AT 10 alternative

RE: AT 10 alternative

Andrew Kent — Fri, 15 Jun 2018 17:03:08 GMT

[quote user="Phil Tricklebank"]Hi Andrew, I have a cat on 25ug of AT10 BID. Have you found to need to use a similar ug dose of alfacalcidiol (One-Alpha), compared to dihydrotachysterol, or a much lower dose? 25ug of One-Alpha would be 25 capsules, which seems very high.[/quote]

Hi Phil,

The dosing is very different so don't give 25 capsules!

Alfacalcidol is dosed similar to calcitriol starting at around 15 nanogram/kg BID although it is a bit less effective than calcitriol so often we need to titrate up over time.

Andy

RE: AT 10 alternative

Phil Tricklebank — Fri, 15 Jun 2018 16:23:38 GMT

Hi Andrew, I have a cat on 25ug of AT10 BID. Have you found to need to use a similar ug dose of alfacalcidiol (One-Alpha), compared to dihydrotachysterol, or a much lower dose? 25ug of One-Alpha would be 25 capsules, which seems very high.

RE: AT 10 alternative

Beats — Tue, 03 Apr 2018 20:25:38 GMT

http://www.lloydspharmacy.com/en/dihydrotachysterol-250micrograms-ml-oral-solution-sugar-free

suggest that may be available in UK, but may not be or may be for human use only.

could import from EU perhaps under an STC like get sucralfate etc?

German approved brand ATITEN Lösung for instance?

https://www.medpex.de/atiten-loesung-p643979

https://www.bodfeld-apotheke.de/search/result?term=atiten&row=0&order_by=Relevance&order_direction=DESC

Same "Atiten" brand approved by Italian medicines regulator (https://farmaci.agenziafarmaco.gov.it/bancadatifarmaci/farmaco?farmaco=005713)

and marketed by Teofarma (no guarantee you can get it of course, but appears to be avialable: https://www.starbene.it/farmaci/atiten-os-gtt-15ml-1mg_ml_005713019)

A11CC02 is the ATC code for dihydrotachysterol if searching outside the UK for a suitable product. (https://www.whocc.no/atc_ddd_index/?code=A11CC02)

The Canadians hint at having a product also: http://napra.ca/nds/dihydrotachysterol

0.2mg tablets crop up a lot on google also if these are suitable, e.g. http://www.bbfarma.com/atc-code/A11CC02-EN-DIHYDROTACHYSTEROL.html

PS - there are also clear cons out there, e.g. I can guarantee that Abbott does not make tachyrol tablets licensed in Ireland!!! https://myhealthbox.eu/en/medicine/tachyrol/808350

RE: AT 10 alternative

Rob Davis — Tue, 03 Apr 2018 19:03:58 GMT

RE: AT 10 alternative

Andrew Kent — Tue, 03 Apr 2018 18:54:17 GMT

Unfortunately converting is always problematic and I think you have to expect probable destabilisation. Otherwise we end up going through a similar process of titrating the dose to effect.

Andy

RE: AT 10 alternative

Rob Davis — Tue, 03 Apr 2018 15:20:50 GMT

Thanks for that, Andy. Do you have any advice for converting. The case in question has been a bit of a nightmare to stabilise and I am really not looking forward to telling the owner we've got to start again.....

RE: AT 10 alternative

Andrew Kent — Tue, 03 Apr 2018 15:00:18 GMT

Hi Rob,

No direct equivalent that I am aware of. We are using alfacalcidol (one-alpha) now.

Andy