GMT

[quote user="Anthony Dennison"]

[quote user="David Mills"]

There is a form of IMHA that targets red cell precursors. Cockers are predisposed. Normally get a non regenerative anaemia.

Reach for the roids?

[/quote]

Interesting. Would you not get an inflammatory leukogram though? Not present in this case.

[/quote]

I saw a dog a couple of years ago that had immune-mediated destruction of red blood cell precursors. His PCV dropped from 26% to 21% over about 2 weeks, fibrinogen was elevated, but bloods were otherwise unremarkable, including normal white cell counts. I did bone marrow aspirates and biopsies and the diagnosis was made on those. He was treated with prednisolone and azathioprine, but also had a blood transfusion as his PCV dropped to 12%. He responded to treatment and did well for a couple of months, but as the doses were gradually dropped he started to become anaemic again, doses were increased and he improved, I also introduced cyclosporin, but then he started to become anaemic on the higher doses so was euthanased.

RE: 4yr FN Cocker Spaniel with moderate/severe anaemia and mild azotaemia

David Mills — Mon, 18 Jun 2018 09:57:16 GMT

[quote user="Anthony Dennison"]

[quote user="David Mills"]

There is a form of IMHA that targets red cell precursors. Cockers are predisposed. Normally get a non regenerative anaemia.

Reach for the roids?

[/quote]

Interesting. Would you not get an inflammatory leukogram though? Not present in this case.

[/quote]

Not always. I've only seen a couple, one did, one didn't. Need bone marrow biopsy to confirm.

Realistically, your treatment options for this are limited though, so I'd be trying this dog on some c/St.

RE: 4yr FN Cocker Spaniel with moderate/severe anaemia and mild azotaemia

Anthony Dennison — Mon, 18 Jun 2018 09:20:53 GMT

[quote user="David Mills"]

There is a form of IMHA that targets red cell precursors. Cockers are predisposed. Normally get a non regenerative anaemia.

Reach for the roids?

[/quote]

Interesting. Would you not get an inflammatory leukogram though? Not present in this case.

RE: 4yr FN Cocker Spaniel with moderate/severe anaemia and mild azotaemia

Gillian Mostyn — Sat, 16 Jun 2018 17:27:40 GMT

[quote user="Kate Richardson"]is erythropoietin measurable?[/quote]

Any pro cyclist will be able to answer that question...

RE: 4yr FN Cocker Spaniel with moderate/severe anaemia and mild azotaemia

Kate Richardson — Sat, 16 Jun 2018 16:17:35 GMT

is erythropoietin measurable? Might help determine if it’s kidneys or not. No idea if it’s even an available test!

RE: 4yr FN Cocker Spaniel with moderate/severe anaemia and mild azotaemia

David Mills — Sat, 16 Jun 2018 15:11:10 GMT

There is a form of IMHA that targets red cell precursors. Cockers are predisposed. Normally get a non regenerative anaemia.

Reach for the roids?

RE: 4yr FN Cocker Spaniel with moderate/severe anaemia and mild azotaemia

Joyce Whitehead — Sat, 16 Jun 2018 13:42:58 GMT

I’ve seen one dog with pure red cell aplasia, diagnosed on bone marrow biopsy, wbc and platelets remained normal throughout. With a spaniel I’m always looking for an autoimmune cause until riven otherwise. But I’d agree re guts, althiugh wouldn’t it be regenerating more?

RE: 4yr FN Cocker Spaniel with moderate/severe anaemia and mild azotaemia

Anthony Dennison — Sat, 16 Jun 2018 13:06:04 GMT

[quote user="vanessab"]

Had tCa returned to WNL? I would consider iCa as hyperCa could be related to lethargy - would be worth excluding?

[/quote]

Calcium normal now.

[quote user="robloxley"]How old dog?[/quote]

4 years old

[quote user="robloxley"] I'd be wanting to look at the guts further (scope, biopsy?) with the previous symptoms.[/quote]

That was my thinking too

RE: 4yr FN Cocker Spaniel with moderate/severe anaemia and mild azotaemia

Rob Loxley — Sat, 16 Jun 2018 13:01:51 GMT

How old dog? Always worry with hypercalcemia for neoplasia esp lymphoma; Maybe worth chasing the calcium if still high. I'd be wanting to look at the guts further (scope, biopsy?) with the previous symptoms. Is it microcytic? Azotaemia could be secondary to hypercalcemia. What's tCa and iCa doing?

RE: 4yr FN Cocker Spaniel with moderate/severe anaemia and mild azotaemia

vanessab — Sat, 16 Jun 2018 12:50:50 GMT

Had tCa returned to WNL? I would consider iCa as hyperCa could be related to lethargy - would be worth excluding?

RE: 4yr FN Cocker Spaniel with moderate/severe anaemia and mild azotaemia

Linda Filshie — Sat, 16 Jun 2018 11:13:54 GMT

Could check for faecal occult blood but they need to be on a red meat free diet for a few days before. If you're sedating/GAing for BM biospy I'd do survey chest and abd rads as well.