Perianal adenoma and tardak

RE: Perianal adenoma and tardak

Tim Browning — Mon, 23 Apr 2018 10:54:12 GMT

I have used Ypozane a lot for old dogs that are a bit of a risk and it seems to work as well as castration. Only need a weeks treatment every 6 months.

RE: Perianal adenoma and tardak

KathW — Fri, 20 Apr 2018 22:38:16 GMT

I have used Ypozane in the past - after discussing it with the drug company

Worked well on that single case that wasn’t a candidate for surgery.

Would be worth a chat with Virbac.

RE: Perianal adenoma and tardak

Thomas Johnson — Fri, 20 Apr 2018 15:53:48 GMT

[quote user="villagevet"]I would definitely try suprelorin - where GA for castration is not safe or consent not given, suprelorin can mimic effect of castration and cause these to regress, if kept up 16-12months then it should stay away. I have a few old dogs on this regimen for the last 12-18months and lesions are completely resolved (still palpable in one but not ulcerated, absent in others).[/quote]

I have also had perianal adenomas shrink significantly after placing a Suprelorin implant, the last dog I used one in was euthanased for other reasons 3 months later, but the perianal adenoma had virtually disappeared.

RE: Perianal adenoma and tardak

Lindsey Edwards — Fri, 20 Apr 2018 13:56:37 GMT

I would definitely try suprelorin - where GA for castration is not safe or consent not given, suprelorin can mimic effect of castration and cause these to regress, if kept up 16-12months then it should stay away. I have a few old dogs on this regimen for the last 12-18months and lesions are completely resolved (still palpable in one but not ulcerated, absent in others).

Yes there is a recurrent cost and owners should be advised of such - most of the ones I have discussed with owners were happy to try for the first 6months, viewing it as six months they wouldn't have otherwise and are very hapy to maintain course as is thereafter when otherwise healthy. Should caution owners of risk that mass could be neoplastic in which case will not respond I have not had an entire male fail to respond (always check carefully to rule out anal gland carcinoma first though!)

RE: Perianal adenoma and tardak

janine redman — Fri, 20 Apr 2018 13:23:32 GMT

Thanks for your input , just checked records.

Dog is a grumpy 14 yo entire male collie cross and seems perianal masses first noticed in 2014 and o declined surgery at that time . They are now multiple ulcerated infected and a challenging and expensive surgical option in an elderly dog. I appreciate your help. Not sure I can persuade them to opt for surgery and euthanasia is the other option .

RE: Perianal adenoma and tardak

janine redman — Fri, 20 Apr 2018 10:19:09 GMT

Thanks for your input , just checked records.

RE: Perianal adenoma and tardak

Chris Geddes — Fri, 20 Apr 2018 09:44:51 GMT

I seem to remember that Ypozane is sometimes successful. I know it doesn't make sense considering the pharmacodynamics of how it works for BPH, but I'm pretty sure it does work. Cheap and easy - one tablet a day for a week. Speak to Virbac?

RE: Perianal adenoma and tardak

Clive Ansell — Fri, 20 Apr 2018 08:28:17 GMT

+1 for castration being the treatment of choice, unless a very good reason not too. Often find that anal adenoma regress after castration and don't usually touch them.

I've used Tardak which seems to work initially, but becomes less effective over time. Plus it is expensive of course.

Never tried Suprelorin.

RE: Perianal adenoma and tardak

David Mills — Fri, 20 Apr 2018 01:11:48 GMT

[quote user="Braden Collins"]

If they're perianal hyperplasia they should respond to either. If they're true adenomas they're unlikely to resolve fully with either. Worth a try though. I'd probably start with tardak and see what happens.

[/quote]

Confused by this. According to literature 95% of anal adenomas resolve with cessation of testosterone i.e. Castration. But maybe you meant either medical tx?

Hyperplasia is an asymptomatic condition mostly, not sure if I've ever seen it?!

RE: Perianal adenoma and tardak

Braden Collins — Fri, 20 Apr 2018 00:05:47 GMT

RE: Perianal adenoma and tardak

David Mills — Thu, 19 Apr 2018 23:36:51 GMT

Castration and debulking with cautery if appropriate.

If the dog can't withstand a 30 minute GA will be dead soon anyway. I hate medical treatment of these, and the price of tardak and suprelorin is astronomical in the long run.

RE: Perianal adenoma and tardak

Rob Loxley — Thu, 19 Apr 2018 21:59:11 GMT

[quote user="janine redman"]wondered if anyone had had success with either tardak or suprelorin in cases like this to slow further growth[/quote]

Used suprelorin in a creaky 17yo dog for similar and seemed helpful

RE: Perianal adenoma and tardak

Niall Taylor — Thu, 19 Apr 2018 21:11:53 GMT

I'm sure suprelorin would help but you'd get better reults if you debulked them first, preferably after giving a course of antibiotics vs secondary infection.

Niall

RE: Perianal adenoma and tardak

Joyce Whitehead — Thu, 19 Apr 2018 20:42:45 GMT

I’ve got a similar, elderly, creaky entire lab. Some response to tardak, and much better to suprelorin. One ulcerated one was still infected and horrible so I removed it two weeks ago, now have a much happier patient!